Hi and welcome to the site. We really don’t know what the best/optimal dosing for any age is… so its still a difficult decision for people at any age. There is a reasonable case to be made for starting earlier in life - as you are doing: The Case for Starting Rapamycin Earlier in Life (e.g. late 20s) vs middle age (e.g. 50s)
What we do know is that in the mouse studies that have been done so far, the earlier you start and the higher the dose, the longer the life extension. How well that translates to people is difficult to know.
You’re a pretty big guy. If I were you I would try 3mg for a while… e.g 6 to 12 months, and see how it goes. Do pre-testing bloodwork as we sort of outline in this thread: A Friendly Biological Age Reduction Competition?
See how you do with regard to side effects. If the side effect profile is acceptable at the lower dose, I might try dosing higher… with periodic blood testing as you go up to check for side effects that you may not notice directly (e.g. blood lipid levels, fasting blood glucose levels, etc.).
Your vacation period is a fine risk reduction strategy. Keeping mTORC2 activated is a good thing to think about, though I’m not sure with weekly dosing if we inhibit mTORC2 much. Some people do take
“rapamycin vacations” periodically, but I think most people don’t. Whatever you choose is fine, everyone has different risk/reward profiles.
There is no one approach that has good evidence … so we are all guesstimating right now the best approach. We’re all experimenting - so we try things, we measure results, and we try new things and we report back here on the results. I recommend you read as much as you can in this forum and learn from other people’s experiences.
Your supplement/drug stack seems reasonable and limited (which is a good thing). Many of us here are trying to keep the supplements and longevity drugs to the ones with the most study data and the most compelling evidence for them, with Rapamycin being perhaps the one with the most evidence of all for longevity improvement. As you add more supplements and drugs there is some risk of negative side effects - as outlined in this thread: Deeply disturbing information on combining longevity supplements
Let us know how it goes!