I’m a new user here, but have been enjoying reading this forum for quite a while. Hope its OK for me to create a new topic for this - couldn’t find an existing topic that really matched.
I’m 53 and been interested in this subject ever since reading David Sinclairs book on anti-aging some years ago. Been researching the subject for quite some time now and was excited to find this forum a year ago and find that Rapamycin is actually a viable option (was well aware of it, but thought it came with all sorts of dangerous side effects…)
I finally managed (with some cajoling of my Doctor to write a prescription) to purchase some Biocon Sirolimus from India (tried for Zydus, but not available currently) and after some hiccups with customs, finally got them.
I have taken just 2 doses of 1mg so far, a week apart (in morning with breakfast of oatmeal). Based on comments here I was not expecting to notice anything, but I definitely did and was wondering if some of these experiences I’ve had are normal.
Both times I had extreme jitteryness on the day taking it - like a high anxiety, yet my heart rate was if anything lower than normal. Plus a strange sense of smell and taste.
These side-effects were gone the next day. I read it can be somewhat ‘stimulatory’, but am glad I started at just 1mg, because I couldn’t handle a higher level of that buzz!
My sleep quality (as recorded by my Garmin) has dramatically improved from the day I started (the jitteryness had no bad effect on sleep). I haven’t been sleeping well for a while now (some challenging personal/family issues am dealing with), with sleep scores from 40 to 70. But straight after first dose my sleep went to averaging 80+ and last night 91 - best score I’ve had in a year or more. No waking up lots of times during the night. Remarkable.
Resting HR also dropped a few points. Went to gym to do weights today and was feeling strongest I can remember.
Really wasn’t expecting such instant effects, and on such a low dose. Does this make sense?
I also take Metformin and venlafaxine (for depression I’ve had for many years), plus a whole set of other stuff like NMN, pterostilbene, reseveratrol, spermidine, bio piperine, plant sterols, fish oil, Vitamin D, DHEA , garlic supplement, folic acid (most of these after tracking my blood indicators on Inside Tracker). Frankly I’ve never noticed ANY effects from the NMN/pterostilbene/reseveratrol combination I’ve been taking for years - either feeling wise or on my metrics (Garmin or blood tests).
Am wondering if I’m getting some sort of interaction effects with other stuff that would give me such strong jitters on just 1mg?
Should I just stay at 1mg for now until this ‘wear’s off’, before going higher?
Any advice appreciated :-).