I was using Dr. Reddy - Sirolimus with Cigna Insurance… now with Anthem… using Greenstone Rapamune… will see dose in blood in a few days from a blood test.
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Greg thanks for that information , I am in Canada and I haven’t heard of or located a doctor like Dr Green \ my GP is good but like most of them is not focused on healthspan
so I’m thinking I will have to go w India
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thanks Admin
appreciated
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Hello Greg, I’ve been reading this thread and thought that I would ask you a few questions.
Can you tell me how to contact Dr Green? Does he do telehealth for out of state folks? I am assuming that he is not in Illinois where I am located.
I live 40 miles West of Chicago, and I’ve looked, but under what specific specialty do I look to find a Dr like Mr Green? Loyola University Hospital has a geriatric group, and the subject of taking rapamycin is age related but I think that I’m using the wrong search criteria.
Due to what I’ve read on this site regarding bioavailability / absorption I think I’d like to stick with Rapamune. How hard is it to get Dr Green to prescribe that? I think that you said Dr. Reddy’s is good rapamycin and that you get it from Little Neck Pharmacy. Is that in Arkansas? Does it have a coating on it?
Thank you for your responses ahead of time!
I asked OpenAI GPT-4 the following question and it points me in the general direction. Thought that I would share the information with all of you. If this is not correct information, then please correct it.
Q: Which specific type of doctor might discuss with me the benefits of Rapamune for anti-aging and write a prescription for me?
Rapamune (sirolimus) is an immunosuppressive drug originally used to prevent organ rejection in transplant patients. Some research suggests it may have potential anti-aging benefits. However, it is not yet an FDA-approved treatment for anti-aging, so it’s essential to approach this topic with caution.
If you’re interested in discussing the use of Rapamune for anti-aging, consider talking to the following types of doctors:
- Geriatrician: A geriatrician specializes in the healthcare of older adults and may have knowledge of potential anti-aging therapies.
- Endocrinologist: An endocrinologist specializes in hormone-related conditions and may have insights into the potential impact of Rapamune on the aging process.
- Internal Medicine Specialist: An internist focuses on the diagnosis, treatment, and prevention of adult diseases and may be able to discuss the potential benefits and risks of Rapamune for anti-aging.
Please note that prescribing Rapamune for anti-aging purposes would be considered “off-label” use, meaning it is not FDA-approved for this specific indication. As such, some physicians may be reluctant to prescribe it for this purpose. It is essential to have a thorough discussion with your doctor about the potential risks, benefits, and alternatives before considering using Rapamune for anti-aging.
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Dr. Alan Green is based in NY. You have to to there. See our list of doctors here: Rapamycin Prescription, Doctors that Prescribe It
Rapamune is expensive - see the pricing here: How to buy Rapamycin (Sirolimus)? What is the cost?
Most of your questions are already covered here: Rapamycin Frequently Asked Questions (FAQ)
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Chat GPT is not very good when it comes to longevity and rapamycin… don’t rely on it, it makes stuff up all the time (cites references/papers that are not actually things that have ever been published, etc.).
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ChatGPT is great if you are writing code, a piece of fiction, or a highschool book report.
It’s not so great when you want detailed, factual, and reliable information about a specific advanced topic. Rapamycin use would be one of those advanced topics.
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Thanks all!!!
Tons of information here.
All of Dr. Greens info found at www.rapamycintherapy.com
First visit in person, by law, and televisits thereafter.
First listen to the Rapamycin Master Series podcast find here on this site to best understand his approach and yes he takes me patients. I traveled to NYC in 2018 for my first visit. The Littleneck Pharmacy is right there near Dr. Green’s sparse home office. I encourage you to go… he’s a sharp at 80 as he was at 75 when i first met him. Let me know what else you need.
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The podcast is an interview with Dr. GREEN. There is a first podcast as well with a pharmacist. Also good.
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Hi Larry!
I am also in my late 60s and interested in using Rapamycin for its potential anti-aging benefits. Regarding your question about older folks needing higher doses of Rapamycin, there is currently no consensus on the optimal dose of Rapamycin for anti-aging purposes. It’s true that some studies have suggested that higher doses of Rapamycin may increase the risk of side effects such as elevated lipids. However, other studies have not found this to be the case.
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Escalate your dose by 1mg per week over a month starting at 2mg/week. eg. Start at 2mg per week for a month then go to 3mg … perhaps make the escalation time 6 weeks. Assess at 10mg. Be sure to base line your blood work. A1c, lipids, are particularly important to track, so do so at the start, then midway, then 60 days after you’ve maintained that 10mg.
