How to buy Rapamycin (Sirolimus)? What is the cost?

Following is a description of the best and most common ways to buy rapamycin for anti-aging (We really recommend working with a doctor since anti-aging is a new application for this drug):

  1. Get a doctor’s prescription and purchase with a prescription. This is done by contacting one of the doctors who is prescribing rapamycin for aging. See our list of doctors prescribing rapamycin for aging.
  2. Note that Rapamycin for aging typically won’t be covered by insurance / healthcare programs (yet) so you’ll need to plan to pay for it yourself.
  3. When people can’t find a doctor in their area / country that will prescribe rapamycin, they are purchasing directly from online pharmacies that sell rapamycin without need for a prescription. This is also something people do to save money on their rapamycin (buying from international sources). See detailed descriptions on this process in the “Importing Rapamycin” post, and our list of “Reliable Online Pharmacies” that people have reported good results with.
  4. For people in Europe, another option is to purchase rapamycin in Turkey. It is inexpensive and we understand you do not need a prescription in Turkey for rapamycin (Rapamune / Sirolimus). People are buying in Turkey when they are on vacation there, buying from a few resellers via online services, or having friends who live or visit there and who mail or bring them the rapamycin. See this discussion - No Prescription Needed for Rapamycin Purchase in Turkey.
  5. Getting Rapamycin: Once you have a prescription, you can purchase either the brand name drug (Pfizer Rapamune) or the generic sirolimus. Brand name pricing is 300% to 500% higher than the generic medication. But, there seem to be increasing evidence that generic medications (broadly speaking) are a little bit riskier than the brand name products. See our article about testing your medications.
  6. In the USA, you can use GoodRx coupon / service and you’ll pay around $3/mg to $6/mg for the generic rapamycin (or around $160 to $220 for a month’s supply.
  7. Pricing Examples from GoodRx: GoodRx Rapamycin/Sirolimus Current Pricing
  8. See Amazon Pharmacy Pricing for Rapamycin / Sirolimus (Generic)/ Rapamune (Pfizer Brand) - note, there seem to be good prices for Prime members, 90 day supply - $383 for 90 tablets ($4.25/1mg tablet) last time I checked:
    Sirolimus
    Rapamune

Medicine Pricing - USA vs. Rest of World

Because rapamycin for anti-aging is not covered by insurance, the cost is entirely paid by the user of the drug. And, if we follow the example of the studies done in mice, to gain the maximum lifespan benefits of rapamycin it seems that we may need to take it for the rest of our lives, so the cost per year will add up greatly over time.

As it is today, the US has the highest drug prices in the world due to the combined effects of lack of competition and limited regulation. A recent study revealed that U.S. prices were 218 percent higher than prices in Canada (or, alternatively, Canadian prices were 46 percent of U.S. prices). U.S. prices were 256 percent of those in the 32 OECD comparison countries combined. In comparisons with individual countries, U.S. prices ranged from 170 percent of prices in Mexico to 779 percent of prices in Turkey. Among comparisons with individual G7 countries, U.S. prices ranged from 209 percent of prices in Japan to 258 percent of prices in France.

Because of this we see increasing number of people who are looking towards other countries - from Canada and Mexico, to more distant places like India - to fill their prescriptions because the medications there are frequently a fraction of the cost that they would be in the USA.

The cost savings you can see when buying from foreign suppliers of medicine is as true for rapamycin (sirolimus) as it is for any other medications.

Pfizer Rapamune and Generic Sirolimus

In the USA the first and main brand of rapamycin is Pfizer’s Rapamune. The generic name for rapamycin is “sirolimus”. If you are thinking of buying some rapamycin be sure to read this article about all the different names for rapamycin. You may get rapamune if you have a prescription in the USA or you may choose the generic sirolimus due to its lower cost.

Rapamycin Cost / Pricing Summary

For example, the typical cost comparison for Rapamycin / Sirolimus looks something like this:

Rapamycin USA Prices:

Pfizer Rapamune Brand Name Product:

Pfizer Rapamune Average Street Price: $1300 for 30 x 1 mg tablets ($43 per 1 mg tablet)
GoodRx Discounted Pfizer Rapamune Price: $950 for 30 x 1 mg tablets ($31.60 per 1 mg tablet)

Rapamycin Generic Sirolimus:

Generic Sirolimus Typical Street Price: $480 for 30 x 1 mg tablets ($16 per 1 mg tablet)
GoodRx Discounted Generic Sirolimus Price: $110 for 30 x 1mg tablets ($3.6 per 1 mg tablet)

Rapamycin India Prices:

Approximate India Sirolimus Pricing:

Zydus Siromus (Sirolimus) Price High: 1000 rupees for 6 tablets of 1 mg ($2 per 1 mg tablet
Zydus Siromus (Sirolimus) Price Low: 500 rupees for 6 tablets of 1 mg ($1 per 1 mg tablet)

Note: The India internet pharmacies have generally been amazingly good as far as delivering the medicines they promise. We’ve spoken to a many people who have ordered their medicines from India Pharmacies and everyone have had good experiences and always have received the medicine that they ordered. The only exceptions we are aware of being that a couple of times people’s orders have been held up or blocked at US customs.

Rapamycin Yearly Cost Estimates:

Most people taking rapamycin for anti-aging purposes report taking somewhere between 5mg per week and 10mg per week (all in a single dose per week). As you can see, there is a significant savings. If you’re taking rapamycin for life extension at the 5mg dose, once per week level, you’ll need about 260 of the 1mg tablets a year, and if you’re at the 10mg per week level you’ll need about 520 of the 1mg tablets per year.

The cost at the USA high end for 520 tablets, Rapamune brand, is $22,000+
The cost at the USA mid-range for 520 tablets, Sirolimus Generic, is $8,300+
The cost at the USA mid-range for 520 tablets, GoodRx Sirolimus Generic, is $1,800+
The cost at the India Low end for 520 tablets, Zydus Siromus, is around $520

We have heard from users in India who have had this to say:

“I live in India so getting it is no problem you just go up to the counter and ask for it. As for the cost it costs 6 dollars for 10 * 1mg tablets” (so, approximate cost of $312 for a year’s supply of 520 1mg tablets)"

Note: Some people are getting even lower prices by purchasing raw sirolimus powder (CAS ID 53123-88-9) from either laboratory reagent suppliers in the US (you need to work in a lab or biology or chemistry department of a university typically to get access to these, or know someone who does), or purchasing the raw sirolimus powder from vendors in China. We really discourage the later of these options as you have no legal recourse if the product is contaminated, you don’t know the quality (and its our belief that testing of any raw product from China is absolutely a requirement).

If you are looking at using cheaper medications from outside the USA, please review our section on testing your medications for purity, dosing and common contaminants.

And, for information on the cheapest approach to buying rapamycin, read this story: Importing Rapamycin - People’s Experiences.

Also related: List of Reliable Online Pharmacies for Buying Rapamycin, etc

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I buy my Sirolimus from Tailor Made Compounding

30@3mg capsules. Cost, including shipping, was $102.

Prescription needed

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Looks like a good company:

I’ve ordered Sirolimus and Dasatinib from them. Quality company, IMHO

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I’m from EU and they are very strict about Rapamycin, so I think is the best way to order from India. Guys Can some one send me PM trustworthy / reliable source where I could buy it. Or if you got Rapamycin from USA to send me private. We need to help each other :slight_smile:

Thank you.

Another option is to use Everolimus from Indian sources as 10mg doses are much easier to obtain. From my reading Everolimus seems to dose 1:1 with Rapamycin.
I’ve just received my first 10mg x10 box manufactured by Glenmark which was $60 +ship. I have no purity data though, so I’m reluctant to call it a perfect option.

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I think this covers it: I’ve not heard of a single vendor on Indiamart.com not coming through with the product that was promised.

Best approach is to just search for the best price on a specific version of sirolimus you are interested in.

See Valisure test results on some batches of rapamycin purchased from India at bottom of this page;

I found one store http://rapamycin.store, does anyone have any experience with them?

No experience with them, there are literally hundreds or thousands of internet pharmacies that sell rapamycin, so they are no different than others in that respect I guess. Well - as I look at that website it seems that its even worse than most internet pharmacies because they don’t sell brand name pharmaceuticals, they sell something that they either repackage from another company - but you don’t know who, or they manufacture it themselves, which is also scary… since they likely don’t have the volume necessary to invest in the quality control processes that a typical drug company would have.

You can look up any online site’s reputation on the ScamAdvisor website:
https://www.scamadviser.com

I’m not sure how good this scam advisor site is… but its a start.

People ask me all the time - what are some good internet pharmacies to buy rapamycin from - but I really don’t think it matters. Almost everyone I’ve taken to who has ordered product from Indian pharmacies have all gotten what they paid for - (I’ve heard of one person only in the past year who didn’t get what he ordered and paid for) pretty amazing really - I thought it would be much worse). So it seems that these guys are in business for the longer term and not just out to scam you for a single order’s cash. From most people’s experiences here (I talk to a lot of people about this) its not much different from interacting with your corner pharmacy like Walgreens - but you pay by wire transfer and its mail order (and it all comes in a brown paper box wrapped in tape like a present your mother sends you at xmas).

The bigger issue… The key thing you need to focus on is the proven quality of the actual rapamycin products, the companies/brands producing the rapamycin. Ideally you want to see lab tests from high quality third party labs to validate the purity, the dosage and to check for common contaminants.

It would be really nice if more people shared their lab tests on all the different rapamycin products from the major brands/ producers/pharma companies.

We have some Valisure test results on rapamycin batches from Biocon and Zydus here from a year or two ago. This is just one lab analysis - so its a start, but ideally we all really want to be having all our rapamycin lab tested so we know we’re getting quality products. This goes for all generic medications - becaue there are issues in this manufacturing system and lack of FDA oversight - but check this page - and see the lab test at the bottom of the page to start with.

And - please, if you get lab tests done - share them here…

and see this page:

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Don’t know if this belongs here but I was surprised to find that the new online Amazon pharmacy has a very good deal on generic sirolimus. For prime members, 90 2mg tabs is $307. The best I could find on goodrx was $660.

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That absolutely belongs here. Thanks for posting!

That is awesome. At about $1.70 per mg from a domestic pharmacy delivered, that compares well with the lowest cost foreign sources, assuming you have a prescription.

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Pfizer’s Rapamune here in the Belgium Pharmacies is 361,6 euro for 100 x 1mg. I even get it refunded by my health insurance :star_struck:

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@Ludovic , I see many people in the EU complaining about the difficulty in finding doctors, and pharmacy sources for rapamycin. How did you manage to get both if I may ask? And you got it covered by insurance… fantastic. Please share how you managed to do this, I’m sure many European visitors would like to know more.

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Sorry for the late reply, I think it’s all about finding an open minded doctor and then building a relationship of trust with your doctor by being honest and open. It helps that I have a medical background ( I use to work in a medical lab) and I get blood work done every 2 months, so he trusts that what I am using has no negative effect on my health markers. I work for a multinational with the best private health insurance, so I get all doctor prescribed registered medication reimbursed, I only have to pay the government taxes.

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https://www.inhousepharmacy.vu/

this Pacific island nation sells Rapamune, no prescription required, accepts E-check payment, shipped by airmail. Buy at your own risk.

Did you try them? Were you happy with the results (the product they shipped)? What country did they ship to (I’m particularly curious about countries other than the USA - as it seems some people in other countries sometimes have more problems getting medicines).

No, i will try them and report later.
i just got it from a Twitter post. Their website seems legit.

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Hmmm… not a great score on scam advisor. I’d go with a higher ranked site in India before I’d go with these guys:

https://www.scamadviser.com/check-website/inhousepharmacy.vu

That’s strange – I’ve ordered many times from inhousepharmacy over a period of 5+ years and have always received my orders in a timely manner without any problems.

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