Awesome data, thanks!
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Was that 12mg taken with oil or grapefruit juice?
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Its really hard to know how many people are taking rapamycin (for longevity) right now. We know that Dr. Alan Green, who has been prescribing it the longest of anyone (4 years+) - has about 1,000 patients. There are perhaps another 20 or 30 doctors prescribing it around the world (that I can find) -but most of them have only been doing it for the past year or maybe 2 years. Perhaps each of them have 100 or 200 patients… so another few thousand people, and from our earlier survey we might estimate that 50% of people see doctors, while another 50% are just buying the medication and taking it: Poll: How do you get your Rapamycin: Doctor Prescription, or Just Buy It?
So - perhaps a total of somewhere between 5,000 and 12,000 people worldwide taking rapamycin right now for longevity…
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What’s the longest anyone has taken Rapamycin on a weekly or fortnightly basis for longevity?
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Yes, I experienced lots of minor effects after taking it. Some good and some Meh. For instance, I had a feeling of a euphoric fatigue fit the first two days after taking Rapamycin. I enjoyed that. I also sometimes got canker sores, acne, or rashes which are not enjoyable.
I feel great, but that could be the placebo effect. My epigenetic age went down 7 years, but that could be other factors as well. Also my epigenetic age is still higher than my chronological age.
I think the worse shape you are in the more positive effects Rapamycin will have on you. Many people in tip top health feel no changes at all.
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Wouldn’t that be Dr. Mikhail Blagosklonny?
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Great analysis. I guess we’re pioneers here. Hopefully we’re on the right side of history lol
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Wow, interesting regarding your epigenetic age being higher. I consider myself in good health but have never had my blood done to really know for sure. So while I’d assume my epigenetic age is lower than my chronological age, I guess I really don’t have a clue.
I’m starting to assume I’ll see/feel very little benefit but hoping I can see the difference in my blood tests to know it’s working under the surface.
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Early 40s here, been doing this for about 5 months now. I love rapa day each week because I feel better on that day than any other, lots of energy, physical and mental. Will be doing my first bloodwork since starting next week so I’m very curious to see if there are any changes. Overall I’m super happy to get a little burst of energy and know that I’m hopefully preventing bad things down the line.
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I’m 48 and just started taking Rapamycin. I’m close to talking to family, but I figured I’d work up to a solid dose over a month or two and see how my body reacts. After all, my family share a good amount of my genetic makeup.
When I tell them I think I’ll share some videos and blogs from elsewhere on this site. Plus give this site.
When you get your blood tested, if you want to use the Levine Phenotypal Age calculator check this post A Friendly, Biological Age Reduction Competition? - #60 by HigoMe33
It’s fun that a group of us are all in our 40’s and beginning now. Let’s get together in 60 years and have a party!
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Well, I took a spit epigenetic test and it says my epigenetic age is 59. I took a blood sample analysis at Aging.ai and it says my age is 28. If you average the two together, you get my real age. So, it just goes to show you that age testing is still quite variable.
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Same here I’m 48 and would’ve have started earlier If I’d have had access to Rapa. I’ve been a longevity nerd for years and thought it was out of reach until I stumbled upon this site. I’m very grateful to have found it. I do think that it’s incredibly early though. I personally don’t feel comfortable trying to persuade my family to get on it. While I’m feel fairly confident that we’ll find out conclusively Rapa does extend lifespan in the near future there are risks and uncertainty involved. I get the impression that we’re in the minority. Not everyone is prepared to take unproven drugs and not everyone should.
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G’day Tbiz
I’m 43 and have been taking Rapa for just over two months now. I followed RapAdmins advice and ramped up slowly (1mg a week, now at 6mg). I have not experienced any positive or negative side effects thus far, apart from psychological (feeling positive about the future).
I am quite fit, lean, eat healthy and take some other supplements / medications like most others on the site.
Cheers
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Olive oil. I would advise against GFJ
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Sounds like we’re in similar boats regarding fitness. I need to really dial down any expectations and just hope to see changes in blood work to know it’s having a positive impact. Thanks!
I have been taking rapamycin for a year and have seen no positive effects on any of my blood work, only negative effects. In fact, I had to lower my dosages to get my blood markers back to normal. My markers are still not as good as they were before I started rapamycin.
My personal positive effects of rapamycin are related to its positive effects on my skin and greatly improved sleep quality. I am old and old people often have sleep problems like getting 8 hrs of good sleep at night. I am now sleeping like I did when I was a teenager.
The anti-cancer effects of rapamycin have reduced the number of actinic keratoses that I have to essentially zero. Due to excessive sun exposure to the sun when I was young I developed chronic actinic keratosis, which caused me to seek treatments at least twice a year for decades. I haven’t had to see my dermatologist for over a year now and don’t plan to see him anytime soon.
Bottom line: While rapamycin has proven life-extension effects in mammals, don’t be surprised if your blood work doesn’t look better after starting rapamycin. This was a surprising result for me and has not been properly explained.
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Wow, interesting mix of results! I haven’t heard anyone talk about their blood work being worse off since starting rapamycin. Good to know!
It seems that the positives are outweighing the negatives for you? It sounds like you aren’t planning to stop the rapamycin?
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TVBiz, Pay attention to that knee pain. I’m quite a bit older than you and have slowly moved away from jogging to activities that don’t seem to wear my joints as fast as I think jogging did. I still walk and hike, but have incorporated swimming and stationary cycling to reduce joint stress. Strange as it may seem doing hundreds of squats in sets once a week doesn’t seem to cause joint pain. Collagen peptides may be helpful, but I certainly haven’t noticed any improvement with that supplement. And, rapamycin to improve the joints? Well, I’m not counting on rapamycin for help in that area. But, it’s totally unknown at this point. Oh, and one more thing about joint pain, if your are overweight, losing weight can reduce wear and tear on the joints and possibly reduce pain.
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Yes, in spite of questionable blood work results, I am still a believer in rapamycin and plan on taking it for the rest of my life. BTW, I was in excellent shape and my blood work was also very good before I started rapamycin. My epigenetic age was younger using the Levine calculator before I started taking rapamycin. Since I didn’t have any idea that rapamycin would affect my actinic keratoses or sleep, I feel that they were not placebo effects.
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