If like myself you found you need statins, take the lowest possible effective dose to stay just in range. I’ve been on R for over 5 years and currently taking 12mg/week having started in 2018 on 3mg/week.
A bit controversially i take it with grape fruit juice that triples the 4mg actual dose i currently take. Do your research if you go this route and be aware it can escalate the effective dose of many other meds.
Also is noted that metformin is synergistic with R. I take 2 500mg tabs ER daily.
I’m fortunate in that R relieves about 70% of my painful hand arthritis. So i know if the supplier is providing a dilute pill.
So be sure to only buy from a manufacturer that is FDA approved supplier of Sirolimus, if you do not buy Pfizer brand Rapamune. India’s Dr. REDDY brand was approved by the FDA as a generic brand of Rapamune. Best of luck. Go slow, start small, measure.
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I think Greg has provided excellent information here. The only thing I might challenge him on (and even this is not a very significant difference of opinion), is that I think that Biocon and Zydus from India are reasonable choices of suppliers for people who are cost-conscious or on fixed income. The lab analyses I’ve seen suggest the quality is pretty good: Rapamycin / Sirolimus from India, Lab Test Report on Quality / Purity
And Dr. Reddy’s, while FDA approved, doesn’t have a stellar record… they had a big recall on sirolius in 2016: Dr Reddy’s recalls 9,330 bottles of Sirolimus tablets in US | Mint
New Delhi: Pharma major Dr Reddy’s Laboratories is recalling 9,330 bottles of Sirolimus tablets, used for prevention of organ rejection after kidney transplant, in the US due to presence of impurities.
According to the latest Enforcement Report of United States Food and Drug Administration (USFDA), Dr Reddy’s US arm Dr Reddy’s Laboratories Inc is recalling 9,330 bottles of Sirolimus tablets, 1 mg on account of failed impurities.
The reason for recall is “failed impurities/degradation: out of specification result for impurity secorapamycin," the report said. The voluntary nationwide ongoing recall is a class III recall, it added.
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Excellent and informative. Thank you for the information.
Yes, I would say that Zydus and Biocon are better brands than Dr. Reddys. I have used both and they are effective.
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Good points for Dr. Reddy, I have found several pharmacies that use it as it is FDA approved list for a sirolimus generic as is Zydus. Biocon does not appear to make the FDA list. I only am critical as it did not present the benefit to my known issues…I had to take 8x the normal amount of Biocon to get the benefit.
I guess the only objective guideline, and only way to eliminate my subjective experience, is to stick to what is FDA approved provider list for generic Rapamycin…called Sirolimus. Dr. Reddy is still listed. And being monitored as your article clearly shows, so maybe they are on their toes! Zydus is the most recently approved FDA listed generic provider…since 2014 I believe.
My primary message to all is to stick to the list. I pay more for it, but better than paying 30% of the normal price and getting 5% of the benefit.
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GregE I appreciate your experience, especially with the length of time you’ve been taking Rapa.
I’d be curious if your sirolimus blood levels correlate with your subjective experience as to which are more potent? It’s possible coatings have different efficacy and the Dr. Reddy version is more readily absorbed in your system. It’s also possible this could be unique to your physiology. However, I would think that a blood level of 10 ng/ml with one manufacturer should produce the same effect as a blood level of 10 ng/ml from another manufacturer.
I think everyone should do some initial testing (either at 2 hours post ingestion or 12 hours and compare levels to the graphs in the published studies of dosing in healthy individuals to confirm they aren’t an outlier in terms of absorption. As you say it is a small price to pay to be sure you are actually getting the medication under the conditions that you happen to be taking it.
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Thanks for this 
Because any failure of dose efficacy of an FDA approved provider of generic Rapamycin for transplant patients would result in a widely noted increase in mortality, I rest assured that the Dr. Reddy (and 3 other FDA approved) brands are delivering what’s expected. As i may have mentioned, i stated on 1mg the first year, 2mg the 2nd, 3rd, and 4th year… and 3-4mg this 5th year. Now also recall i take this with 8oz of GF Juice, and expect a 3x increase in blood levels of this med.
Strangely my PSA which rose over 4yrs from 1.9 to 6 (this last Sept) due to a non aggressive (Gleeson = 6) adenocarcinoma of the prostate (biopsied 2019) has dropped 6mon ago to 2.6 and 2.1 (last week). Not sure the improvement will last but Dr. Green upped my dose recommendation to 10mg…9mos ago… to show the progression.
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