I (m/47) just took my first dose today (2mg) and after that experience I would say to start low and build up gradually from there.
To be honest I probably wouldn’t take rapamycin at your age just yet, I’m probably taking it too young even, in mice that get rapamycin from about the equivalent of 65 years benefit as much as mice that get it from the equivalent of 18 years old
Hi, and welcome to the forum. I think the general theory that is popular in the (small) Rapamycin-oriented medical community is that lower doses are better when you are younger. Higher doses when you’re older (up to a point) - after a certain age, depending upon your physical condition - the older you are the harder it is to dose rapamycin because of complications of polypharmacy (taking many different medications, and the issue of potential conflicts/counterindications in the drugs).
In the last video conference call with Matt Kaeberlein, Dr. Green and Blagosklonny a week or so ago, I heard that Dr. Green, who is now 79 years old, is taking two days of 12 mg of rapamycin every 12 days or so. Not that we have a lot of data on this in humans, but given the state of the human clinical trials (minimal), from a risk/reward perspective it is reasonable to not risk high doses of rapamycin at an early age. In a few years we’ll have a lot better data, and at 35 you aren’t losing a ton of function due to aging during that period.
So - read up, please do full blood work and calculate your biological age before, and then again after you’ve been taking rapamycin and post here in the forum.
@mcormier Welcome to the community, fellow Canuck (Toronto). Since you’re into software, this is THE perfect place for you. You cannot change your genes (hardware), but everything else you do will impact your epigenetics (software) and lifelong health trajectory. Go at it!
I’ve been a patient of Dr Green for about 3 years. I would go with his recommendation for dosage. Actually since it’s a prescription drug you really won’t have a choice unless you can get another prescription or buy some from India which I don’t necessarily recommend.
Of the three, Matt, Dr B, and Dr Green, Dr Green is the one with the clinical experience with hundreds of patients. I know him both as my doctor and as a friend and I trust his judgment. He’s one of the best analyzers of research papers that I ever worked with.
I’m 70 years old, and I’ve been taking 6 mg a week for 3 years and have seen significant positive results from that dosage. More is not necessarily better. I’m not saying it’s worse, but No one really knows the optimal dose. It’s all pretty much guesswork at this point.
I will try to find the reference, but while rapamycin seems to have good effects even in older organisms, protecting blood stem cells only seemed to work when started in young organisms. So there is some benefit in starting earlier rather than later.
Hi @jakexb welcome to the site and thanks for participating. yes - rapamycin seems to slow down aging of blood stem cells but not reverse the aging. This is true in many situations - e.g. hearing, etc.
So there is a good case to be made that taking rapamycin sooner rather than later is a good idea.