This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age, defined in our work as a deregulation (noise) of 10 novel protein biomarkers. The results on biological age are strongly supported by the data, which demonstrates that rounds of therapeutic plasma exchange (TPE) promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators and a youthful profile of myeloid/lymphoid markers in circulating cells, which have reduced cellular senescence and lower DNA damage. Mechanistically, the circulatory regulators of the JAK-STAT, MAPK, TGF-beta, NF-κB, and Toll-like receptor signaling pathways become more youthfully balanced through normalization of TLR4, which we define as a nodal point of this molecular rejuvenation. The significance of our findings is confirmed through big-data gene expression studies
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I believe we discussed this in another thread and that the results from people who had the treatment were within ‘noise’ levels. This meant that there was not a statistically significant reduction in epigenetic age, unlike Glycine or Rapamycin or others trialed by the ITP.
Honestly, you get way more bang for the buck by adding a spoonful of glycine to your morning coffee.
Now, if they could show a large, statistically significant result, then I would consider it. But for now, it doesn’t seem like a good option to me from either a cost or effectiveness standpoint.
When you donate whole blood, nothing is returned. Your blood volume has been diminished by 1 unit.
When you donate plasma, your cells are returned to you suspended in saline with a little anticoagulant. So your blood volume is unchanged but everything in it is slightly diluted.
I hadn’t heard of Glycine until I read your article, so I researched it,. It certainly seems to be a very important amino acid acid , particularly to increase glutathione. I take Readi Sorb liposomin Glutathione which is probably more effective than Glycine… in my research of Glycine, there was no mention of it being an anti aging supplement. However, I was interested in it’s effects on blood sugar and insulin so I will order this.
I have heard that taking liposomal glutathione may not be a good thing as your body cannot regulate the levels of glutathione directly. Therefore you may be overdosing on glutathione. If you take the precursors to glutathione, glycine + NAC, your body can make as much glutathione as needed. That’s what I do. Dr. Brad Stanfield mentioned it in the his video below on taking liposomal glutathione.