Women Taking Rapamycin for Enhanced Fertility / Menopause Prevention?

From The Wall Street Journal:

What if We Could Get Rid of Menopause?

New efforts to boost women’s health and extend fertility depend on developing tools to slow the aging of ovaries

Imagine if women never reached menopause, that dreaded middle-age milestone—or could delay it, or decide when to have it.

Women could remain fertile longer and would have more choice about when to start a family. They wouldn’t struggle with symptoms like hot flashes, mood swings and brain fog in the prime of their careers and family lives.

Even more significantly, women might live longer and healthier lives. Though menopause—a full year without a menstrual cycle—is associated with the end of fertility, it also marks another profound but less recognized change. When the ovaries stop functioning and releasing important hormones, biological aging in women speeds up, increasing the risk of numerous health problems.

Women who reached menopause after age 55 lived two years longer on average than those who reached it before age 40. A 2016 meta-analysis in JAMA Cardiology found that early-onset menopause in women under 45 was associated with an increased risk of heart disease and mortality. A 2021 study in the journal BMC Cardiovascular Disorders found that women who experienced menopause before age 50 had a higher risk of stroke and death. And last year, a meta-analysis that reviewed 22 studies concluded that later menopause was associated with a lower risk of dementia.

Read the full article: https://archive.ph/HdQP8#selection-243.0-265.50

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Some very good news…

A cohort study on IVF outcomes in infertile endometriosis patients: the effects of rapamycin treatment

Results

Rapamycin could decrease markers of enhanced oxidative capacity, 8-OHDG and MDA, and increase antioxidant markers, SOD and GSH-PX. The expression of senescence-related markers p16 and p21 in follicular fluid was significantly lower in the treatment group than in the non-treatment group.

The days of ovarian stimulation were much shorter in the treatment group compared to the non-treatment group, and the number of oocytes obtained and mature oocytes also increased considerably in the treatment group.

Furthermore, Rates of fertilization, implantation and pregnancy were significantly higher in the treatment group, whereas rate of early miscarriage were significantly higher in the non-treatment group.

80 endometriosis women who received rapamycin in the second cycle had significantly better IVF outcomes than their first IVF cycle which did not receive rapamycin. Live birth rate was significantly higher in the treatment group than in the non-treatment group. No structural abnormalities seen in fetuses born to women treated with rapamycin.

Source Paper:

https://www.sciencedirect.com/science/article/abs/pii/S1472648323004194

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Has there been any research on adding Taurine to Rapa for infertility? It seems logical that it would be helpful. As it’s highest in babies and children. Plus is a large portion of breast milk. As it also goes down with age.

It helps my melatonin work much better. I’ve been sleeping better since I started it.

Are there any more articles available about it. There’s no dosage/protocol used information I can find. I’ve taken Rapa for the first 3 days of my cycle (6-8g total) for several months now. It would be nice to find more information to work with.

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I’ve emailed the authors to see if I can get the dosing info, and a full copy of the paper. Will let you know if I hear anything back from them.

This study I just cited was the first human study I’ve seen regarding fertility and rapamycin that has been completed. The Columbia University trial of rapamycin for fertility is just starting so will be a few years before we know anything from that study. I think most women are just using longevity dosing of rapamycin as their guideline right now: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?

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A 45 year old woman is documenting her rapamycin journey via short videos posted on twitter. If you are interested, you may want to follow her.

See this link for the video:
https://x.com/DavisonVideo/status/1704540290566996350?s=20

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Anti-ageing molecule boosts fertility in ageing mice

‘Undeniably groundbreaking’ work shows that declining egg quality in older mice can be reversed with a dietary supplement.

Declining fertility in older mice has been reversed by giving the animals a compound already found in most living cells. The process also causes them to produce larger litters. The findings, published today in Nature Aging 1, offer clues that could aid the development of treatments for humans with fertility issues.

The chances of falling pregnant — naturally or with assistive technology such as in vitrofertilization (IVF) — become slimmer with age. This can be traced to reproductive cells in the ovaries called oocytes, which deteriorate and decrease in number throughout life.

A molecule called spermidine — first isolated from sperm but now known to have functions in many types of cell — has been shown to lengthen lifespan in yeast, flies, worms and human immune cells. Increased dietary intake of spermidine has also been linked with reduction of age-related problems in laboratory animals, including cardiovascular disease in mice and cognitive decline in fruit flies. But its effects on ageing oocytes were unclear.

https://www.nature.com/articles/d41586-023-03224-x

Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging

https://www.nature.com/articles/s43587-023-00498-8

Related News Coverage:

Related threads:

Here: Spermidine delays aging in humans

Here: Generally recognized as safe (GRAS) assessment of a spermidine rich wheat germ extract

Here: Spermidine Impacts Health and Longevity

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Source: https://x.com/antonioregalado/status/1714356131131191657?s=20

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Have you seen this study, a similar effect with AKG

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So not to hijack this thread, but I find myself unexpectedly pregnant… a little terrified because of my stack to date. Quitting rapa cold turkey of course but wondering if the hive mind here knows of supplements that can be beneficial during pregnancy. Maybe I can do better than a run of the mill prenatal.

Thoughts?

All my grand interventions are now indefinitely on pause. And yes this was not planned and I’m 37 so rapa surely didn’t hurt fertility in my case.

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I would back off on most of the supplements and restart with an orientation towards optimal pregnancy health (vs. longevity). Choline is very important, and frequently overlooked:

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I somehow knew about Choline from way back. Always supplemented with lecithin in my pregnancies. Of course this is what I meant, as I am stopping all my longevity supplements / interventions but wondering what else is good but little known to take during pregnancy? The equivalent of choline that I haven’t heard of?

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Any other women experience any rapamycin issues / side effects like this person has? My Rapamycin Symptoms (female)

I can’t even imagine what it must feel like for my ovaries to be palpable, even the way she describes it. I’ve taken some high dosage in my day, nothing of the sort.

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My guest today is Dr. Jennifer Garrison. She is a an Assistant professor at the Buck Institute for research on aging where she runs her own lab and studies women’s reproductive aging. In today’s conversation we discussed:

  • Menopause and it’s effect on women’s health
  • Hormone replacement therapy and its benefits
  • How increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer
  • The role of the brain in female reproductive aging
  • Genetics and ovarian aging
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New Article: The Biggest Breakthrough in Longevity May Start With Menopause (Bloomberg)

Another user report on rapamycin for menopause here:

Here’s where it gets really interesting again! My partner dipped into menopause and then rocketed back out!

See full post here: My DOG, My PARTNER, and ME: A Week by Week Rapalogue - #85 by HigoMe33

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I am still touching base with the researcher who has done (is doing) this research (mentioned below) on rapamycin and ovarian function in mice. The paper has not yet been published. Here is his most recent update from today:

Yes, the manuscript is still in preparation after repeated experiments. We are taking some time to replicate experimental conditions to see if the effects we hope to see persist.

Rest assured I will share our work…as much as I would want to when we submit.

Kind Regards,

=====================

This is the information that prompted me to search out the contact info for the researcher, and see if I could get more information:

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Okay so the clinical trial dose is 5mg a week for 12 weeks, I assume they are titrating up to that the first week or two. Do we know if they are on birth control until the 12 weeks ends? Is there an amount of time between stopping Rapamycin before becoming pregnant? Does anyone know any further details here??

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