Rapamycin: The Gold Standard of Life Extension Drugs
Rapamycin is, by far, the world’s leading candidate for an effective and accessible longevity (anti-aging) drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of people already using it to improve their lives. We estimate about 20,000 people are taking rapamycin for longevity purposes today, as of Sept. 2024, and increasing quickly, at about 300% per year. At a minimum, you probably want to learn as much as you can about it and keep a close eye on the research going forward.
Rapamycin is considered by many geroscience researchers to be the “gold standard” of longevity drugs; the healthy lifespan improvement seen in animal trials are consistently the best of any drug (typically 15% to 30% lifespan improvement). It increases healthspan and lifespan in every organism its been tested in; from yeast, to flies, to worms, to fish, to mice, to rats, and now monkeys (over a billion years of evolution). It has the most reproducible life extension effect, having been tested and retested by many different labs around the world in a wide variety of different species of organisms and animals. Over 29 rapamycin lifespan mice studies have been completed with positive results. Rapamycin also seems to slow, or reverse, aging in many different organs. And, rapamycin is an FDA -approved drug that has been in use for over 20 years, by hundreds of thousands of people (in cancer and organ transplant treatment regimens) and its now classified as a generic drug, so it is inexpensive to buy.
BUT, rapamycin is also a serious drug that can have serious side effects, depending on how its dosed and other factors. This is not a risk-free drug (no drugs are). If you are considering using rapamycin be SURE to spend a few months to read the literature here, and watch the videos, so you can make an informed decision, ideally working in concert with a doctor. There can be negative side effects (typically dose-dependent) like increases in lipid levels or blood glucose levels, so many people do periodic (every 3 months or so) blood testing to check for these potential issues, and make adjustments based on test results Don’t just rush into taking rapamycin because you heard a podcast mention it. Take your time, read as much as you can of the information below, and follow the discussions in our forum.
Rapamycin Basics
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The Case for Starting Rapamycin Earlier in Life (e.g. late 20s) vs middle age (e.g. 50+)
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What are the Anti-aging Benefits of Rapamycin? - Personal Experiences
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The Side Effects of Rapamycin - What are People Experiencing?
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Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial Results
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Evaluation of Off-label Rapamycin use to Promote Healthspan in 333 Adults - new Paper
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Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs
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Implementing Rapamycin: Approaches, Considerations, Muscle Growth & Longevity | Dr Richard Cohen ( A Video Series)
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Women Taking Rapamycin to Maintain Fertility / Prevent Menopause?
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Approximately 87% of Rapamycin Users Plan to Keep Using the Longevity Drug
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Can you Share Your Longevity / Healthspan Drug / Supplement Regimen
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There are likely about 18,000+ Rapamycin Users in the USA Now
Learn More about Rapamycin
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Video - Why Rapamycin is the Gold Standard of Longevity Drugs (3/2022, M. Kaeberlein)
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Who in the Health and Longevity Field is Taking Rapamycin, Who isn’t, and Why?
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"Rapamycin is a no-brainer” says Vinod Khosla, Leading Longevity Biotech Venture Capitalist
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All the Mouse Studies (over 45 studies) Showing Rapamycin Lifespan Extension
Benefits of Rapamycin
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Impressive Biological Age Reductions with Rapamycin (anecdotal)
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The Psychological Benefits of Rapamycin, Rapamycin Changes How You Think About Aging
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Feeling younger than your age may be good for your health (WaPo)
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The Anti-Aging Benefits of Rapamycin - What the Research Says
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Potential for 30 Extra Years of Healthy Lifespan with Rapamycin
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Rapamycin and the Issue of Getting Through the Blood Brain Barrier
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Rapamycin & Everolimus Use Is Associated With a Favorable Outcome of COVID-19
Side Effects of Rapamycin
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Rapamycin Risks for Healthy Humans - What the Animal Research Suggests
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Cautionary Tales in Longevity Medicine (Longevity Clinic Roundtable)
Tracking Your Biomarkers and Results
People Write About Their Experiences with Rapamycin
Rapamycin, etc. for Aging Skin and Hair, Oral Health
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Senolytics Topically Administered to Skin for Antiaging Effects
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Skin/beauty/longevity treatments in Seoul Korea (warning: disgusting pictures of my face)
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The unexpected ways your skin impacts your health and longevity (NewScientist)
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IL-17 Protein Plays an Important Role in Skin Aging, FDA Approved Therapies Available
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Reversing Skin Aging at the Cellular Level (Carolina Reis Oliveira and Alessandra Zonari, OneSkin)
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Skin Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience
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Rapamycin Toothpaste? New Study Funded: Towards reversing periodontal disease using Rapamycin
Rapamycin and Exercise / Muscle Growth
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Rapamycin and Exercise: Is There any Muscle Growth Inhibition?
