What do you think about the idea of a friendly, “biological age reduction” competition that helps us all get healthier and more knowledgeable…
This week I saw that one person has reported great results with rapamycin in terms of biological age reduction:
Has anyone lowered their levine age or aging.ai through Rapamycin? yes, had blood tests and epigenetic age test done before starting rapamycin and after. Took rapamycin at 6mg/week for 4 months. 13 years improvement by Levine calcs as well as epiagingusa test.
To be honest, I’m very surprised by this result because the study on the rapamycin treated marmosets showed negative results. But - as many researchers pointed out - it was one type of epigenetic test (and in general people are still questioning the value of these tests and what they actually measure), and one short term study… so it doesn’t mean much. I’m skeptical about the above person’s measures - they seem too good to be true (and probably are), but lets see if we can validate it, or prove it wrong, with more examples from more people taking rapamycin…
In theory, it seems that since rapamycin has reversed or slowed aging in every organism its been tested on, we should see some sort of biological clock impact from taking rapamycin… but its never been shown in humans (so far, in research, that I’m aware of). So, if we do show a consistent biological age reduction by our use of rapamycin it would be very interesting, and good news.
My personal results might seem to support the idea that rapamycin could help with measurable biological age reductions - since I’m showing about 15 year lower biological age vs. chronological age as measured by the Levine phenotypical calculator. But I didn’t do pre/post testing so who knows what is helping me in this area? Or maybe these phenotypic calculations don’t measure what we think they measure.
So - to test this idea out - that rapamycin, and other lifestyle interventions help us lower our biological age - How about a Levine Phenotypic age calculation contest? Anyone with me on this?
This would work on the honor system, with no prizes yet (perhaps I can get sponsored by Lifespan.io for Starbucks gift cards for quarterly winners
Here is how it might work (I’m open to other suggestions and other ideas):
- People get the CBC and CRP blood tests so they have the information required for the Levine Phenotypic calculations.
- We all report our Levine Biological age to start
- Then we report every quarter (or whenever you want to participate)
The blood tests you need for this calculation are:
- Complete Blood Count (CBC) / Chemistry / Lipids Panel Blood Test ($45)
- C-Reactive Protein (CRP), Cardiac Blood Test ($42)
And we announce quarterly winners in two categories:
- Greatest Biological Age Reduction Overall (e.g. your chronological age minus your most recent biological age / blood test results)
- Best improved on a monthly basis (e.g. total biological age improvement since your last biological age calculations/blood test divided by the number of months since your last blood test)
What are Thoughts? Please click on the “Reply” button below and let me know if you like it and would participate?
I suggest we use these two free methods of calculating biological age:
- The Levine Phenotypic Age Calculator by Morgan Levine/Yale University
- The Aging.ai version 3.0 online calculator: http://aging.ai
Attached below is the .xls spreadsheet that I think Mike Lustgarten created for easy, at home calculation of your Levine phenotypic age.
3ba41-dnamphenoage_gen-1.xls (31.5 KB)
A little more reading if you’re new to the Levine Phenotypic Age Calculator: