Yes, there is a lot of evidence that SGLT2 inhibitors (e.g. Canagliflozin) are one of the stronger anti-aging drugs. Every time new research comes out on these drugs (good or bad) I add it to the thread on this topic:
[CanagSm3]
National Institutes on Aging , ITP study
Canagliflozin extends life span in genetically heterogeneous male but not female mice
Increased median lifespan in the male mice by 14%, maximum extension of 9%
But had no effect on the females
Canagliflozin is in the class of drugs known as SGLT2 inhibitors. SGLT2 inhibitors have been commercially available for over 10 years and they are used commonly in patients with type 2 diabetes as it blocks the re-uptake of glucose so that more glucose is excreted in the urine. They affect the process in the kidney that deals with very high glucose levels without having much scope for causing toxicity, so are safe from causing hypoglycemia.
While canagliflozin…
3 Likes