After spending most of my “filler time” reading through nearly all the forum posts on this site, I’ve ordered 150mg of Sirolimus (Zydus) via IndiaPost.
I’m 37yo male, an engineer, with wife & 3 kids. But Rapamycin isn’t for me, it’s for my parents (although I probably will try it to see if it helps with a right knee which is starting to ‘zing’ during 5+ mile runs, and some lower back pain–not holding my breath though).
I got Peter Attia’s new book Outlive for my parents and they read it very fast (not being big readers). My mom is 70 and my dad is 73. Neither of my parents drink much alcohol, and they eat pretty darn healthy–abundance of vegetables, supplements, etc etc. Generally health-conscious people, but nothing overboard. They both work out extensively–mom: Barre3 daily; dad: long 2-3 hour sessions at the gym 3-4 times a week. However, previous to reading Outlive, he wasn’t super detailed about his heart rate zones, and likely far too much aerobic vs resistance training. Now he’s mixing both aerobic & resistance training and better optimizing his time at the gym because of Outlive book.
Then came the Rapamycin chapter. Both were immediately excited to try it. My mom (70yo) talked with her doctor (45yo female) and the Dr., surprisingly, expressed her excitement, and how she listens to Peter Attia, Huberman, and Mathew Walker all the time on her drive to work. My mom didn’t ask for a Rapamune prescription, but likely could’ve gotten it prescribed had she not said, “My son is getting Sirolimus for me.” I sent a list of things for her Dr. to watch out for (thanks to this forum) and it sounds like her Dr. is on it. So I feel comfortable now with a real Dr. involved, and one that has been following my mom’s health journey for 10+ years… so it’s not just me tinkering w/my parents health (no matter how many videos of Matt’s, Peter, Dr. Alan Green, etc etc I’ve watched).
My dad’s main thing, and really, biggest love, is Golf, then with Pickleball in a close 2nd. Without those 2 things, my dad’s life & happiness would probably drop in half, or more. At 73, he’s starting to really feel it, and he is afraid he may have to give up golf this summer (golf season really picks up June - September here, in the Pacific Northwest). So, this is a perfect timed test/experiment, with a goal set. Get my dad on a dosing schedule, slowly ramping up (I’m going to try 14-day intervals due to the high half-life of Sirolimus), and see if he turns around fast enough for his golf game to continue for another 10 years+ instead of stopping at only 73.
After reading through all the great self-experimenters on this forum, & keeping side effects in check, and mTORC2 in check in reference to the long half-life, I’m thinking of this dosing schedule:
73yo Dad, 175lbs
- Week 1 - 1mg
- Week 2 - 2mg
- Week 3 - 3mg
- Week 4 - 4mg
- Week 5 - 0mg
- Week 6 - 5mg
- Week 7 - 0mg
- Week 8 - 5mg
- Week 9 - 0mg
- Week 10 - 5mg
- Week 11 - 0mg
- Week 12 - 5mg
- Week 13 - 0mg
- Week 14 - 5mg
It will then be the beginning of August, and hope his golf game is in full swing!
For my mom, essentially the same thing, but I’m going to stop her at 4mg peak dose every 2 weeks since she is roughly 25% less mass than my dad.
Additionally, we have a Golden Doodle (Oliver) that just turned 8, and for the first time, damnit, is starting to go much slower as he ‘pulls’ himself up on our couch. I am going to get him up to 6mg/week (per Ageing Dog Project dosing), since the half-life in dogs is about 40 hrs (compared to around 60hrs for humans). Maybe just do it for 8 weeks or so and see how he is doing.
My brother’s dog is 9yrs old, girl, and has cancer. I was thinking of getting her on it, but I fear I don’t want to get too involved with that, as the vet said she only has 6 more months to live, the tumor is large, and the studies are a bit mixed on the efficacy of Rapamycin on cancer after it has grown to this size. But I’m all ears to any and all feedback.
Anyway - there ya go. Thought I’d share what I’m up to and not just consume all this great knowledge without giving something back to the community. I’ll update this with any big milestones, or side effects (good or bad!). Shoot any holes in anything you see here.
Thank you so very much,