This website is for people interested in living longer, and healthier lives using the latest longevity medicine and geroscience information.
Here you will find real-world, personal experiences of people who are testing rapamycin (sirolimus) and other medications and therapies that lab and clinical research is suggesting could have a significant positive impact on healthy lifespans.
While our main focus is rapamycin because its the most proven drug for extending healthy lifespans, we are also discussing any potential longevity therapeutics from plasmapheresis and young blood transfusions, to peptides, and gene therapy, and much more. Our core goal is to identify and help translate to practical use any new therapeutic approach to improving healthy longevity.
Our discussion forums are optimized for people who want to discuss the science and medical aspects of new potential longevity therapeutics, and we encourage people with strong scientific predispositions, as well as those with medical and scientific backgrounds to join in the forum and participate vigorously. Our approach here is to “go hard on the science, and light on the people” in our discussions. We encourage people to really evaluate the science behind any new development or study, but be considerate and thoughtful of our other members.
Everyone is welcome here to ask questions and post their experiences (positive or negative) with these medications, but before you do so please use the search feature at the top of the home page to review the discussions that have already taken place. We’ve been up and running as a forum since October, 2021 and so we’ve already discussed most of the new research that has come out and so your question may already be answered. If you can’t find any past discussions that directly address your questions, please add your question to a closely related discussion thread, or start a new topic (see “new topic” button at the top of the forums page) if you like.
Rapamycin is an FDA-approved drug that has been shown to increase lifespan and healthspan (typically 15% to 30%) in every organism tested, from yeast, to worms, to mice and more recently (2024) in monkeys. It is widely considered by geoscientists to be the “gold standard” for health and longevity extending drugs. No other drug has such a success record in life extension.
Not only does rapamycin treatment increase life span but it also delays, or even reverses, nearly every age-related disease or decline in function in which it has been tested in mice, rats, and companion dogs, including cancers, cardiac dysfunction, kidney disease, obesity, cognitive decline, periodontal disease, macular degeneration, muscle loss, stem cell function, and immune senescence. (source)
Join in the discussions and ask questions if you would like to learn more about the benefits, risks and science around these drugs.
We are not medical professionals here, and no medical advice is given here. We are just people sharing our experiences and trying to move the science forward faster. We are open to working with geroscience researchers to help push the clinical science forward, and are also patient advocates hoping to push the FDA forward towards a more “health maintenance” perspective vs. its historical disease focus.
Given the low cost of rapamycin, and significant benefits demonstrated in the lab, we think it has the chance to significantly and positively impact public health. We hope the national health care systems of the world will start supporting a more preventative medicine oriented approach that includes testing and making longevity medicines available at low cost to everyone for longer and healthier lives.
If you’re new here - the best place to start is our list of Rapamycin frequently asked questions (FAQ).
