For people who like data, the attached document is the full list, compiled by Dudley Lamming, of all the mouse studies that have been done with rapamycin and which show life extension (only a few studies, in rare genetic backgrounds have not shown lifespan improvement). Rapamycin is by far the most rigorously studied compound that consistently and significantly increases lifespan and healthspan.
Additional to the below list of all the rapamycin mouse studies is this Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse.
Full List of Rapamycin Mouse Life Extension Studies (PDF) below:
preprints202102.0491.v1-6.pdf (391.7 KB)