Here’s an interesting tidbit from Nir Barzilai’s centenarian study. Centenarians have lower IGF-1 levels than is typical. I believe rapamycin will drop IGF1
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Yes - that seems like it night be right… but I can’t find any papers saying that exactly…
Reading his book Age Later
He notes that centenarians have high levels of humanim which also lowers IGF-1.
This appears to align with Blagsklonnys idea of hyperfunction theory of aging.
I see there is a peptide called humanim. Wonder if anyone has experimented with it
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What I recall is that Nir Barzilai’s work showed that centenarians actually have a higher level of IGF1 in their blood, but that they have a protective genetic phenotype that prevents cells from taking up IGF1 and using it. A similar mutation was found in Laron dwarves who are also long lived. It is this inability to use the growth hormone (and protection from its effects) which enables longer life.
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Metformin lowers ifg-1 production in the liver that’s well known in the bodybuilding community