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How to Think About Longevity Interventions — By Looking for Where They Break
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5
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229
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March 10, 2026
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Anyone takes NAC? Plus maybe Glycine? Extends mouse lifespan by 24%. Glycine extends mouse lifespan by 5% in ITP study
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149
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6001
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March 10, 2026
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Oxygen, hypoxia and hyperoxia
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254
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18097
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March 10, 2026
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NAD+: nicotinamide mononucleotide or nicotinamide riboside?
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37
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3766
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March 9, 2026
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Some concerns around caloric restriction longevity studies in mice
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20
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536
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March 8, 2026
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Strategies to avoid the grim reaper of Cancer - Part I: Colon Cancer
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341
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25808
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March 8, 2026
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Anyone taking Selegiline / Deprenyl For Longevity?
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106
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14108
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March 6, 2026
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Interleukin-11 inhibition slows aging, results in 25% Lifespan Increase
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214
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19964
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March 5, 2026
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Is Dayvigo（lemborexant) a safe sleep pill?
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44
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3281
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March 4, 2026
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Targeting immune senescence and systemic aging
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6
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1709
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March 3, 2026
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This Year We Will Find Out If Reversing Aging Works In Humans - David Sinclair
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5
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558
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March 3, 2026
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Women Taking Rapamycin for Enhanced Fertility / Menopause Prevention?
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226
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51320
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March 2, 2026
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GLP-1 dosing for health benefits...not weight loss
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26
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936
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February 28, 2026
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Exploring Possible HGH Supplementation
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9
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1054
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February 27, 2026
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Any news from Dr. Harold Katcher's E5 compound?
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100
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11785
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February 27, 2026
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268% Median Lifespan Increase with Indolepropionamide aka Indole-3-propionamide or IPAM – What this is, and why more studies NEED to be funded!
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253
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15433
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February 26, 2026
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The curious case of Nebivolol - Lower Resting Heart Rate
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46
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9213
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February 25, 2026
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Sleep supplements: what is most effective, least habit forming, and safest?
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360
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25765
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February 23, 2026
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Glycine+NAC vs Rapamycin
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376
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39086
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February 20, 2026
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S-Mitochonic Acid 5. Increases ATP, NAD+ and SIRTUINS
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11
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1311
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February 17, 2026
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Strategies for mixing and cycling and dosing GLP-1s
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1
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244
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February 10, 2026
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Oral vs Topical Rapamycin for Skin Benefits?
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6
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1926
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February 7, 2026
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Why Aging Is Not Fundamentally Programmed — and Why Programming Still Matters
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20
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1029
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February 5, 2026
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Do you think we could live till 120-150yo by 2035?
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14
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747
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February 4, 2026
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Colchicine: Risky for Long-Term Brain Health?
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30
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2494
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February 3, 2026
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Anyone tried Astaxanthin large doses daily? Activates GSTA4 which is the same enzyme downstream from OSK partial reprogramming
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10
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740
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February 1, 2026
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Neutrophil Lymphocyte Ratio (NLR) - how to improve?
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34
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4070
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January 30, 2026
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David Sinclair (Life Biosciences) OSK human trials is now live. We will see OSK being injected into humans in 2026
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56
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3492
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January 19, 2026
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(IMPORTANT) SGLT inhibitors are not a substitute for Acarbose
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111
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12495
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January 18, 2026
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The interaction between DORA and RAPA
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3
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508
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January 9, 2026
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