Rapamycin User Survey #2 - Please Respond

Please answer each of the 16 Questions we have below:

How Long Have You Been Taking Rapamycin?

  • Under 1 Year
  • 1 to 2 Years
  • 2 to 3 Years
  • 3 to 4 Years
  • 4 to 5 Years
  • 5 to 6 Years
  • Over 6 Years

0 voters

How Old Were You When You Started Rapamycin?

  • 20 to 24 Years
  • 25 to 29 Years
  • 30 to 34 Years
  • 35 to 39 Years
  • 40 to 44 Years
  • 45 to 49 Years
  • 50 to 54 Years
  • 55 to 59 Years
  • 60 to 64 Years
  • 65 to 69 Years
  • 70 to 74 Years
  • 75 to 79 Years
  • 80+ Years

0 voters

If you’ve experienced benefits with Rapamycin, How long, after starting rapamycin, was it before you started noticing benefits?

  • 0 to 3 Months
  • 4 to 6 Months
  • 7 to 12 Months
  • 1 Year to 1.5 Years
  • 1.5 Years to 2 Years
  • 2 Years+

0 voters

If you’ve experienced side effects with Rapamycin, How long after starting rapamycin was it before you started noticing side effects?

  • 0 to 3 Months
  • 4 to 6 Months
  • 7 to 12 Months
  • 1 Year to 1.5 Years
  • 1.5 Years to 2 Years
  • 2 Years+

0 voters

Overall, How would you rate your satisfaction with Rapamycin so far?

  • Very dissatisfied
  • Somewhat dissatisfied
  • Neither dissatisfied or satisfied
  • Somewhat satisfied
  • Very satisfied

0 voters

Given Your Experience With Rapamycin So Far, How Likely is it that You Will Continue to Take it ?

  • Very unlikely
  • Somewhat unlikely
  • Neither likely nor unlikely
  • Somewhat likely
  • Very likely

0 voters

Overall, Given your experience with rapamycin so far, how likely is it that you will recommend Rapamycin use to a friend?

  • Very unlikely
  • Somewhat unlikely
  • Neither likely nor unlikely
  • Somewhat likely
  • Very likely

0 voters

We would like to get a better understanding of the general health of current rapamycin users, and what their total medications and supplement protocol looks like…

What prescription medications do you take for common health conditions?

(choose all that apply) Note: we are Only referring here to drugs that you have been prescribed for a specific medical condition, not drugs that you take for general longevity purposes). For example if you take viagra for ED, check it here in this section. If you take Viagra for Alzheimers prevention, that would be for “longevity” and classified in the following question.

  • Antidiabetic agents
  • Analgesics (pain relief)
  • ACE inhibitors (high blood pressure)
  • Lipid-lowering drugs (high cholesterol)
  • ED (Viagra / Cialis / Tadalafil, Sildenafil, etc.)
  • Antidepressants/Anti-anxiety Medications (Fluoxetine, Citalopram, Sertraline etc.)
  • Proton pump inhibitors (reduce stomach acid)
  • Beta blockers (high blood pressure, heart disease)
  • Sleeping aids (zolpidem, trazodone, zaleplon, etc.)
  • Estradiol (Estrogen Replacement patch or pill)
  • Other

0 voters

What prescription longevity medications and treatments do you currently take or use?

(Choose all that apply):

  • Metformin
  • Acarbose
  • SGLT2 inhibitors (Canagliflozin, empagliflozin, etc.)
  • 17 Alpha Estradiol
  • Viagra / Cialis / Tadalafil, Sildenafil
  • Meclizine
  • Deprenyl
  • GLP-1 agonists (Rybelsus/Semaglutide, Wegovy, etc.)
  • Low Dose Naltrexone (LDN)
  • Senolytics (Dasatinib, etc.)
  • NAD+ injections
  • Peptides (MOTC, SS31, etc.)
  • Testosterone Replacement Therapy (TRT)
  • Blood Donations / Plasma Donations
  • Plasmapheresis
  • Other

0 voters

What is the total number of other (besides rapamycin) Longevity Medications/therapies that you currently take / engage in?

