if u are taking rapa, u might as well add nacgly to it and may you live 50% longer than the median 
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I have been taking NAC, with and without glycine, for eight years. The basis is primarily theoretical. I cannot discern subjective effect on my feeling, energy, etc. beyond what might be improved lung function. I’m not in the megadose camp however and limit my dose to no more than 2,400 mg NAC and 3,000 mg glycine. I cycle the administration 5/2. Lately, I have reduced the amount of glycine I pair with NAC upon discovering I am homozygous BHMT 08 (rs651852(A,A)). I have not yet worked out an evidence-based resolution of the issues.
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I dont think we are supposed to feel anything.
Gluthatione is just our master antioxidant and healthy levels of it reduces ROS. So there is nothing to feel.
Maybe just a sense of general wellness.
The key is just to take it daily.
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We can probably say the same for 99% of supplements
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it is an interesting question, isn’t it. I was having this discussion the other day. Based on occasional times when I take no supplements for from 1-3 days, I pretty sure I can detect a subtle difference in my level of energy across the full waking hours but it is not dramatic. Most recently, I added a supplement – Urolithin-A – for which the effects on my muscle performance has been unmistakable. I would have to think about it more but UA might be the only exception.
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Hi,
Can you guys tell me if taking TMG will have the same effect as Glycine? (Taken with or without NAC).
Thanks
Shez
TMG is basically glycine with some methyl groups so it should, in theory, have the same effect. Maybe even better because it provides your body with much needed methyl groups.
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I have asked four different Ai, they all said no, TMG cannnot replace Glycine.
“The short answer is no, taking TMG with NAC will not have the same effect as taking Glycine with NAC (GlyNAC). While they share some overlapping territory, they are fundamentally different combinations with distinct primary purposes”
“For the specific, well-researched effects of GlyNAC (glutathione boosting, oxidative stress reduction), you must take glycine with NAC. TMG is not a substitute for glycine in this context.
· TMG with NAC is a different combo aimed at methylation and homocysteine metabolism. It’s useful but for different reasons.”
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TMG donates it’s three methyl groups to the body and eventually turns into glycine. By that process (TMG → DMG → Monomethylgylcine → Glycine) you get roughly 3 grams of glycine for every 10 grams of TMG you take.