Has anyone had experience with taking rapamycin in relation to Parkinson’s?
I was diagnosed with Parkinson’s in December 2020 & confirmed again by Datscan in January 2021.
I do not take any medication but use alternative healing methods successfully.
see www.parkinsonclub.de
I have been taking 5mg of Rapamycin every week now since the end of March 2023. I have not noticed any changes in my Parkinson’s disease so far. However, my health condition is very stable. I was diagnosed with Parkinson’s in December 2020. I do not take any medication until today. www.parkinsonclub.de
Sorry to hear about the diagnosis. If the same happened to me, compounds I would look into (in addition to rapamycin) include melatonin, carnosine, astaxanthin (all OTC compounds in the US) which exert antioxidant effects in the brain.
Melatonin looks promising and has decades of research: Review 2005
More recent Review 2021
“In studies on animal models of PD melatonin was effective to curtail symptomatology in doses that allometrically projected to humans were in the 40–100 mg/day range”
They asked 1,084 Parkinson’s patients which supplements they took and followed the progression of their symptoms. It’s purely self-reported and prone to a lot of confounders, but the conclusion is: “Nutraceuticals associated with improved outcomes were Ginkgo biloba (GB), NAD+ or its precursors, 5-methyltetrahydrofolate, glutathione, mucuna, CoQ10, low dose lithium, curcumin, homocysteine factors, DHEA, coconut oil, vitamin C, and omega-3 fatty acids (fish oil).”
Taurine, astaxanthin, and sulforaphane were not part of the survey (or maybe not used by the participants), but they may be worth exploring:
Hello Lin,
thank you very much for the information.
I have also planned to take melatonin.
However, at the moment I am trying out other therapies and still need time for this. My condition is very stable with slight improvements. Therefore, I do not have very much pressure.
Many, many thanks for your help!
Hello adssx,
thank you very much for the information.
I have already planned to take Ambroxol.
I also have Ambroxol at home. However, I am still waiting to see what the study results will bring.
However, at the moment I am trying out other therapies and still need time for this. My condition is very stable with slight improvements.
Therefore, I do not have very much pressure.
Many, many thanks for your help!
Selegiline is a Parkinson’s drug at 10 mg/d (swallowed, equivalent to 1.25mg in oral dissolving tablets) but at low-dose (1mg/day swallowed) it may have life extension properties and may prevent or slow down Parkinson’s. It’s still unclear whether selegiline and rasagiline have disease-modifying properties for Parkinson’s because trials showed an inverted U shape relationship: low rasagiline doses seemed to slow down the progression while high doses did not. The FDA considered that the absence of a dose dependent relationship proved that it wasn’t a DMT but you would argue the opposite: it’s consistent with trials of selegiline on mice that showed an inverted U shape as well: no impact on longevity for super low doses, positive impact for low/medium doses and negative impact for high doses.
“Contrary to the widely held belief that Parkinson’s disease originates from the degeneration of dopaminergic neurons, a new study suggests a precursor: synaptic dysfunction. […] Based on these findings, we hypothesize that targeting dysfunctional synapses before the neurons are degenerated may represent a better therapeutic strategy.”
If you ask ChatGPT how to enhance synaptic activity, you’ll get the usual suspects: Omega3, antioxidants, exercise, meditation, learning new things, reading and problem-solving, vitamins B and D, and cognitive behavioral therapy. But also nootropics, antidepressants, neurofeedback, deep brain stimulation (DBS), and transcranial magnetic stimulation (TMS).
Altitude is HYPObaric, so people assume that the reason is because of the hypoxic environment, which could activate autophagy (same as intense exercise?).
If true, the extreme option would be to move to a place in altitude (another positive point: less pollution), but I wonder if regular trips to the mountain for holidays can also have a positive impact.
The interplay between autophagy and ROS is very complex. I
" 5. Conclusion and Perspective
Plenty of studies have repeatedly shown that ROS accumulation displays detrimental implications for the basic function and survival of neurons. ROS or oxidative stress can provoke autophagy, and autophagy can take part in the removal and repair of ROS-induced oxidative lesions through a variety of signaling pathways. But autophagic neuronal death will still result if cumulative ROS go beyond the scavenging activity of autophagy. At present, it appears to be contradictory that autophagy serves as a cellular self-purification mechanism, but hyperactivity or hypoactivity of autophagy is unfavorable for the normal functionality of neurons [162, 163]. After all, the predetermined threshold level of perfect autophagy is often blurred, particularly under a variety of disease courses"