Rapamycin Frequently Asked Questions (FAQ)

[RapAdmin]

Rapamycin: The Gold Standard of Life Extension Drugs

Rapamycin is, by far, the world’s leading candidate for an effective and accessible longevity (anti-aging) drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of people already using it to improve their lives. At a minimum, you probably want to learn as much as you can about it and keep a close eye on the research going forward.

Rapamycin is considered by many geroscience researchers to be the “gold standard” of longevity drugs; the healthy lifespan improvement seen in animal trials are consistently the best of any drug (typically 15% to 30% lifespan improvement). It increases healthspan and lifespan in every organism its been tested in; from yeast, to flies, to worms, to mice (over a billion years of evolution). It has the most reproducible life extension effect, having been tested and retested by many different labs around the world in a wide variety of different species of organisms and animals. Over 29 rapamycin lifespan mice studies have been completed with positive results. Rapamycin also seems to slow, or reverse, aging in many different organs. And, rapamycin is an FDA -approved drug that has been in use for over 20 years, by hundreds of thousands of people (in cancer and organ transplant treatment regimens) and its now classified as a generic drug, so it is inexpensive to buy.

BUT, rapamycin is also a serious drug that can have serious side effects, depending on how its dosed and other factors. This is not a risk-free drug (no drugs are). If you are considering using rapamycin be SURE to spend a few months to read the literature here, and watch the videos, so you can make an informed decision, ideally working in concert with a doctor. There can be negative side effects (typically dose-dependent) like increases in lipid levels or blood glucose levels, so most of us do regular blood testing to check for these issues, and make adjustments based on test results Don’t just rush into taking rapamycin because you heard a podcast mention it. Take your time, read as much as you can of the information below, and follow the discussions in our forum.

Rapamycin Basics

• Why Take Rapamycin for Anti-Aging?

• The Case for Starting Rapamycin Earlier in Life (e.g. late 20s) vs middle age (e.g. 50+)

• What are the Anti-aging Benefits of Rapamycin? - Personal Experiences

• The Side Effects of Rapamycin - What are People Experiencing?

• How Does Rapamycin Make You Feel?

• The Rapamycin Dose for Anti-Aging?

• Rapamycin Dose Cycling (Time Off Drug) - what is Right?

• Evaluation of Off-label Rapamycin use to Promote Healthspan in 333 Adults - new Paper

• Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs

• How to Get / Buy Rapamycin, How to get a Prescription

• Implementing Rapamycin: Approaches, Considerations, Muscle Growth & Longevity | Dr Richard Cohen ( A Video Series)

• Rapamycin may Slow Skin Aging

• Rapamycin for Hair Growth / Pigmentation

• Reverse Gray Hair , Hair Repigmentation

• How to Reverse Skin Aging

• Women Taking Rapamycin to Maintain Fertility / Prevent Menopause?

• Approximately 87% of Rapamycin Users Plan to Keep Using the Longevity Drug

• Can you Share Your Longevity / Healthspan Drug / Supplement Regimen

• Is rapamycin an effective longevity drug? (Attia)

Learn More about Rapamycin

• The Best Videos to Learn More about Rapamycin?

• More Good Educational Videos on Rapamycin

• Video - Why Rapamycin is the Gold Standard of Longevity Drugs (3/2022, M. Kaeberlein)

• The Best Podcasts on Healthy Longevity and Geroscience

• Who in the Health and Longevity Field is Taking Rapamycin, Who isn’t, and Why?

• Eric Verdin, CEO of the leading biology of aging research center (The Buck Institute) takes Rapamycin

• "Rapamycin is a no-brainer” says Vinod Khosla, Leading Longevity Biotech Venture Capitalist

• All the Mouse Studies (over 45 studies) Showing Rapamycin Lifespan Extension

• Good Biology of Aging / Rapamycin Educational Resources

• Active and Ongoing Clinical Trials with Rapamycin

Benefits of Rapamycin

• Impressive Biological Age Reductions with Rapamycin (anecdotal)

• The Psychological Benefits of Rapamycin, Rapamycin Changes How You Think About Aging

• The Anti-Aging Benefits of Rapamycin - What the Research Says

• Rapamycin Slows Aging, or Reverses Aging, in Many Organs

• Potential for 30 Extra Years of Healthy Lifespan with Rapamycin

• Rapamycin Prevents Blood Stem Cell Aging

• Rapamycin for Cancer Prevention

• Rapamycin and Visceral Fat Reduction

• Rapamycin for Female Fertility Maintenance During Aging

• Rapamycin and the Issue of Getting Through the Blood Brain Barrier

• Rapamycin Improves Erections

• Rapamycin delays age-related osteoarthritis

• Rapamycin & Everolimus Use Is Associated With a Favorable Outcome of COVID-19

• 70 is the new 30? Inspiring Stories of Healthy Longevity

Side Effects of Rapamycin

• How Safe is Rapamycin? Some Key Data Points

• Rapamycin Risks for Healthy Humans - What the Animal Research Suggests

• How Long Have People Been taking Rapamycin for Anti-aging?

