Appreciate the links but nothing groundbreaking there. Just very generic advice on good diet, reduction of stress, good sleep etc. I already have all of those basics long covered.
No this isn’t some sort of allergy. It’s literally bacterial infections. I’m not sure how you could confuse those two things.
It’s pretty common sense that when it’s documented that a substance increases bacterial infections and I then have increased bacterial infections on the substance that it’s the substance that’s causing the increased bacterial infections.
I’m sorry that you were confused by the clearly stated facts and made a nonsensical statement and that my pointing of it out has offended you. By deleting your post you admitted guilt to said nonsense so I’m not going to feel bad.
Rapamycin probably reduces WBC count through the inhibition of the IL-2 response via mTor (that’s off the top of my head it may be some other cytokine). That is a bad news route to a reduction in WBC as it means infection can get a greater hold before being fought and in part it is fought moreso through the NF kappa B cytosolic ROS which is not a nice way of fighting things if it gets really big. (hence the cankers).
There are other reasons why WBC goes down which are arguably good reasons.
Bacterial infections are not commonly reported here in our forums, for users of rapamycin (and rapalogs… drugs that function in the same way as rapamycin). But, If you have a history of low WBC perhaps you are more predisposed that way and rapamycin further pushes you in that direction.
Here are the side effects that respondents from this forum reported in our survey - notice that bacterial infections were not increased… actually nobody reported an increase at all, I only included it on the list of possible side effects because I know people have concerns in that area):
Here are the side effects seen with the rapalog (a drug almost identical to rapamycin) Everolimus (RAD001, Novartis Afinitor) in the famous Mannick 2014 clinical trial (with elderly but healthy people, dosed weekly) where it was shown to improve aging immune systems in people. Dosing in this study ranged from 0.5 mg/week to 20mg/week.
An interesting question is what happens if someone takes both Berberine and Curcurmin one of which inhibits CYP3A4 and the other of which activates it (it appears to be metabolites of Curcurmin that do this).
I have been on Rapa 6 mg weekly for about 6 months and a blood test week ago showed a slight elevation in kidney function. Nothing to write home about but was up 6 points.
I had a bacterial infection while taking Rapamycin a few weeks ago. I had to stop the Rapamycin and take antibiotics. After the infection cleared up, I started the Rapamycin again… Along with a good probiotic.
The Daiwa Health Development site says that their BRM4 product "has been shown in clinical studies to enhance the immune system by increasing the activity of the white blood cells.* Scientific research indicates that the active ingredient in BRM4 ® can enhance Natural Killer (NK) cell function, increase the count of T and B lymphocytes, strengthen and increase the macrophages and cytokines.”
The preceding quote is from BRM4 ® 500mg | Daiwa Health Development, Inc.
I don’t have personal experience with it, but it sounds harmless at worst…derived from rice bran modified by an enzyme from shiitake mushrooms. The site continues “shown to be safe with no harmful side effects.”
Hello all!
I think I’m also with more bacterial infections with rapa being the cause.
In my case, I started cycles of rapa 1mg 2mg, 4mg , 6mg, 7mg. So I’m in the 5th cycle.
Between 3rd and 4th, I started cough, with bacteria in the phlegm (that I didn’t have for years… I’m in excellent health, no smoker, excellent diet…). My body healed completely, and 16 days after last rapa, I took another rapa dose (6mg), again it returned stronger, my cough appears as a long time smoker. I thought maybe coincidence, maybe body fighting something that was overthere from the past… I healed completely, no rush, 22 days after last rapa, I took another rapa dose (7mg), and 24 hours after, Cough with bacteria on phlegm. So not believing in coincidence, and not normal in my health this bacteria infections. Pretty sure it is the rapa.
So cough and bacteria, are my side effects for rapa.
during this last months, that I started rapa, I also started metaformin. I discovered, that maximum for me is 500mg. And atm I’m using just when getting a high carb meal.)
In my body feeling the 1g/day of metaformin, 500mg, in the two main meals, for me, sure was excessive, and I can not describe well but I was not feeling well.
If you are getting a bacterial infection every time you take Rapamycin, I’d do a thorough study of your environment to determine where this bacteria is coming from and eliminate the source. Rapamycin does not come with bacteria!
I can report my experience. I had a lot of strep throat infections when I was a child and as a result my tonsils were enlarged, swollen and whenever my immunity dropped I would get an infection (from endogenous bacteria populating my inflamed tonsils). Last years these infections were with abscesses forming in my throat, which is rather painful condition if you can imagine. Since starting rapamycin (6mg/week/7 months) I had no infection and my tonsils decreased in size are much less swollen and inflamed. I am scheduled for a surgery in January to remove them, but since my experience with rapamycin I am thinking to postpone my final decision.
DId you have any bloodwork done, tested for bacterial infection?
Hello all ,thanks for the support. @John_Hemming my CRP last time tested, 0.03 mg/dL (60 days ago,in this test, below 0.1mg/dl is low risk of cardio disease) @RapAdmin thanks for the suggestion of the probably 4mg of optimal dose. I was trying to get higher rapa to enter the “brain barrier”, but probably will stay lower for more time, and will see the possibility of raising in the future… @DeStrider nice point lol, yes, rapa doesnt come with bacteria, and there is logic on this.
The thing is, before rapa, no problems with bacterias, during rapa cough with bacterias.
I use clean clothes, regular change in bed sheets, hepa filters in office and bedroom(too much I know), good overall enviroment. and travels not happened, in last 90 days, but I travel, sometimes by bus during night, airplanes, where I sleep with strange people side by side… and no problem with bacteria and cough. So now, is something about rapa that is messing with this bacteria/cough.
Anyway, I dont know if I can identify with @scta123 enlarged tonsils. but I lived in a city until 7 years ago, that I suffered badly of allergic rhinitis. (Curitiba, the city is champion on giving allergic rhinitis to their population.) But when I moved from there, I thought I was cured, and I don’t know of any sequelae that would have remained in my body. Like the enlarged tonsils described. but yes there is this possibility, I will check and report on this in the future. (but appears to me that the infection of this coughs are more on the lungs, not in the mouth/tonsils). The message that I understood that you sent, (and I think is a possibility) is that maybe there is something in my body, that my body is fighting right now, but can be better in some months, and rapa can help on this? @scta123 ? optimistic view of the situation of course.
