TMG is basically glycine with some methyl groups so it should, in theory, have the same effect. Maybe even better because it provides your body with much needed methyl groups.
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I have asked four different Ai, they all said no, TMG cannnot replace Glycine.
“The short answer is no, taking TMG with NAC will not have the same effect as taking Glycine with NAC (GlyNAC). While they share some overlapping territory, they are fundamentally different combinations with distinct primary purposes”
“For the specific, well-researched effects of GlyNAC (glutathione boosting, oxidative stress reduction), you must take glycine with NAC. TMG is not a substitute for glycine in this context.
· TMG with NAC is a different combo aimed at methylation and homocysteine metabolism. It’s useful but for different reasons.”
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TMG donates it’s three methyl groups to the body and eventually turns into glycine. By that process (TMG → DMG → Monomethylgylcine → Glycine) you get roughly 3 grams of glycine for every 10 grams of TMG you take.
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Perhaps slightly off the initial question but I would add that addressing methylation related to reducing homocysteine is an incredibly complex issue wherein each wave of research seems to be adding to that complexity. The right amount of TMG can contribute to decreased homocysteine if and only if elevation is due to specific causes but more than the right amount can raise it. What are the conditions and where is the knee of that curve? Good questions? Some of the answers involve specific genetic polymorphisms. Another topic. My only point here is that it is not that difficult to shoot oneself in the foot with a well-intentioned but poorly aimed blunderbuss of experimentation.
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Could you please tell me how to order these products? I am about ready to give up, have been trying to get rapamycin and after a month and a lot of run-arounds, still nothing. Please tell me who and how to order from? Thank you!
The Buy Rapamycin link at the top has a lot of good advice on suppliers.
You can also log in to IndiaMart.com and put up a request and see which pharmacies respond, which may be ones not on the list above but you can still “Take one for the team” and try it out; of course posting if it is a success. I’ve only used IndiaMart 3 times but it has been OK each time.
I’ve been ordering medications & supplements from Thailand/Singapore/Hong Kong for 20+ years and rarely had problems. More recently I’ve been using AliExpress and they are excellent and when things have gone wrong I’ve had refunds/replacements (although I am mainly ordering electronics and household goods, not supplements, from China).
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I did a quick search on AliExpress and I didn’t find anything other than normal supplements so I think it probably avoids selling prescription medications to not have problems.
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Thanks so much!
wow thanks for the studies, they are very good info.
these guys as a prev poster mentioned were taking 6g nac 6g glycine daily omg.
but all the evidence suggests glynac works in extending health and probably lifespan
from the mouse studies, ITP mouse models and these human trials … though Baylor’s College if i am not wrong patented glynac so they have a vested interest in it
Correct.
But Glycine and NAC are not patentable as substances.
- The combination GlyNAC as a therapeutic intervention is patented by Sekhar/Baylor.
- This mainly affects commercial sales of GlyNAC as a pharmaceutical product.
- It does not affect private individuals using it, nor supplement companies that sell glycine and NAC separately.
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if i take 1g nac 3g glycine is it too low for any effects?
how abt 2g nac 3g glycine?
do you happen to know of any studies?
i dont think i can take even 3g nac daily lol
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There is a dose–response uncertainty. It’s still unclear whether, GSH synthesis is linear with dose, if there is a threshold effect and maybe lower doses mainly help glycine deficiency rather than cysteine limitation. The field lacks dose–response mapping.
And we also need another lab to verify the baylor college results in humans.
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Little rodents have a much higher ROS burden than higher primates.
FWIW …
As posted countless times…
“If you wait until you are ready, it is almost certainly too late.”
~Seth Godin
I been doing this using NACET since the original paper was published on and off. And I will continue .
You can wait.
“I am not the waiting type”
Joseph
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I take high dose GlyNAC, while waiting for more studies to be published.
Couple questions:
- why on and off, is it one of those things that needs to be done say for couple months once per year?
and - Are you able to notice any positive effects, or is it the case where you know it might be doing something good but not easy to pinpoint (like most other substances/supplements)?
Thanks,
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wow thanks ur very knowledgeable abt this indeed.
thanks for sharing
What is a high dose? Alan Green, MD, now departed, citing this study:
offered:
“The dose for a 70 kilo man was 9 gram of cystine and 7 grams of glycine”
For me a high dose is a dose close to 100 mg/kg body weight of each substance. (Glycine and acetylcystein)
I am using 2400mg NAC and 3g of glycine daily (split with breakfast and before bed) at age 40. I know the older you are, the more effective but there are other benefits besides glutathione restoration. These doses are below what the studies state.
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