Please add up the total number of longevity medications/treatments you take, from your answer to the previous question, and indicate the total below:

  • One
  • Two
  • Three
  • Four
  • Five
  • Six
  • Seven
  • Eight
  • Nine
  • Ten

0 voters

What other prescription longevity medications / treatments are you most interested in trying next? (choose up to 5 medications/therapies you are most interested in trying)

  • Metformin
  • Acarbose
  • SGLT2 inhibitors (canagliflozin, empagliflozin…)
  • 17-Alpha Estradiol
  • Meclizine
  • Deprenyl
  • Viagra / Cialis / Tadalafil, Sildenafil
  • GLP-1 agonists (Rybelsus/Semaglutide, Wegovy, etc.)
  • Low Dose Naltrexone (LDN)
  • Senolytics (Dasatinib, etc.)
  • NAD+ injections
  • Peptides (MOTC, SS31, etc.)
  • Testosterone Replacement Therapy (TRT)
  • Blood Donations / Plasma Donations
  • Plasmapheresis
  • Other

0 voters

Supplements Taken

I’ve split up the supplement questions below into three sections because the software only allows 20 options for each poll.

Which of the following Nutritional Supplements (capsules, tablets, powders, etc.) do you take regularly?

(Choose all that apply)

  • Aspirin
  • Alpha-Keto Glutarate (AKG)
  • Astaxanthin
  • ECGC (Green Tea Extract)
  • Curcumin
  • Creatine
  • Cocoa Extract (Epicatechin)
  • Cacao (Powder, Nibs, etc.)
  • Fish Oil (Omega 3, 6, etc.)
  • Grape Seed Extract
  • Horny Goat Weed Extract
  • NAD Boosters: NMN (nicotinamide mononucliotide), NR (nicotinamide ribosome), Niacin, Niacinamide)
  • Trimethylglycine (TMG)
  • Quercetin
  • Fisetin
  • Berberine
  • MCT oil (Medium Chain Triglicerides)
  • Collagen Protein
  • Coenzyme Q10 (CoQ10)
  • Vitamin C

0 voters

Which of the following Nutritional Supplements (capsules, tablets, powders, etc.) do you take regularly?

(Choose all that apply)

  • Vitamins A, D, or K
  • Vitamin B (b3, b6, b12, etc.)
  • Apigenin
  • Acetyl-L-carnitine
  • Alpha Lipoic acid
  • Lithium (micro dose)
  • Glycine
  • N-acetylcysteine (NAC)
  • Pterostilbene
  • Malate or malic acid
  • Magnesium
  • Trehalose
  • Glucosamine
  • Plasmalogens
  • Hyaluronic acid (oral supplement)
  • protein powder
  • Ginger
  • Ashwagandha
  • Resveratrol
  • Sulforaphane

0 voters

Which of the following Nutritional Supplements (capsules, tablets, powders, etc.) do you take regularly?

(Choose all that apply)

  • Theanine (L-theanine)
  • Bacopa monnieri
  • Tumeric
  • Piperine
  • PQQ (Pyrroloquinoline quinone)
  • Exogenous Ketones (Juvenescence, etc.)
  • Rhodiola
  • ribose, D-ribose
  • Spirulina
  • Resistant starch
  • Inulin
  • Fucoidan
  • Ginkgo Biloba
  • L-Theanine
  • Urolithin A (or Pomegranate Powder)
  • Ergothionine
  • Mushroom Supplements (Reishi, Lions Mane, etc.)
  • Combination Longevity Supplement Products (e.g. NOVOS, Protandim, etc.)

0 voters

What is the Total Number of Supplements You Take?

Please add up the number of supplements that you take, as indicated in the previous three survey questions, and then indicate below the total number:

  • 1 to 4 Supplements
  • 5 to 9 Supplements
  • 10 to 14 Supplements
  • 15 to 19 Supplements
  • 20 to 24 Supplements
  • 25 to 29 Supplements
  • 30 to 34 Supplements
  • 35 to 39 Supplements
  • 40+ Supplements

0 voters

How Frequently do you get laboratory blood testing to see changes in key blood markers (LDL, HDL, CRP, etc.)

Choose the response below that best represents your blood testing frequency?

  • Every 3 Months
  • Every 6 Months
  • Every 9 Months
  • Every Year
  • Every 2 Years
  • More than 2 Years

0 voters

6 Likes

Taking a shitload of supplements atm but most I’ll just finish and won’t restock.

