Rapamycin Frequently Asked Questions (FAQ)

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Rapamycin: The Gold Standard of Life Extension Drugs

Rapamycin is, by far, the world’s leading candidate for an effective and accessible anti-aging drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of people already using it to improve their lives. At a minimum, you probably want to learn as much as you can about it and keep a close eye on the research going forward.

Rapamycin is considered by many geroscience researchers to be the “gold standard” of anti-aging drugs; the lifespan improvement seen in animal trials are consistently the best of any drug (approximately 15% to 30%). It increases healthspan and lifespan in every organism its been tested in; from yeast, to flies, to worms, to mice (over a billion years of evolution). It has the most reproducible life extension effect, having been tested and retested by many different labs around the world in a wide variety of different species of organisms and animals. Rapamycin also seems to slow, or reverse, aging in many different organs. And, rapamycin is an FDA -approved drug that has been in use for over 20 years, by hundreds of thousands of people (in cancer and organ transplant treatment regimens) and its now classified as a generic drug, so is inexpensive to buy.

BUT, rapamycin is also a serious drug that can have serious side effects, depending on how its dosed and other factors. This is not a risk-free drug (no drugs are). If you are considering using rapamycin be SURE to spend a few months to read the literature, and watch the videos, so you can make an informed decision, ideally working in concert with a doctor. Don’t just rush into taking rapamycin because you heard a podcast mention it. Take your time, read all the information below, and follow the discussions in the forum for a few months.

Rapamycin Basics

• Why Take Rapamycin for Anti-Aging?

• The Case for Starting Rapamycin Earlier in Life (e.g. late 20s) vs middle age (e.g. 50+)

• What are the Anti-aging Benefits of Rapamycin? - Personal Experiences

• The Side Effects of Rapamycin - What are People Experiencing?

• How Does Rapamycin Make You Feel?

• What is the Rapamycin Dosing / Dose for Anti-Aging?

• Evaluation of Off-label Rapamycin use to Promote Healthspan in 333 Adults - new Paper

• Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs

• How to Get / Buy Rapamycin, How to get a Prescription

• Rapamycin may Slow Skin Aging

• Rapamycin for Hair Growth / Pigmentation

• Reverse Gray Hair , Hair Repigmentation

• How to Reverse Skin Aging

• Women Taking Rapamycin to Maintain Fertility / Prevent Menopause?

• Approximately 87% of Rapamycin Users Plan to Keep Using the Longevity Drug

• Can you Share Your Longevity / Healthspan Drug / Supplement Regimen

Learn More about Rapamycin

• The Best Videos to Learn More about Rapamycin?

• More Good Educational Videos on Rapamycin

• Video - Why Rapamycin is the Gold Standard of Longevity Drugs (3/2022, M. Kaeberlein)

• The Best Podcasts on Healthy Longevity and Geroscience

• Who in the Health and Longevity Field is Taking Rapamycin, Who isn’t, and Why?

• "Rapamycin is a no-brainer” says Vinod Khosla, Leading Longevity Biotech Venture Capitalist

• All the Mouse Studies (over 45 studies) Showing Rapamycin Lifespan Extension

• Good Biology of Aging / Rapamycin Educational Resources

Benefits of Rapamycin

• Impressive Biological Age Reductions with Rapamycin (anecdotal)

• The Psychological Benefits of Rapamycin, Rapamycin Changes How You Think About Aging

• The Anti-Aging Benefits of Rapamycin - What the Research Says

• Rapamycin Slows Aging, or Reverses Aging, in Many Organs

• Potential for 30 Extra Years of Healthy Lifespan with Rapamycin

• Rapamycin Prevents Blood Stem Cell Aging

• Rapamycin for Cancer Prevention

• Rapamycin and Visceral Fat Reduction

• Rapamycin for Female Fertility Maintenance During Aging

• Rapamycin and the Issue of Getting Through the Blood Brain Barrier

• Rapamycin Improves Erections

• Rapamycin delays age-related osteoarthritis

• Rapamycin & Everolimus Use Is Associated With a Favorable Outcome of COVID-19

Side Effects of Rapamycin

• How Safe is Rapamycin? Some Key Data Points

• Rapamycin Risks for Healthy Humans - What the Animal Research Suggests

• How Long Have People Been taking Rapamycin for Anti-aging?

