Everything above 20 mg/dl LDL is building plaque, and that level is not found naturally except in the extremely rare scenario.
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Can you provide any references for this statement?
Or does this cover it all… AnUser is talking about the goal of targeting very low lipid levels as per this thread: Targeting Unconventionally Low Values of ApoB
Lower LDL than 70 mg/dl to 30 mg/dl better for events 
Post-hoc analysis lower LDL more regression of plaque
People can do as they like. 
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Statins and ezetimibe
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We see plaque regression anywhere from 60-80mg/dL in the studies. Lowering that further just enables further regression, but I haven’t seen evidence yet that plaque can continue to grow at those levels.
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Despite achieving intensive control of LDL-C (mean on-treatment level 58.4 mg/dl), 1 in 5 of these patients demonstrated ongoing disease progression.
https://www.sciencedirect.com/science/article/pii/S0735109710013422?via%3Dihub
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It appears that even small differences in other risk factors are the cause for this progression even at levels below 60mg/dL. Rather than paying for expensive PCSK9i, lowering blood glucose and blood pressure levels is more promising.
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Lp(a) matters, and a lot.
Some people already at 70 mg/dl and can lower further with statins and ezetimibe.
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It would be really nice to see results by LDL-C level stratified by Lp(a) level. I.e. three panels with one panel per Lp(a) tertile, age on X-axis, % disease free on Y-axis, and curve for each LDL-C level. If you are lucky enough to have low Lp(a), you probably do not need to be as aggressive in lowering LDL-C, but I have never seen evidence that shows the risk based on both. (That does not mean it does not exist.)
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No one has mentioned this but why are you taking Dutasteride at such a young age? Are you experiencing hair thinning? If not, why not wait until you do (if ever)? I’ve never heard of Dutasteride or Finasteride helping skin.
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Kudos to you. We need more young people getting started with these interventions at an early age. The sooner, the better.
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Exercise, plant based diet, don’t drink, start rapamycin + acarbose at 25.
I’d almost say start rapa+aca now but concerns about inhibiting brain development.
You also might want to wait if you foresee having kids soon.
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I was able to lower my total cholesterol from 239 to 154 primarily by supplementing with citrus bergamot and flaxseed. I think citrus bergamot is an easy addition with minimal side effects for most people (just take it in the morning to avoid heart burn). I’m not against statins or other cholesterol-lowering medications, but I’d personally rather try lower side effect options first.
Full article: Effect of bergamot on lipid profile in humans: A systematic review (tandfonline.com)
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Yes I started to see mild hair loss, I also have very oily skin and as dut also inhibits type 1 it helps massively with acne. DHT is also somewhat responsible for a breakdown in elastin in the skin so it will help with overall skin aging.
Mainly though I see no reason not to considering I have 0 side effects and it stops hair loss and acne for me.
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First: don’t listen to all the advice on your health from people here (including me) and do your own research.
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Great resource, thank you!
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In young ppl, caloric restriction is arguably more important than exercise [1]. Exercise by itself encourages anabolic hyptertrophy and activation of the mTor/IGF-1 axis, which constitutes the opposite mechanism underlying the longevity benefits of validated interventions like rapamycin. In addition, exercise in general increases oxidative stress and after a particular point it has further negative effects (i.e overtraining). 7h/week is already far above the minimum recommended 2.5h/week.
Of course, exercise will always be incomparably better than being sedentary. Also, consider the option of combining caloric and protein restriction, with moderate exercise; it’s harder, but it’s the regimen I’m personally following. Regardless whether you choose to do a form of dietary restriction (but moreso if you do!), I would suggest you begin tracking your dietary micronutrients meticulously.
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How relevant is Rapamycin’s mTOR inhibition in the brain for an average longevity dosage, eg. 5 mg in humans?
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Probably minimal… See Joan mannick’s comments in the first video at this link. She says they have seen minimal penetration of the blood brain barrier with rapamycin…
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