Just signed up! Thanks.
submitted a sample for this and received an email saying my results are ready, but system does not recognize my email!
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It would be nice to see the science behind yet another DNAm clock. Also, how does it compare to all of the other ones in terms of accuracy?
Looking at the subscription model, this is too much to pay for a program like that, especially since the endpoints are so vague (“longevity”), and the means to get there include a pill and a phone app. Most people would be better served spending that amount of money on a weight loss program like Calibrate, where at least the endpoint is reliably measurable (losing weight), and will contribute to healthspan anyway.
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A cheap way of measuring your biological age: get a device that measures pulse wave velocity for cardiac health. Consumer scales like Withings have that feature.
I wonder if these clock could be validated against the results of PWV readings. Intuitively, it does make sense that someone with poor cardiovascular health would have a faster biological clock, and vice versa.
Many of us use the Levine Phenotypic calculations, and Aging.ai , free spreadsheet based, and online… good enough given the current state of the science I think. See: A Friendly, Biological Age Reduction Competition?
You can run a large number of biomarkers against an age profile.
I just got the Tally Results back for my father:
This makes no sense to me as my father is one of the healthiest people I know.
He is:
1 . A pesco-vegetarian (some sugar sometimes)
2. Practices OMAD (1 meal a day IF)
3. A gym rat - does resistance training every other day
4. Is very healthy (great bloodwork)
5. Takes some supplements (vitamin D, glycine, NAC, Astaxanthin, Omega 3s)
6. Neither drinks nor smokes
7. Is on the light-side weight-wise (almost too light!)
I am not sure what could make him lead an even healthier lifestyle, but these epigenetic results seem plain wrong. However, when I did my own, my epigenetic age was 9 years older than my biological one. It may be some genetic factor that is skewing the results. Rapamycin did bring my epigenetic age down 7 years though from +16 years older for me!
However, based on a genomic analysis, we both have the FOXO longevity genes as well as other genomic predispositions towards longevity. Based on the aging.AI bloodwork, I am 19 years younger than my biological age. My father is similar.
Frankly, I’m baffled. And, with these kinds of results, either my family is an epigenetic aberration or there’s something wrong. Maybe our epigenetic ages are so good, they wrapped around the other side?
Maybe we should go for the longest living person record based on epigenetic age…
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Is there something in his past that might have negatively influenced his biological age? Smoking, diet, illness?
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He didn’t smoke. He did have a drink a day from his 20s to his late 40s and then gave it up. He had prostate cancer, but kept a close eye on it and had it surgically removed in 2019 with no recurrence. He had a normal American diet until he developed prostate cancer in the 2010s when he switched to vegetarian. Other than that, he has been in great shape and says he feels as fit as he did in his 20s. He, like @Agetron, is the paragon of health I wish I could be.
Now that I think about it though. Once a week back in the 1980s, our family volunteered at the church Bingo game for 3-4 hours each Friday. That place was so full of smoke, the second-hand smoke was probably as bad as smoking. I worked there too but that was in my childhood. Could that have done it?
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There is always the possibility that the test result is simply wrong
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If I were you I’d get his blood test results and see how he does on the Levine Phenotypic calculations, and the Aging.AI calculations for biological age. I wonder if they vary, or are consistent with the Tally Health measures…
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I am 41, and my tally age came back as 45. I’m a pretty healthy person, exercise, eat fairly clean, take rapa… i couldnt find any real information on how they generate their age. They try to get you to sign up for a membership to get any information.
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Was a beta tester for Tally Health too, just got my results back. Shows I’m nearly 10 years younger than chronological age.
Is anyone considering the monthly membership?
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Any idea how well your result compares to other tests… like the Levine Phenotypic calculation or the Aging.AI score?
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No idea, this was first foray into age testing.
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Eric Verdin, president and CEO of the Buck Institute for Research on Aging in Novato, California, is excited about the potential for biological aging tests—and his institute is one of several groups developing them. “They are great research tools,” he says. “But this is still early days for these tests. In my opinion, they’re not ready for prime time.” For one thing, he says, it’s not clear if all of the tests on the market have been validated by other scientists. Verdin also cautions that these tests haven’t been evaluated by the US Food and Drug Administration and aren’t regulated.
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Create a new account with the email address they used to tell you that your results are ready
I’m a little disappointed here because Dr Sinclair had been talking about how this new technique could find an epigenetic age for much cheaper and the tests would be $15 each. It appears they’re about the same price as other epigenetic tests and they’re pushing people into a subscription that includes a somewhat wacky “longevity supplement”.
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I think they realised if they charged 15 USD, they wouldn’t make a profit.
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