• What are the Rapamycin Clinical Studies that Have Been Done in Healthy Humans? (vs. organ transplant patients, cancer patients, etc.)

• Why do people have concerns regarding side effects in humans? Why we are not running thousands of human trials with rapamycin already?

• Rapamycin and Cardiovascular Disease

Rapamycin for Skin and Hair, Oral Health

• Rapamycin May Slow Skin Aging (Drexel University Study)

• DIY Rapamycin Skin Cream

• Rapamycin for Hair Growth and Pigmentation, Skin Anti-aging

• Reverse Gray Hair, Hair Repigmentation

• Rapamycin Toothpaste? New Study Funded: Towards reversing periodontal disease using Rapamycin

• DIY Rapamycin Toothpaste & Flossing Paste

Rapamycin and Exercise / Muscle Growth

• Rapamycin, mTORC1 and Exercise - Observations and Research

• Rapamycin and Exercise: Is There any Muscle Growth Inhibition?

• Rapamycin Personal Results: Lab Tests, Exercise and Muscle Growth

Surveys & Polls of Rapamycin Users

• Poll: How do you get your Rapamycin: Doctor Prescription, or Just Buy It?

• Poll: Would You Participate in a Higher Rapamycin Dose Clinical Trial?

• Poll: How Many Years Until Rapamycin Goes Mainstream?

• Rapamycin User Poll / Survey: Dosing Frequency, Dose Level, Benefits, Side effects, etc.

• Rapamycin User Survey #2: How Long Taken Rapamycin, How Old When Started, Timing of Benefits and Side Effects, Other Longevity Drugs and Supplements, etc.

How to Use / Dose Rapamycin in Anti-aging Applications

• How to Increase the Bioavailability, and Save Money, on Rapamycin?

• How and Where to Get a Blood Test to Check Rapamycin (sirolimus) Levels

• What are all the Different Medical / Product Names for Rapamycin?

How to get Rapamycin Prescription, How to Buy Rapamycin

• Doctors who prescribe rapamycin for Anti-aging - A Full List (USA, Mexico, Europe…)

• Where to Buy Rapamycin (Sirolimus), What is the Cost?

• How are People Importing Rapamycin to Save Money?

• Buy Rapamycin Online - List of Reliable Online Pharmacies for Buying Rapamycin

• Rapamycin / Sirolimus from India, Example Lab Test Report on Quality / Purity

• Why and How to Test Your Rapamycin for Purity, Dosage and Contaminants?

• Rapamycin / Sirolimus Powder from China - Example 3rd party Lab Analysis

Why Consider Everolimus instead of Rapamycin (Sirolimus)

• You can use Everolimus instead of Sirolimus / Rapamycin

• Rapamycin and Everolimus and the Issue of Getting Through the Blood Brain Barrier

• Side Effect Profile for Everolimus: Doses from 10mg to 70mg per Week

Rapamycin for Dogs

• Rapamycin for Dogs and other Pets - Dosing Details and more?
• Rapamycin for Cats (getting them to eat it)

Other Top Anti-Aging Drugs:

• Rapamycin Plus Acarbose, up to 34% Lifespan Increase

• Canagliflozin - Another Top Anti-aging Drug

• Canagliflozin - One and Four-month Personal Use Updates

• Acarbose - Another Top Anti-Aging Drug

• 17 - Alpha Estradiol - Another Top Anti-Aging Drug

• Captopril: Another anti-aging drug, 4 to 5 % Lifespan Increase in Females

• Cocktail of Rapamycin, Acarbose and Phenylbutyrate Slows Aging in Mice

• ISRIB - Another Potential Anti-Aging Brain-focused Drug in Testing

• The most promising Longevity Drugs

• Meclizine (mTOR inhibitor), and GLYLO (supplement combination)

• Gemfibrozil, a lipid-lowering drug, improves damage in a mouse model of aging

Anti-Aging Supplements:

• Astaxanthin (Preliminary NIA ITP results suggest a 12% median lifespan improvement in mice)
• Glycine and Gly/NAC
• Protandim, a mixture of botanical extracts that activate Nrf2, extended median lifespan in males only. (7% median lifespan increase)

The History of Rapamycin

• The Discovery of Rapamycin - The expedition to Easter Island and the first paper that started it all (1975)