In young ppl, caloric restriction is arguably more important than exercise [1]. Exercise by itself encourages anabolic hyptertrophy and activation of the mTor/IGF-1 axis, which constitutes the opposite mechanism underlying the longevity benefits of validated interventions like rapamycin. In addition, exercise in general increases oxidative stress and after a particular point it has further negative effects (i.e overtraining). 7h/week is already far above the minimum recommended 2.5h/week.
Of course, exercise will always be incomparably better than being sedentary. Also, consider the option of combining caloric and protein restriction, with moderate exercise; it’s harder, but it’s the regimen I’m personally following. Regardless whether you choose to do a form of dietary restriction (but moreso if you do!), I would suggest you begin tracking your dietary micronutrients meticulously.
Probably minimal… See Joan mannick’s comments in the first video at this link. She says they have seen minimal penetration of the blood brain barrier with rapamycin…
With all these drugs identified as potential longevity drugs, there are risks and rewards. Some risks we know of (like mouth sores) but others we don’t know about, or may not know about, just because they have not been tested longer term in healthy populations.
And of course there is uncertainty about the benefits of taking rapamycin (for healthy humans)… the recent marmoset data is the best data we have right now in terms of translation to humans (likely, but the marmosets are taking the drug at very high doses… which humans can’t do because of immune suppression and infection risks)… so our current dose is much lower than that which the marmosets are taking. So, taking rapamycin between age 21 and 25 “might” give you an extra 1% or so lifespan improvement, at some unknown risk. For me - its not worth the risk, since the benefit at that age seems pretty minimal. And the “opportunity cost” of waiting is quite low - new drugs and approaches will likely come out that you can leverage later. You can always start rapamycin a little later… in four or five years we’ll know a lot more from people on this forum, and hopefully from other research.
