IGF-1 is Lower for Centenarians

Here’s an interesting tidbit from Nir Barzilai’s centenarian study. Centenarians have lower IGF-1 levels than is typical. I believe rapamycin will drop IGF1


Yes - that seems like it night be right… but I can’t find any papers saying that exactly…

Reading his book Age Later
He notes that centenarians have high levels of humanim which also lowers IGF-1.
This appears to align with Blagsklonnys idea of hyperfunction theory of aging.
I see there is a peptide called humanim. Wonder if anyone has experimented with it

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