37M, generally in good health. Exercise regularly (weights and cardio) and eat a moderate low-carb(ish) diet. Not much to comment on here.
Vitamin D - 5000iu 3x // week during winter
Acetyl-Carnitine — 1-2g, 5x per week
KSM-66 ashwagandha — 600mg 4-5x per week (or as needed for stress)
NMN - 250mg-500mg on occasion when I need an energy boost. I do find this works for me acutely better than chronically.
I had started astaxanthin again but dropped it as I didn’t want to change any variables from what I had been taking previously.
Week 1 (Monday, Dec 5):
I’m writing this retrospectively, I took 2mg with 6mg piperine (inhibitor of CYP3A4). I noticed some fatigue later in the day and took a nap. Felt great the next several days.
Perhaps noticing some increased soreness from exercise in the days following. Not quite as much energy in the gym for a day or two.
Overall pretty mild effects, think I maybe psyched myself out.
Week 2 (December 12):
Took 5mg this morning with 12mg piperine. Felt more comfortable bumping the dosage after I didn’t really react to 2mg. Might switch to grapefruit juice but I hate the stuff and I have piperine on hand. It’s a bit unclear to me how much the piperine increases the absorption though, I’d rather have some concrete numbers. Probably best to get a blood level sirolimus test at some point.
Noticing mild fatigue again. Really seems pretty mild though, if I didn’t know that I took rapa today I probably wouldn’t have noticed much.
Will continue taking it at this dosage (5mg // week, likely with some sort of absorption enhancer).
Bloodwork to follow in the next couple weeks. I’ve had no side effects thus far, but it’s quite early so I’ll update if that changes.