My Rapamycin Symptoms (female)

Hello all,

Attached is my note log for Rapamycin tracking.

I’m especially curious if other women on here have noticed their ovaries becoming palpable. I noticed this after 5 weeks of dosing. Currently stopped. Does rapamycin inflame the ovaries? I tried to look this up, but all I saw was the supposed delayed ovarian aging studies. I was fine with the canker sore, and even the acne, which are resolved now, but this most recent symptom is giving me major pause.


Hi, welcome to the site, and thanks for posting. Can you describe in more detail this experience you are mentioning. I’m a little unclear on the concept of your ovaries starting to feel like they are “touchable”… do you mean that they feel like they are swollen?


Yes, of course. Let me explain. Palpation is basically being able to feel something through light touch. Its a term used in medicine/nursing in the context of assessing a patient (I’m a nurse). They feel more swollen and inflamed; I can feel them just by lightly touching my abdomen bilaterally. I don’t feel pain, but its something I noticed.


I’m not sure my thoughts on this are at all relevant, but as someone who (even now, post menopause, sometimes feels my ovaries (sensing them, not palpation; with or without rapa, unclear)), let me ask: did this happen before rapa, or no? That is, is it an intensified effect of something already palpable, or is an entirely new symptom? Or is that unclear?

For what it’s worth, my surprise symptoms from rapa (aka “side effects”) have included many things that never showed up again. That is, I’ve found my results change across months. The most intense symptoms I had were at 1mg, first time I took rapa, and they never repeated, even at much higher doses.

If you’re anything like that, this may be a passing symptom.


Probably you lost weight and that’s why you can feel your ovaries slightly protruding when on your back. Is it the case?

In my career, I performed too-numerous-to-count pelvic exams and I must say, I never found normal ovaries easy to palpate but easier if associated with an ovarian cyst or tumor. Perhaps you should have an OB-GYN do an exam and ultrasound if needed. Just a thought.

1 Like

Not related to being female, but I AM female, so…

On 5/4, after my first 6mg weekly dose, a red rash slightly smaller than a quarter appeared on my arm. It starts to fade to pink by the end of the week, but then it turns red again after each and every dose. It’s never gone away but it’s also not bothersome.

I do get a little mild acne since starting that is definitely related, but it’s so mild it’s not bothersome and doubt you’d even see it. Mild enough that just using a mild acid on it is enough.

Last week I got my first ulcer/canker sore (not sure!) on the inside of my mouth… never got bad enough to do anything about it.

I’ve had some other red bumps and some itchiness, but those might have been bug bites.

1 Like