A cohort study on IVF outcomes in infertile endometriosis patients: the effects of rapamycin treatment
Results
Rapamycin could decrease markers of enhanced oxidative capacity, 8-OHDG and MDA, and increase antioxidant markers, SOD and GSH-PX. The expression of senescence-related markers p16 and p21 in follicular fluid was significantly lower in the treatment group than in the non-treatment group.
The days of ovarian stimulation were much shorter in the treatment group compared to the non-treatment group, and the number of oocytes obtained and mature oocytes also increased considerably in the treatment group.
Furthermore, Rates of fertilization, implantation and pregnancy were significantly higher in the treatment group, whereas rate of early miscarriage were significantly higher in the non-treatment group.
80 endometriosis women who received rapamycin in the second cycle had significantly better IVF outcomes than their first IVF cycle which did not receive rapamycin. Live birth rate was significantly higher in the treatment group than in the non-treatment group. No structural abnormalities seen in fetuses born to women treated with rapamycin.
Has there been any research on adding Taurine to Rapa for infertility? It seems logical that it would be helpful. As it’s highest in babies and children. Plus is a large portion of breast milk. As it also goes down with age.
It helps my melatonin work much better. I’ve been sleeping better since I started it.
Are there any more articles available about it. There’s no dosage/protocol used information I can find. I’ve taken Rapa for the first 3 days of my cycle (6-8g total) for several months now. It would be nice to find more information to work with.
I’ve emailed the authors to see if I can get the dosing info, and a full copy of the paper. Will let you know if I hear anything back from them.
This study I just cited was the first human study I’ve seen regarding fertility and rapamycin that has been completed. The Columbia University trial of rapamycin for fertility is just starting so will be a few years before we know anything from that study. I think most women are just using longevity dosing of rapamycin as their guideline right now: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?
Anti-ageing molecule boosts fertility in ageing mice
‘Undeniably groundbreaking’ work shows that declining egg quality in older mice can be reversed with a dietary supplement.
Declining fertility in older mice has been reversed by giving the animals a compound already found in most living cells. The process also causes them to produce larger litters. The findings, published today in Nature Aging1, offer clues that could aid the development of treatments for humans with fertility issues.
The chances of falling pregnant — naturally or with assistive technology such as in vitrofertilization (IVF) — become slimmer with age. This can be traced to reproductive cells in the ovaries called oocytes, which deteriorate and decrease in number throughout life.
A molecule called spermidine — first isolated from sperm but now known to have functions in many types of cell — has been shown to lengthen lifespan in yeast, flies, worms and human immune cells. Increased dietary intake of spermidine has also been linked with reduction of age-related problems in laboratory animals, including cardiovascular disease in mice and cognitive decline in fruit flies. But its effects on ageing oocytes were unclear.
So not to hijack this thread, but I find myself unexpectedly pregnant… a little terrified because of my stack to date. Quitting rapa cold turkey of course but wondering if the hive mind here knows of supplements that can be beneficial during pregnancy. Maybe I can do better than a run of the mill prenatal.
Thoughts?
All my grand interventions are now indefinitely on pause. And yes this was not planned and I’m 37 so rapa surely didn’t hurt fertility in my case.
I would back off on most of the supplements and restart with an orientation towards optimal pregnancy health (vs. longevity). Choline is very important, and frequently overlooked:
I somehow knew about Choline from way back. Always supplemented with lecithin in my pregnancies. Of course this is what I meant, as I am stopping all my longevity supplements / interventions but wondering what else is good but little known to take during pregnancy? The equivalent of choline that I haven’t heard of?
I can’t even imagine what it must feel like for my ovaries to be palpable, even the way she describes it. I’ve taken some high dosage in my day, nothing of the sort.
My guest today is Dr. Jennifer Garrison. She is a an Assistant professor at the Buck Institute for research on aging where she runs her own lab and studies women’s reproductive aging. In today’s conversation we discussed:
Menopause and it’s effect on women’s health
Hormone replacement therapy and its benefits
How increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer
The role of the brain in female reproductive aging
I am still touching base with the researcher who has done (is doing) this research (mentioned below) on rapamycin and ovarian function in mice. The paper has not yet been published. Here is his most recent update from today:
Yes, the manuscript is still in preparation after repeated experiments. We are taking some time to replicate experimental conditions to see if the effects we hope to see persist.
Rest assured I will share our work…as much as I would want to when we submit.
Kind Regards,
=====================
This is the information that prompted me to search out the contact info for the researcher, and see if I could get more information:
Okay so the clinical trial dose is 5mg a week for 12 weeks, I assume they are titrating up to that the first week or two. Do we know if they are on birth control until the 12 weeks ends? Is there an amount of time between stopping Rapamycin before becoming pregnant? Does anyone know any further details here??
Neither of us. We were trying but no success - the main reason we were declined for ART was AMH level. was only curious because if increased AMH was due to the improvement of follicle recruitment & growth it’d make sense that the environment (and egg quality) in effect improves or is in some way restored. Since the effect seems to be slowing down eggs being released, that doesn’t imply the improvements that follicle recruitment process optimization would have but I don’t know. Not really personally relevant at this point, that ship has sailed. Just curious. Interest is anti-aging.