Supplements I will most likely continue: Creatine, vitamins k2 and d3, magnesium, asthaxanthin, lithium orotate, TMG, beta-alanine, boron, melatonin, trehalose (my espressos tastes great with this)

Supplements I am in doubt about: arginine-akg, glycine, nac, citrulline malate(since I am already on the carnivore diet and eat lots of protein), niacin, q10, ashwaghanda (this worked initially but I believe the effect wears off)

Supplements I quit or will quit: pqq, hmb, alpha lipoic acid, l-theanin, d-aspartic acid, quercetin, fisetin, pterostilbene, resveratrol

Will be adding hyaluronic acid though as an experiment

4 Likes

I have not researched hyaluronic acid much. I came across some information that suggests it might be helpful. Have you seen any human clinical studies that look good?

3 Likes

To be honest I just got this one from YouTube both Brad Stanfield and my nmn experiment have some positive videos with positive human study results. It’s not expensive either, like 18 euro for a 3 month supply. I’ll just give it a try… one of the videos had a link to a study in which people took HA for three months, the before and after pics did look impressive…

4 Likes

Based on results so far I’d say there was a commercial opportunity selling pharma grade 17-Alpha Estradiol…

4 Likes

I only have seen it from a laboratory supplier but I am not willing to take that as it has too many impurities…

In honor of our survey, Harvard University’s homepage is all about aging.

3 Likes

Have been using HA for a long time now in two forms: oral (capsule)cwith my morning smoothie and subcutaneous injections (mesotherapy) for face, neck, chest and hands. The results are (at least visual) are very impressive.

4 Likes

It seems that people are most interested in trying 17-Alpha Estradiol next.

But the availability and safety are still a problem.
Recently, are there any progressions of 17-Alpha Estradiol?

1 Like

Courtesy of Playground OpenAI, Beta version:

I take a pill for energy,
And a capsule for immunity.
A powder for my digestion,
A tablet for my nutrition.

My shelves are full of supplements,
Too many to keep track,
I take them all because I can’t always eat right,
What am I to do?

Softgels and liquids,
Sprays and capsules,
It’s overwhelming,
But I take them all.

A supplement for my heart,
A vitamin for my bones,
A mineral for my brain,
A health booster for my home.

Too many supplements, too little time,
I take them all with faith,
I take them to maintain my health and wellbeing,
It’s the best choice I can make.

8 Likes

New video about supplements not to take. Sinclair is pushing NMN and Reservatrol again. He is really not a good pro to follow. He follows money. Stanfield does not like him, and both from Australia.

2 Likes

In my view Stanfield is a modern day grifter. His intere$t is hip nation bank.

Locate peer-reviewed published by Stanfield in PubMed?{personally I will not waste my time even doing a search)

Locate peer-reviewed published by Sinclair in PubMed?

3 Likes

Assume you mean ‘peer reviewed’?

So your contention is that, to be critical of research, you must be a published scientist in the same field? And by inference we should discount meta analysis performed by unbiased and rigorous sources like Cochrane? And finally, also by inference, that supplementation with Resveratrol has merit?

2 Likes

To make you happy I corrected the per to peer.

I said NOTHING about any compound.

“In my view Stanfield is a modern day grifter. His intere$t is hip nation bank.”

Stanfield is a modern day grifter!

“There are two ways to be fooled. One is to believe what is not true; the other is to refuse to believe what is true.”
~Soren Kierkegaard

What specifically do you disagree with in the video above?

1 Like

Brad is from new Zealand

1 Like

I respectfully disagree. I think he tries and generally does a reasonably good job of presenting the science as he sees it. He’s a young guy, so I don’t think he necessarily has the broadest perspective on the literature that someone else who’s older might have, and he’s more conservative than most of us here (he doesn’t think anyone should be taking rapamycin for longevity yet… but he’s what? 35 years old or something?

And yes, his videos are optimized for attracting attention and getting views… thats marketing on Youtube and most regular youtubers do this, and I guess they do it because it works. I don’t like the style, but I’m not going to judge him too much on the marketing approach. He’s competing for an audience for which that seems to work. I’m not really his audience as I tend to avoid heavily marketed things…

I don’t think Brad Stanfield’s target audience is necessarily the people at this site… I tend to think he’s more targeting the broader generalist audience… people who like the idea of living longer healthier lives but don’t read too much and tend to just jump on trends and hype like resveratrol. I see him providing a good counter balance to companies who hype the latest NMN, etc… with little real longevity research behind it…

10 Likes

Suggest that you add Spermidine to your supplement list…