Well, I just love being in an elite club, and all ….
Seriously though… in his video above he said he thinks it’s well over 10k in the US but under 100k,. She said something to the effect of 40x that in the world (this is going on my bad memory)
I’m suprised so few considering the podcast reach of attia/ferris etc? I mean, that is where I learned about it!!!
Considering half the people taking it are in this forum!, do we have a page where we share our dosing schedule? I know I’ve seen many comments but wasn’t sure if there was an organized spot that had consolidated the info… similar to a voting post? I have been told the average is about 6mg a week (by my doc), but thought I’d ask.
Also, after watching the video that once again mentioned canker sores, I want to be prepared because I’m a big baby. What does the hivemind say is the best treatment?
I am not taking daily lysine in the hopes it might help prevent this.
Different people have different views on dosing. I am on the extreme on the delay between doses (whilst also taking a relatively high dose taking into account acceleration).
Its really hard to set up a system to monitor this as it is at least a 3 dimensional question (dose, timing, acceleration)
I think you are right, I remember now Matt had Dr. An on the show and he discussed the dose titration for safety reasons and I think he settled on 6 mg/week.
So I guess, to contrast that, it would be great to learn from Matt about his theory why 1 mg per day was chosen for the Alzheimer’s study?
Does one need a steady trough level for blood brain barrier penetration or is there something about the Alzheimer’s diseases process that requires constitutional dosing?
BTW, Matt Kaeberlein is the one that wrote the editorial below, he is obviously very knowledgeable about the subject. Actually it would be great to have a whole episode about Alzheimer’s and rapamycin.
Thanks. His thoughts on the timeline for lasting benefit of rapamycin after stopping. He takes long breaks. Does he feel the benefits of rapa are faster and last longer than the related detriments of aging? So he can claw back 2-20x of aging in x amount of time of rapa dosing ? What benefit of any would a person hope to get by continuously taking Rapa (say weekly dosing)?
Archetypes:
If you are heathy but have an issue with inflammation in a joint, take Rapa for a couple months (until issue resolves), then start again when the issue returns.
If you have chronic inflammaging, stay with Rapa for longer periods. Only taking short breaks to let the body recover every so often.
If you want to take rapa “forever” just because…use a longer dosing cycle to let the body recover all along the way?
This is what I’m thinking about now. Any input from Dr Kaeberlein would be useful
I’ve had occasional canker sores my whole life, and Triamcinolone Acetonide Dental Paste USP, 0.1% is very effective. It’s a prescription paste. You put a glob on the lesion right before bed and it’s like 90% gone the next morning. Discovering it was actually life-changing, because I would get canker sores so bad I couldn’t eat solid food for days. Not anymore!
@beth I use methylene blue for this and other purposes. When i do get a canker sore I dab a little MB on it…it goes away <24 hours unless it was from me bitting the inside of my cheek (I hate that), then it takes a few days.
@John_Hemming So, what the cycle? What’s long enough for enough newly damaged mitochondria to accumulate to be replaced upon Rapa prompting? I suppose we are talking about autophagy and mitophagy…what’s your guess on how long does mTOR need to be turned down with rapa (or energy deprivation) to create a signal for autophagy / mitophagy, and then how long to let the cells components / mitochondria be replaced and then give time for more cellular proteins/mitochondria get old/damaged to need another hit? I understand mitochondria half-life is only 8-30 days. Since you do a 3 week cycle, is that your answer?
I would be careful here, don’t conflate aphthous stomatitis which can be auto-immune and respond well to topical steroids with ulcers induced by rapamycin which might be due to interruption of rapid cell division (via m-TOR inhibition) in the mucus membrane. Steroids can worsen the latter as it interferes with healing and repair.
There is uncertainty as to how frequently mitochondria replicate. There are figures between 2 and 350 days. Rapamycin is used to remove mitochondria so that mitochondria replicate and hence is intended to reduce the half life.
I use a number of interventions to increase mitophagy. The reason I set Rapamcyin at 21 days is because it has a relatively long half life. Hence it has a major effect for a few days and then the effect reduces gradually. Basically I don’t want it having an effect on my metabolism for more than half the time. I have for now set this as an accelerated 6mg every 3 weeks.
Thanks. I was surprised to learn just how short was the half-life of mitochondria (as they used to be bacteria I shouldn’t have been too surprised). For simplicity I think of the “replacement” process as two steps: (1) elimination and (2) rebuild and growth.
The elimination comes of damage (age of Mito, usage of Mito, availability of antioxidant protection) and shortage of energy and need for substrate. Time in life exposed to ROS, yeah OKRapa, fasting, endurance exercise, protein restriction
Rebuild and growth comes from refeed after rapa or fasting (energy & substrate shortage) and stimulus (endurance exercise for Mito).
So I’m thinking of timeframes for each….enough time for a need for mitophagy, then enough time to recover from increased mitophagy. Similar to you, I also want the rapa to clear out to zero before I get another hit. I use a 2 week cycle but take an extra week off every 5th week to be sure.
This is an interesting question, and perhaps others here have already researched it, but to what degree or level does rapamycin induce mitophagy? The boost in autophagy with rapamycin is well-known and document, but I’ve not come into much literature on rapamycin and mitophagy. Of course I haven’t looked much on this specific issue either.