if u are taking rapa, u might as well add nacgly to it and may you live 50% longer than the median 
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I have been taking NAC, with and without glycine, for eight years. The basis is primarily theoretical. I cannot discern subjective effect on my feeling, energy, etc. beyond what might be improved lung function. I’m not in the megadose camp however and limit my dose to no more than 2,400 mg NAC and 3,000 mg glycine. I cycle the administration 5/2. Lately, I have reduced the amount of glycine I pair with NAC upon discovering I am homozygous BHMT 08 (rs651852(A,A)). I have not yet worked out an evidence-based resolution of the issues.
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I dont think we are supposed to feel anything.
Gluthatione is just our master antioxidant and healthy levels of it reduces ROS. So there is nothing to feel.
Maybe just a sense of general wellness.
The key is just to take it daily.
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We can probably say the same for 99% of supplements
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it is an interesting question, isn’t it. I was having this discussion the other day. Based on occasional times when I take no supplements for from 1-3 days, I pretty sure I can detect a subtle difference in my level of energy across the full waking hours but it is not dramatic. Most recently, I added a supplement – Urolithin-A – for which the effects on my muscle performance has been unmistakable. I would have to think about it more but UA might be the only exception.
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Hi,
Can you guys tell me if taking TMG will have the same effect as Glycine? (Taken with or without NAC).
Thanks
Shez
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TMG is basically glycine with some methyl groups so it should, in theory, have the same effect. Maybe even better because it provides your body with much needed methyl groups.
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I have asked four different Ai, they all said no, TMG cannnot replace Glycine.
“The short answer is no, taking TMG with NAC will not have the same effect as taking Glycine with NAC (GlyNAC). While they share some overlapping territory, they are fundamentally different combinations with distinct primary purposes”
“For the specific, well-researched effects of GlyNAC (glutathione boosting, oxidative stress reduction), you must take glycine with NAC. TMG is not a substitute for glycine in this context.
· TMG with NAC is a different combo aimed at methylation and homocysteine metabolism. It’s useful but for different reasons.”
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TMG donates it’s three methyl groups to the body and eventually turns into glycine. By that process (TMG → DMG → Monomethylgylcine → Glycine) you get roughly 3 grams of glycine for every 10 grams of TMG you take.
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Perhaps slightly off the initial question but I would add that addressing methylation related to reducing homocysteine is an incredibly complex issue wherein each wave of research seems to be adding to that complexity. The right amount of TMG can contribute to decreased homocysteine if and only if elevation is due to specific causes but more than the right amount can raise it. What are the conditions and where is the knee of that curve? Good questions? Some of the answers involve specific genetic polymorphisms. Another topic. My only point here is that it is not that difficult to shoot oneself in the foot with a well-intentioned but poorly aimed blunderbuss of experimentation.
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Could you please tell me how to order these products? I am about ready to give up, have been trying to get rapamycin and after a month and a lot of run-arounds, still nothing. Please tell me who and how to order from? Thank you!
The Buy Rapamycin link at the top has a lot of good advice on suppliers.
You can also log in to IndiaMart.com and put up a request and see which pharmacies respond, which may be ones not on the list above but you can still “Take one for the team” and try it out; of course posting if it is a success. I’ve only used IndiaMart 3 times but it has been OK each time.
I’ve been ordering medications & supplements from Thailand/Singapore/Hong Kong for 20+ years and rarely had problems. More recently I’ve been using AliExpress and they are excellent and when things have gone wrong I’ve had refunds/replacements (although I am mainly ordering electronics and household goods, not supplements, from China).
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I did a quick search on AliExpress and I didn’t find anything other than normal supplements so I think it probably avoids selling prescription medications to not have problems.
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Thanks so much!
wow thanks for the studies, they are very good info.
these guys as a prev poster mentioned were taking 6g nac 6g glycine daily omg.
but all the evidence suggests glynac works in extending health and probably lifespan
from the mouse studies, ITP mouse models and these human trials … though Baylor’s College if i am not wrong patented glynac so they have a vested interest in it
Correct.
But Glycine and NAC are not patentable as substances.
- The combination GlyNAC as a therapeutic intervention is patented by Sekhar/Baylor.
- This mainly affects commercial sales of GlyNAC as a pharmaceutical product.
- It does not affect private individuals using it, nor supplement companies that sell glycine and NAC separately.
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if i take 1g nac 3g glycine is it too low for any effects?
how abt 2g nac 3g glycine?
do you happen to know of any studies?
i dont think i can take even 3g nac daily lol
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There is a dose–response uncertainty. It’s still unclear whether, GSH synthesis is linear with dose, if there is a threshold effect and maybe lower doses mainly help glycine deficiency rather than cysteine limitation. The field lacks dose–response mapping.
And we also need another lab to verify the baylor college results in humans.
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Little rodents have a much higher ROS burden than higher primates.
FWIW …
As posted countless times…
“If you wait until you are ready, it is almost certainly too late.”
~Seth Godin
I been doing this using NACET since the original paper was published on and off. And I will continue .
You can wait.
“I am not the waiting type”
Joseph
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