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Rapamycin Personal Results: Lab Tests, Exercise and Muscle Growth
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Bodybuilding and Rapamycin in conjunction with non-hormonal and non-steroid supplements
Surveys & Polls of Rapamycin Users
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Poll: How do you get your Rapamycin: Doctor Prescription, or Just Buy It?
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Poll: Would You Participate in a Higher Rapamycin Dose Clinical Trial?
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Rapamycin User Poll / Survey: Dosing Frequency, Dose Level, Benefits, Side effects, etc.
How to Use / Dose Rapamycin in Anti-aging Applications
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How to Increase the Bioavailability, and Save Money, on Rapamycin?
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How and Where to Get a Blood Test to Check Rapamycin (sirolimus) Levels
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What are all the Different Medical / Product Names for Rapamycin?
How to get Rapamycin Prescription, How to Buy Rapamycin
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Doctors who prescribe rapamycin for Anti-aging - A Full List (USA, Mexico, Europe…)
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Buy Rapamycin Online - List of Reliable Online Pharmacies for Buying Rapamycin
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Rapamycin / Sirolimus from India, Example Lab Test Report on Quality / Purity
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Why and How to Test Your Rapamycin for Purity, Dosage and Contaminants?
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Rapamycin / Sirolimus Powder from China - Example 3rd party Lab Analysis
Why Consider Everolimus instead of Rapamycin (Sirolimus)
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Rapamycin and Everolimus and the Issue of Getting Through the Blood Brain Barrier
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Side Effect Profile for Everolimus: Doses from 10mg to 70mg per Week
Rapamycin for Dogs, Cats, Horses
- Rapamycin for Dogs and other Pets - Dosing Details and more?
- Rapamycin for Cats (getting them to eat it)
- Rapamycin for Horses
Other Top Longevity Drugs:
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Captopril: Another anti-aging drug, 4 to 5 % Lifespan Increase in Females
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Cocktail of Rapamycin, Acarbose and Phenylbutyrate Slows Aging in Mice
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ISRIB - Another Potential Anti-Aging Brain-focused Drug in Testing
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Meclizine (mTOR inhibitor), and GLYLO (supplement combination)
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Gemfibrozil, a lipid-lowering drug, improves damage in a mouse model of aging
IGF-1 Lowering Drugs for Longevity
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Age1 Venture Capital Launches New Youtube Channel on Longevity & Biotech
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Could a rare mutation that causes dwarfism also slow ageing? (Nature)
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A Life-Extension Drug for Big Dogs Is Getting Closer to Reality (Wired)
Anti-Aging Supplements:
- Astaxanthin (Preliminary NIA ITP results suggest a 12% median lifespan improvement in mice)
- Glycine and Gly/NAC
- Protandim, a mixture of botanical extracts that activate Nrf2, extended median lifespan in males only. (7% median lifespan increase)
Other Longevity Strategies (treatments):
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Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area
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Lowering the Cost / Improving Access for Therapeutic Plasma Exchange (Plasmapheresis)
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Harold Katcher (the plasmapheresis person) is the most inspiring late bloomer ever
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Does plasma donation or blood donation also lead to “plasma dilution”?
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Systemic induction of senescence in young mice after single heterochronic blood exchange
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Young Blood for Old Brains and the Quest to Slow Brain Aging & Rate of Aging
Longevity Clinics
Longevity clinics are health optimization and preventative medicine focused healthcare centers that provide health evaluations and early risk identification of potential disease processes. We believe that this preventative focus is the future of healthcare (compared to the “sick care” of today where they wait until you get sick before they do much of anything), but right now the full services are only available to people who want to spend $5,000 to $100,000 per year. Following are some details on perhaps the leading longevity centers in the world today, and the services they offer.
- The Longevity Clinic Will See You Now—for $100,000 (WSJ)
- The quest to legitimize longevity medicine (MIT)
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Longevity Clinics: What They Are, Services & More
Examples of Longevity Clinics (Detailed Presentations on each) - Longevity Clinics: Dr. Andrea Maier, Chi Longevity, Singapore
- Longevity Clinics: Fountain Life, Mona Ezzat – Velinov, MD
- Longevity Clinics: Cleveland Clinic, Wellness and Preventive Medicine, Michael F. Roizen MD
- Longevity Clinics: Human Longevity Inc., Dr. David Karrow
- Longevity Clinics: Dr. Mark Hyman, Function Health (Functional Health seems to focus on health testing, starting at $400 or so for a suite of tests).