• What are the Rapamycin Clinical Studies that Have Been Done in Healthy Humans? (vs. organ transplant patients, cancer patients, etc.)

• Why do people have concerns regarding side effects in humans? Why we are not running thousands of human trials with rapamycin already?

• Rapamycin and Cardiovascular Disease

Tracking Your Biomarkers and Results

• A Friendly Biological Age Reduction Competition?

• What are your top 10 biomarkers to track for improving healthspan and longevity?

People Write About Their Experiences with Rapamycin

• My DOG, My PARTNER, and ME: A Week by Week Rapalogue

• Krister Kaupi - My Rapamycin Journey Notes

• My Rapamycin Journey log

• Yet another rapalog (37 M)

• Starting rapamycin next month - 27 years old

• New users starting up on Rapamycin!

• Experiences starting Rapamycin for first time

Rapamycin, etc. for Aging Skin and Hair, Oral Health

• Rapamycin May Slow Skin Aging (Drexel University Study)

• DIY Rapamycin Skin Cream

• Where to buy Rapamycin Skin Cream

• Rapamycin - skin cancer

• Senolytics Topically Administered to Skin for Antiaging Effects

• Skin/beauty/longevity treatments in Seoul Korea (warning: disgusting pictures of my face)

• The unexpected ways your skin impacts your health and longevity (NewScientist)

• Bryan Johnson's Anti-aging Skincare Routine

• IL-17 Protein Plays an Important Role in Skin Aging, FDA Approved Therapies Available

• Reversing Skin Aging at the Cellular Level (Carolina Reis Oliveira and Alessandra Zonari, OneSkin)

• Skin Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

• The curious ways your skin shapes your health (BBC)

• Rapamycin for Hair Growth and Pigmentation, Skin Anti-aging

• Reverse Gray Hair, Hair Repigmentation

• Grey Hair turning Black again after 10 years

• Rapamycin Toothpaste? New Study Funded: Towards reversing periodontal disease using Rapamycin

• DIY Rapamycin Toothpaste & Flossing Paste

Rapamycin and Exercise / Muscle Growth

• Endurance Athletes Using Rapamycin?

• Rapamycin, mTORC1 and Exercise - Observations and Research

• Rapamycin and Exercise: Is There any Muscle Growth Inhibition?

• Rapamycin Personal Results: Lab Tests, Exercise and Muscle Growth

Surveys & Polls of Rapamycin Users

• Poll: How do you get your Rapamycin: Doctor Prescription, or Just Buy It?

• Poll: Would You Participate in a Higher Rapamycin Dose Clinical Trial?

• Poll: How Many Years Until Rapamycin Goes Mainstream?

• Rapamycin User Poll / Survey: Dosing Frequency, Dose Level, Benefits, Side effects, etc.

• Rapamycin User Survey #2: How Long Taken Rapamycin, How Old When Started, Timing of Benefits and Side Effects, Other Longevity Drugs and Supplements, etc.

How to Use / Dose Rapamycin in Anti-aging Applications

• How to Increase the Bioavailability, and Save Money, on Rapamycin?

• How and Where to Get a Blood Test to Check Rapamycin (sirolimus) Levels

• What are all the Different Medical / Product Names for Rapamycin?

How to get Rapamycin Prescription, How to Buy Rapamycin

• Doctors who prescribe rapamycin for Anti-aging - A Full List (USA, Mexico, Europe…)

• Where to Buy Rapamycin (Sirolimus), What is the Cost?

• How are People Importing Rapamycin to Save Money?

• Buy Rapamycin Online - List of Reliable Online Pharmacies for Buying Rapamycin

• Rapamycin / Sirolimus from India, Example Lab Test Report on Quality / Purity

• Why and How to Test Your Rapamycin for Purity, Dosage and Contaminants?

