- Increased median lifespan in the male mice by 14%, maximum extension of 9%
- But had no effect on the females
Canagliflozin is in the class of drugs known as SGLT2 inhibitors. SGLT2 inhibitors have been commercially available for over 10 years and they are used commonly in patients with type 2 diabetes as it blocks the re-uptake of glucose so that more glucose is excreted in the urine. They affect the process in the kidney that deals with very high glucose levels without having much scope for causing toxicity, so are safe from causing hypoglycemia.
While canagliflozin was the drug tested in these ITP studies, it is likely (but not yet proven) that all the drugs in the SGLT2 class of drugs provide the similar benefit of life-extension. The other SGLT2 inhibitor drugs (generic / brand names, and combinations with other drugs) are as follows:
- canagliflozin/metformin (Invokamet)
- canagliflozin/metformin extended release (Invokamet XR)
- dapagliflozin Farxiga
- dapagliflozin/metformin extended release (Xigduo XR)
- dapagliflozin/saxagliptin (Qtern)
- empagliflozin (Jardiance)
- empagliflozin/linagliptin (Glyxambi)
- empagliflozin/metformin (Synjardy)
- empagliflozin/metformin extended release (Synjardy XR)
- ertugliflozin (Steglatro)
- ertugliflozin/metformin (Segluromet)
- ertugliflozin/sitagliptin (Steglujan)
What could explain the sex-specific difference in the effect on lifespan?
The following information is sourced from the Peter Attia / Richard Miller podcast. Richard Miller suggested that when you take these canagliflozin results together with the acarbose results, you’re led to the inference that something about aging in the male mice depends a lot on staying away from really high glucose levels. However, whether that means that high glucose in the males triggers a circuit in the hypothalamus, which is bad for you or something, is just a hypothesis. It may be that it has to do with the susceptibility of the hypothalamus to inflammatory change differentially in males than in females. And this nebulous change has an impact on the cancer, or an impact on anti-cancer defenses or something. Rich Miller believes that these hypotheses are equally likely to be true, but at present, none of it gives us much of a hint as to why these drugs have a much more striking effect in the male mice
Graphical abstract of blood glucose response. [source]
Did Rich Miller see the same effect in Canagliflozin that they saw with acarbose in that the hemoglobin A1C was unaffected?
Rich’s recollection is that there was no difference in the effect on hemoglobin A1C in mice. This is surprising because it is affected in human diabetics.
Summarizing what we know about canagliflozin :
- We don’t know whether the positive effect of canagliflozin is due to its impact on glucose, SGLT2, or SGLT1
- The literature is showing, for example, that SLGT-2 inhibitors have an effect on tumors specifically, and other things like heart attacks, independent of whatever’s happening in terms of glycemic control
- The shortest, simplest explanation—that the benefits are due to canagliflozin’s effect on glucose—may not be right. — “There are other ideas that deserve a lot of exploration .”
- Peter Attia has said he is excited about the data coming out around canagliflozin : “We are very excited about this class of drugs clinically in our practice; the cardioprotection, renal protection, obviously the glycaemic benefits are all pretty exciting.”
Personal Experience and Observation with Using Canagliflozin for Anti-aging:
I have found that using canagliflozin (while taking rapamycin) for anti-aging is very effective in moderating glucose spikes. I use a continuous glucose monitor and while I was using canagliflozin my blood sugar levels seem to be well-moderated and mostly kept within the range of 80 to 110 mg/dL (approx. 3.9 and 6.0 mmol/L). I successfully tried canagliflozin for approximately 3 months and thought it was working well. However, at some point it became obvious I was suffering from an abnormal level of exhaustion and I stopped taking it - which I’ve reported on here:
Canagliflozin for Anti-aging - One Month and 4 Month Updates
Brand Name Product:
Canagliflozin (Invokana) Average Street Price: $650 for 30 x 300 mg tablets ($21 per 300 mg tablet)
GoodRx Discounted Canagliflozin (Invokana) Price: $550 for 30 x 1 mg tablets ($18 per 1 mg tablet)
Generic: Generic version of Canagliflozin Not Available Yet
(you can check current prices yourself via Indiamart.com - search on “Canagliflozin” for example.
Current exchange rate India Rupees to US $ is around 75:1 based on this currency exchange calculator
Approximate India Pricing:
Canagliflozin (Invokana) Price High: 1500 rupees for 10 tablets of 300 mg (approx. $2.00 per tablet
Canagliflozin (Invokana) Price Low: 1200 rupees for 10 tablets of 300 mg (approx. $1.60 per tablet)
Canagliflozin (Invokana) Price High: 700 rupees for 10 tablets of 100 mg (approx. $0.93 per tablet
Canagliflozin (Invokana) Price Low: 500 rupees for 10 tablets of 100 mg (approx. $0.66 per tablet)
Note: The India pharmacies have been amazingly good as far as delivering the medicines they promise. We’ve spoken to a many people who have ordered their medicines from India Pharmacies and everyone have had good experiences and always have received the medicine that they ordered. The only exceptions being that a couple of times people’s orders have been held up or blocked at US customs.
Most people taking Canagliflozin for anti-aging purposes report taking somewhere between 100mg per day (one dose per day) and 300mg per day (one dose per day) - taken once in the morning.
Cost of One Year of Canagliflozin:
The cost at the USA high end for 360 tablets, Canaglifliozin (Invokana) 300mg, is $7,800+
The cost at the USA mid-range for 360 tablets, Canaglifliozin (Invokana) 300mg, is $6,600+
The cost at the India mid-range for 360 tablets, Canaglifliozin (Invokana) 300mg , is $720
The cost at the India Low end for 360 tablets, Canaglifliozin (Invokana) 300mg, is around $576
The cost at the India mid-range for 360 tablets, Canaglifliozin (Invokana) 100mg , is $334
The cost at the India Low end for 360 tablets, Canaglifliozin (Invokana) 100mg, is around $237
Read the Research Paper on the Canagliflozin Longevity Study done by the ITP:
jciinsight-5-140019.pdf (1.5 MB)