Rapamycin puts the brakes on a lot of things (inhibiting the mTOR pathway)… while you are taking it. When you stop taking it, things revert back to their normal processes… Male organ transplant patients have been taking rapamycin for decades. They have to lower their doses or take a break from it (shifting to other drugs) when they want to have children.
During spermatogenesis, spermatogonia undergo a few mitotic divisions and then differentiate into primary spermatocytes that undergo meiotic divisions to yield haploid spermatids, which differentiate to mature spermatozoa (Holstein et al. 2003, Cheng & Mruk 2012). Unsurprisingly, this process is highly controlled by a wide range of signaling pathways, including mTOR.
Sirolimus, also known as rapamycin, and its closely related rapamycin analog (rapalog) Everolimus inhibit “mammalian target of rapamycin complex 1” (mTORC1), whose activity is required for spermatogenesis.
Here, we test the hypothesis that rapalog inhibition of mTORC1 activity has a negative, but reversible, impact upon spermatogenesis.
Return to control values following a recovery period was variable for each of the measured parameters and was duration and dose dependent. Together, these data indicate rapalogs exerted a dose-dependent restriction on overall growth of juvenile and adult mice and negative impact upon spermatogenesis that were largely reversed; following treatment cessation, males from all treatment groups were able to sire offspring.
and another example in Transplant patients taking rapamycin:
Sirolimus was discontinued in all four male patients with full recovery of the oligo/azospermia and restoration of fertility.
Conclusions
This survey does not provide any warning signal that pregnancies fathered by male patients exposed to immunosuppressive agents, notably the debated MMF/MPA, have more complications than pregnancies in the general population.
Oh - and by the way. It would be great (though perhaps not possible) to get some good blood tests done before you start taking rapamycin. Its good to have a baseline so you can check to see the effect different dosing levels are having on your body. And it would be great if you enter our: A Friendly, Biological Age Reduction Competition?
See these two free biological age calculators. The measures in them (use the a.i. 3.0 version) are all you need in your blood test (but usually they give you a lot more info):
These two free methods of calculating biological age:
The Levine Phenotypic Age Calculator by Morgan Levine/Yale University
Good luck! Keep us updated on your journey! Here on rapanews.com you have a lots of knowledge and good quality mentoring. My plan is to start this year also. Where in the world do you live?
3 days after taking 1mg, no side effects. Feel good actually. but obviously still too early to tell. Will bump up to 4mg in 4 days.
I don’t expect to see any great improvements in terms of aging as I’m quiet young however I’m hoping the rapamycin will delay some of the aging as I get older. I’m starting early to prevent/slow aging, not reverse it. Only time will tell as I get older.
My pre-blood results are perfect. cholesterol perfect , LDL/HDL is in the ideal perfect range (better then good). which is expected given my age. My ferritin is abit on the low side which is normal as I have iron issues in the past. Taking an iron supplement once weekly. I’ll test my blood in 4 weeks from now to see if rapamycin has any negative effects against my blood work or positive effects, I’m particular curious to see if my cholesterol changes negatively as this is something i hear happens commonly with rapamycin.
Just got my rapamycin stock today, have enough until i hit 29 years old I think.
It cost like 20$ to get the script. Its also not a repeat script. 1 off script. The doctors on this site dont ask much questions about why you need the medication. I feel like they prescribe any drug as long as it isnt addictive/abusive. They just dont prescribe sleep tablets, Xanax etc.
When you order the script on this site you got to say you had the medication before. Click the “yes” I have used the medication before. If you say no. you may not get it. Sadly not many anti aging doctors who prescribe rapamycin in australia compared to USA. Keep in mind the cost is 5$ only if you have a medicare card a card that lowers prescript prices by ALOT (most aussies do) if you don’t the rapamune will cost around $1300. (private script), so if you’re in australia and get this script but you arent a citizen it will cost alot of money, rapamycin is expensive here just like in USA.
took my 2nd dose of 6mg yesterday, no side effects and still no canker sores! great news. I may increase my dose to 7mg if I continue to have no side effects.
