A related discussion:
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That’s a great point!
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This makes me debate using metformin, since it would seem to blunt some of the positive benefits from exercise such as VO2 improvements and some other relevant adaptions (but not all) 
From what I gather, it’s entirely plausible that metformin’s life extension potential may only be due to observations of diseased participants (who are less likely to exercise).
Yes - I was on metformin a few years ago, and continued it initially when I started rapamycin. But I stopped when the news started coming out about the impact on muscle, as I mention here: Rapamycin + Metformin
But I’ve become a little less dogmatic on this… you might try with and without for 4 months and see if you notice a difference. Bryan Johnson takes Rapamycin, Metformin and Acarbose and doesn’t seem to be suffering too much on the muscle /strength side of things: Brian Johnson's Longevity Protocol - Your Thoughts?
And, if you look at our poll/survey of our rapamycin users - the most common other medication people are using is metformin: Rapamycin User Survey #2 - Please Respond
So, like most things, its complex 
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I’m a huge fan of Joyner. Followed him for years and years and really enjoyed this interview.
One of the big reasons I was interested in rapamycin is because after hearing and reading about its effects it sounded a lot like some of the adaptations/effects you get from running. It especially reminded me of fasted state long runs, where you fast for 12-14 hrs then do a long run with no nutrition.
I can’t help but view rapamycin through the lens of a coach/trainer and the adaptations it brings to the table. I’ve always exercised knowing/hoping that it will help with longevity. Hopefully adding rapa to the equation will help with compression of morbidity.
To that point, does anyone else view taking a weekly dosage of rapamycin as a stimulus towards adaptation? Similar to that of a workout? Incorporating it into my running routine reminds me of how I feel after a fasted state run. My legs are more tired and I feel a bit more beat up as if my muscles weren’t using readily available glycogen stores for the workout.
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I love this graph in principle, But I’m not convinced by the functional correlates to vo2 max.
This paper suggests 20+ is needed to climb 5 flights of stairs. And only 12+ for one flight of stairs.
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anyone looking to increase their exercise?
‘Some species of gut-dwelling bacteria activate nerves in the gut to promote the desire to exercise’
https://www.pennmedicine.org/news/news-releases/2022/december/gut-microbes-can-boost-the-motivation-to-exercise
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Sounds good, but are there any supplements available to directly increase Eubacterium rectale and Coprococcus eutactus other than fiber, fermented foods, etc.?
Some species of gut-dwelling bacteria activate nerves in the gut to promote the desire to exercise’
OMG…I need that… lol.
I exercise religiously every other day - going in a few minutes…arghh.
Hate it… but do it!
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They don’t do a very good job of defining vigorous exercise vs. very vigorous exercise. And that’s the difference between heart disease and no heart disease. One is good, the other is bad. Fairly important.
I run zone 2, heart rate around 130 for 2 miles. Lift weights for another 10 minutes. Is that vigorous for very vigorous for a 62 yr old man?
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What is the single best strength-building exercise many of us could be doing right this minute but almost certainly are not? Consult enough exercise scientists and the latest exercise research, and the answer would likely be a resounding: squats.
“For lower-body strength and flexibility, there is probably no better exercise,” said Bryan Christensen, a professor of biomechanics at North Dakota State University in Fargo, who studies resistance exercise.
The benefits are not confined to the lower body. “It is really a whole body exercise,” said Silvio Rene Lorenzetti, the director of the Performance Sports division of the Swiss Federal Institute of Sport in Magglingen. “It requires core stability and trains the back.”
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I like this idea of using this to track my fitness:
Epigenetic Biomarker for Measuring Aging Through Fitness
This biomarker is a useful addition to GrimAge.
Research Paper:
Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. We develop blood-based DNAm biomarkers for fitness parameters gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest correlation with fitness parameters in five large-scale validation datasets (average r between 0.16–0.48). We then use these DNAm fitness parameter biomarkers with DNAmGrimAge, a DNAm mortality risk estimate, to construct DNAmFitAge, a new biological age indicator that incorporates physical fitness. DNAmFitAge is associated with low-intermediate physical activity levels across validation datasets (p = 6.4E-13), and younger/fitter DNAmFitAge corresponds to stronger DNAm fitness parameters in both males and females. DNAmFitAge is lower (p = 0.046) and DNAmVO2max is higher (p = 0.023) in male body builders compared to controls. Physically fit people have a younger DNAmFitAge and experience better age-related outcomes: lower mortality risk (p = 7.2E-51), coronary heart disease risk (p = 2.6E-8), and increased disease-free status (p = 1.1E-7). These new DNAm biomarkers provide researchers a new method to incorporate physical fitness into epigenetic clocks.
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