We had a post a few days ago about the need to have a list of compelling research that people can direct/email their doctors to, so that their doctors can get a better understanding of the scientific and medical facts behind the interest in using rapamycin as a drug for treating aging.
The goal in this wiki is to provide on a single page the best, most compelling research and clinical information to help the traditional medical doctors learn, support (patients taking rapamycin) and hopefully adopt rapamycin in their practices.
Anyone can edit this wiki - but please, just add papers and relevant links, don’t delete other people’s contributions.
Rapamycin is considered by many geroscience researchers to be the “gold standard” of anti-aging drugs; the lifespan improvement seen in animal trials are consistently the best of any drug (15% to 30%). It increases healthspan and lifespan in every organism its been tested in - from yeast, to flies to worms to mice (over a billion years of evolution). Its the compound with the most reproducible life extension effect, having been tested and retested by many different labs around the world in a wide variety of different species of organisms and animals. And, rapamycin is an FDA-approved drug that has been in use for over 20 years, by millions of people (in cancer and organ transplant treatment regimens).
- What are the Rapamycin Clinical Studies that Have Been Done in Healthy Humans? (vs. organ transplant patients, cancer patients, etc.)
Publications by Blagosklonny:
- Are Anti-aging Drugs the Key to Cancer Prevention?
- Koschei the immortal and anti-aging drugs
- Rapamycin for longevity: opinion article
- Fasting and rapamycin: diabetes versus benevolent glucose intolerance
- Rapamycin and quasi-programmed aging: Four years later
- Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
- Disease or not, aging is easily treatable
- The hyperfunction theory of aging: three common misconceptions