Rapamycin Update - What You Need To Know (Modern Healthspan)

[RapAdmin]

Rapamycin Update What You Need To Know | Prof Matt Kaeberlein Ep1

and the paper that is mentioned at the beginning:

Evaluation of Off-label Rapamycin use to Promote Healthspan in 333 Adults (New Paper)

The new paper that is based on the survey (that many here particpated in) on rapamycin use in healthy people, is now out and open access. If you are new to rapamycin and want to talk your regular doctor about getting a prescription for rapamycin, this would be my vote for one of the papers to include in the information you give him or her. Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and healthspan metrics in yeast, invertebrates, and rodents. Several physicians are now prescribing rapamycin off-label as a preventative therapy to maintain healthspan. Thus far, however, there is limited data available on side effects or efficacy associated with use of rapamycin in this context. To begin to address this gap in knowledge, we collected data from 333 adults with a history of off-label use of rapamycin by survey. Similar data were also collected from 172 adults who had …

Results from this study are very similar to what we have seen in our own user surveys here on our site:

Surveys & Polls of Rapamycin Users

• Rapamycin User Poll / Survey: Dosing Frequency, Dose Level, Benefits, Side effects, etc.
• Rapamycin User Survey #2: How Long Taken Rapamycin, How Old When Started, Timing of Benefits and Side Effects, Other Longevity Drugs and Supplements, etc.

Full Rapamycin FAQ here: Rapamycin Frequently Asked Questions (FAQ)

[RapAdmin]

Taurine vs Rapamycin | Prof Matt Kaeberlein Ep2

[Elizabeth_Kirby]

I just watched the video with MK talking about the rapa study: https://www.youtube.com/watch?v=vgoYKF32jBc&list=PLkfzM7KJv6vYWOR99_hK0-7AGTRr2QomZ

Richard asks MK towards the end about bring rapa more mainstream. MK replies that the better but more unlikely way would be an actual study, but what seems to be happening is biohacking.

He says there are two barriers to the study: (lack of) profit & that rapa has a bad rep.

I think he said the point of the worm bot is to test a lot of compounds & see what works as well & hopefully better than rapa. That might solve both those problems – they might find something that is still under patent or could be tweaked to be new & because it’s more or less new, would be able to leave the perceived stink of rapa behind.

So there is hope that something will come up eventually …or so I like to think.

[RapAdmin]

Update on the Dog Aging Project. Sadly, it sounds like another 3 or 4 years before any rapamycin results available…

Dog Aging Project Update | Prof Matt Kaeberlein Ep3

[RapAdmin]

and part 4:

The Million Molecule Challenge To Find The Next Longevity Treatment | Prof Matt Kaeberlein Ep4

[RapAdmin]

a recent discussion on twitter unrolled, on the million molecule challenge. (Note: Karl is an ex-Google AI guy, and leading angel investor in the longevity biotech space in the SF Bay Area). Source of twitter thread here.

And a link to Jose (second to last post in the above thread) document:

Nintil - Beyond lifespan as a metric in aging research: why reprogramming is...

[RapAdmin]

Lifestyle Interventions For Healthspan | Prof Matt Kaeberlein Ep5

[KarlT]

Very interesting stuff. I’m sometimes a bit leery of data from worms and flies. It seems like almost anything shocks their system and they live 10% longer. But if it moves forward to mice, could be helpful.