We’d like to get an updated idea of the exact dosing protocols, and successes or problems our members here are experiencing. Please respond to each poll as you scroll down this thread. There are a total of 4 different survey questions as you scroll down. Please answer them all, to the best of your knowledge.
What amount of rapamycin do you take for each dose?
(note: choose the closest mg choice to what you take. if you are taking rapamycin with GFJ, then calculate the effective rapamycin dose by multiplying your rapamycin dose by 3X to come up with an approximate effective rapamycin dose)
Maybe more specificity on the blood measures- e.g. my HDL and LDL numbers stayed good or slightly improved, but my triglycerides went up noticeably. (Every other measure is good)
Given your ideas… here are some other questions. Not sure exactly how to structure the question about “how we are taking” rapamycin… some are mutually exclusive, some not, so it gets a little weird…
Keep the ideas flowing… what else do we want to know about our rapamycin use and results?
Here are some of what I’ve pulled together given the feedback and with a little more thought on the matter:
What version of rapamycin / rapalog do you currently use?
Pfizer Rapamune
Glenmark Pharmaceuticals Sirolimus
Zydus Siromus
Biocon Rapacan
Rocas Sirolimus
Panacea Biotec - Siropan sirolimus
Actiza Sirolimus
Dr. Reddy’s Sirolimus
Sirolimus from a compounding pharmacy
Everolimus
How do you typically take your rapamycin / rapalog?
With grapefruit juice
Olive oil, or other fatty meal?
Empty stomach,
Morning
Evening
How would you rate your experience with Rapamycin so far?
Scale of 1 to 5 with 5 being fantastic, 1 being terrible?
Given your experience with rapamycin so far, would you recommend Rapamycin use to a friend?
Yes / No
I think questions 1 and 2 could be amalgamated so we can parse out the true range of mg/wk… Actually I think it would be most helpful to know mg/kg/wk:
< 0.05mg/kg/wk
0.05 to 0.1mg/kg/wk
0.1 to 0.15mg/kg/wk
0.15 to 0.2mg/kg/wk
0.2 to 0.3mg/kg/wk
Over 0.3mg/kg/wk
It would also be interesting to understand the significance / duration of the side effects. Its one thing if someone gets one mouth sore once (as I have - just once over the past 3 years) vs. say once every month. I think most of the side effects are short term, temporary and rarely return. The way the poll is setup right now - we can’t tell if the side effect was a one time occurrence and minor, or recurring and problematic.
So maybe a question about how significant a problem the side effects are…
From 1 to 10, with 1 being short-term and insignificant, and 10 being ongoing, frequent, and painful or serious.
Yes, I wasn’t sure how to answer the “side effects” question. I had one shocking day after taking 2mg the first time, but nothing that bad since. I found that, if I take Sirolimus in the evening, next morning I sometimes feel like I have a hangover…but I don’t drink. (Just feels like I drank a bottle of some rotgut spirit.) Now I take it with breakfast and I don’t get that “hangover” feeling.