Week 6 Update.
I’ve done 6 doses of Rapamycin, and I’ve added in some Acarbose alternating with Canagliflozin to my stack. I had some new blood tests done, here’s what I’m seeing.
eGFR has gone from 86 to 73, so definitely a drop there, and creatinine has gone from 1.09 to 1.25. Anecdotally I’ve heard other people mention that the drop in eGFR happens to them from rapamycin so maybe this isn’t completely unexpected. I will order a cystatin C test next time around.
My CO2 blood levels have gone from 29 to 18, which was flagged as low. I’m assuming this is a side of acarbose/canagliflozin and I might dropping into ketoacidosis at times, would that explain it? The uranalysis was also flagged for high glucose, no doubt a side effect of canagliflozin.
My liver enzymes had some interesting changes. If you recall, my AST levels were elevated at 46 pre-rapa, now they are at 21, a huge drop which I’m happy about. ALT also moved from 15 to 9. Pretty significant changes imo. Oddly enough Alkaline Phosphatase went up from 78-102. I’m not exactly sure what’s happening here but my liver enzymes have changed markedly.
On the cardiovascular side my LDL was virtually the same at 126, while ApoB dropped from 92 to 86. I have to admit I thought I would see a more dramatic drop in LDL and ApoB since I’ve been going hard on the psyllium husk, amla, and astaxanthin. My triglycerides went from 61 to 78, a pretty big move up, I’m assuming from the rapa. I will likely add ezetimibe and lithium to my stack to help in this area. I have a CAC scheduled for March 3rd.
Hba1c went from 5.1 to 5.3. I’m a little surprised at this since I’ve been using acarbose and canagliflozin. I’ve never had a reading above 5.1 before.
In general I feel great. I’m sleeping better than I have in years (although not necessarily on the day I take rapa). One odd side effect I had several times was a pain which I thought was in my right lung. I went in to see the doctor, he performed a chest x-ray and the only thing it showed was the scar tissue in both lungs from covid-pneumonia which I had in 2021. The doc figured it must be musculoskeletal and prescribed ibuprofen and a muscle relaxant. I only took the ibuprofen for a few days and then it seemed better but it’s something to monitor.
I’ll probably rearrange the supplements I’m taking going forward. I don’t love the acarbose, I much prefer Canagliflozin and I’ve dropped a few pounds on it as well.
Those were the highlights from what I see. Let me know what you guys think!