Rapamycin here in Canada is prohibitively expensive. Quoted Rapamune, $1000CDN for 100 x 1mg tablets, or $8 USD/mg. So I started to search for alternate sourcing. Thankfully, a fairly robust online community of bio-hackers had paved the way.
When I started Rapamycin back in January 2021, some posters in another forum vouched for a capsulized product out of Austrialia: http://rapamycin.store/ (30 capsules @ 4mg/capsule, approx $1 US/mg delivered). I had ordered/consumed several several batches. For the past 4 weeks, I upped me dose to “18mg” with GFJ per week, no significant side effects.
As the year progressed, I considered alternative sourcing. Some other posters have vouched (3rd party analysis, personal side effects) for Rapamycin sourced from http://www.hhdpharm.cn/en-us/ (WHP)
I was quoted:
USD$60 Per 1000mg
USD$120 Per 2000mg
USD$300 Per 5000mg
+$50 for shipping, and any wire fees (typically $15 USD).
Good service, easy to deal with.
I lost my first 1g shipment to Customs, but ordered a 2nd shipment (I redirected from WHP to a business contact in China, who repackaged, on-forwarded to me) of 4000mg for $220 delivered, or USD, $0.055/mg. They gave me a deal on 2nd order to compensate for the lost shipment.
My contact: email@example.com (Sophia Jiang)
Wanting to make certain the powdered sample was indeed Rapamycin and had no other safety concern contaminants, I sent it out to a local 3rd party lab for mass spectrophotometry. I also sent out a 6mg capsule (a custom capsule order) from http://rapamycin.store/
The test cost me $200 CDN per sample (approx $160 USD)
The results of the scan on the WHP sample attached.
- The WHP sample is definitely Rapamycin. There are some additional signals indicative of product degradation (per lab). Sirolimus powder, unstabilized (eg a conjugated salt form for stability), must be stored at -20C to prevent degradation. Testing lab confirmed same re storage for Rapamycin powder. My sample, based on the testing, is likely 85-90% Rapamycin, rest is degradation products of Rapamycin (approx 6 weeks out of cold storage from vendor). No signal for any other significant contaminants or unsafe molecules indicated. I have my sample in the home freezer, which should be about -15/-20C.
" storage temp. −20°C"
- The rapamycin.store sample also confirmed Rapamycin (results not posted). Impossible for lab to confirm exact level, but the 6mg claimed +/- is likely indicated. This is re-assuring, I’d been taking this for 15 months. Although, it too, most certainly had degradation. I had NOT been storing these capsules in a deep freezer. Vendor packaging advises to store at room temperature…
So I will proceed with the WHP, and with 4,000 mg, I have plenty to do more in depth trough/peak/side effects testing, although I need to prorate dosing for the less than 100% level.
For those sourcing raw powders overseas, you have to know the sample is most likely not 100% Rapamycin as starters, and may have other contaminants, unless you independently confirm otherwise. And critical for yield, keep in freezer any material prior to taking.
Even adding the $160 USD for independent lab test, and factoring in say 90% Rapamycin, my all-in cost ($220+$160)/(4000x0.9) = $0.105 USD/mg. About a tenth of what I was paying prior, and 80X less than prescription.
I will post any blood Sirolimus level experiments I conduct.