• Rapamycin / Sirolimus Powder from China - Example 3rd party Lab Analysis

Why Consider Everolimus instead of Rapamycin (Sirolimus)

• You can use Everolimus instead of Sirolimus / Rapamycin

• Rapamycin and Everolimus and the Issue of Getting Through the Blood Brain Barrier

• Side Effect Profile for Everolimus: Doses from 10mg to 70mg per Week

Rapamycin for Dogs, Cats, Horses

• Rapamycin for Dogs and other Pets - Dosing Details and more?
• Rapamycin for Cats (getting them to eat it)
• Rapamycin for Horses

Other Top Longevity Drugs:

• Rapamycin Plus Acarbose, up to 34% Lifespan Increase

• Canagliflozin - Another Top Anti-aging Drug

• Canagliflozin - One and Four-month Personal Use Updates

• Acarbose - Another Top Anti-Aging Drug

• 17 - Alpha Estradiol - Another Top Anti-Aging Drug

• Captopril: Another anti-aging drug, 4 to 5 % Lifespan Increase in Females

• Cocktail of Rapamycin, Acarbose and Phenylbutyrate Slows Aging in Mice

• ISRIB - Another Potential Anti-Aging Brain-focused Drug in Testing

• The most promising Longevity Drugs

• Meclizine (mTOR inhibitor), and GLYLO (supplement combination)

• Gemfibrozil, a lipid-lowering drug, improves damage in a mouse model of aging

IGF-1 Lowering Drugs for Longevity

• Age1 Venture Capital Launches New Youtube Channel on Longevity & Biotech

• Could a rare mutation that causes dwarfism also slow ageing? (Nature)

• IGF-1 is Lower for Centenarians

• Another (likely) Longevity Drug - Somavert / Pegvisomant

• A Life-Extension Drug for Big Dogs Is Getting Closer to Reality (Wired)

• The Longevity Summit, News & Update - #9 by RapAdmin

• High IGF1 level

Anti-Aging Supplements:

• Astaxanthin (Preliminary NIA ITP results suggest a 12% median lifespan improvement in mice)
• Glycine and Gly/NAC
• Protandim, a mixture of botanical extracts that activate Nrf2, extended median lifespan in males only. (7% median lifespan increase)

Other Longevity Strategies (treatments):

• Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area

• Lowering the Cost / Improving Access for Therapeutic Plasma Exchange (Plasmapheresis)

• Irina Conboy Plasmapheresis Webinar

• Harold Katcher (the plasmapheresis person) is the most inspiring late bloomer ever

• Plasma Dilution appears to rejuvenate humans

• Plasma Exchange, GDF11 or Klotho: Which Would You Do?

• Anti-Aging Benefits Could Be Found in Blood (Discover)

• Plasma Dilution - My Experience

• Old plasma dilution reduces human biological age

• Does plasma donation or blood donation also lead to “plasma dilution”?

• Systemic induction of senescence in young mice after single heterochronic blood exchange

• Tony Wyss-Coray | Young Blood for Old Brain

• Young Blood for Old Brains and the Quest to Slow Brain Aging & Rate of Aging

Longevity Clinics

Longevity clinics are health optimization and preventative medicine focused healthcare centers that provide health evaluations and early risk identification of potential disease processes. We believe that this preventative focus is the future of healthcare (compared to the “sick care” of today where they wait until you get sick before they do much of anything), but right now the full services are only available to people who want to spend $5,000 to $100,000 per year. Following are some details on perhaps the leading longevity centers in the world today, and the services they offer.

• The Longevity Clinic Will See You Now—for $100,000 (WSJ)
• The quest to legitimize longevity medicine (MIT)
• Longevity Clinics: What They Are, Services & More
  Examples of Longevity Clinics (Detailed Presentations on each)
• Longevity Clinics: Dr. Andrea Maier, Chi Longevity, Singapore
• Longevity Clinics: Fountain Life, Mona Ezzat – Velinov, MD
• Longevity Clinics: Cleveland Clinic, Wellness and Preventive Medicine, Michael F. Roizen MD
• Longevity Clinics: Human Longevity Inc., Dr. David Karrow
• Longevity Clinics: Dr. Mark Hyman, Function Health (Functional Health seems to focus on health testing, starting at $400 or so for a suite of tests).

The History of Rapamycin

• The Discovery of Rapamycin - The expedition to Easter Island and the first paper that started it all (1975)