Unfortunately, I didn’t see the value in paying to take these tests ($100 TruMe and $350 GlycanAge) because at the time I didn’t think it would make a difference. Waste of money.
In hindsight, it is my biggest regret. So I have my TruMe Epigenetic Methylation after one year with a biological age of 50 years… chronological age 63 years.
GlycanAge test after 1.5 years of rapamycin… biological age based on inflammation was 37 years… my chronological age 63.5. Most recent test a few months ago say 42 biological age. A 23 year difference.
I was able to compare my Levine blood panel age prior to Rapamycin because I have my annual work physical blood panels past 10 years.
Prior to Rapamycin my chronological age 62 years… Levine biological age 67 years… yikes 5 years older!
After 3 years of rapamycin chronological age 65 years. Levine biological age 50 years. A 15 year plus reverse of the 5 years older figure from previous Levine test. Total 20 biological age reversal.
@Agetron, As far as I can tell, you have good genes and you’re a lifelong fitness buff, which may contribute more than rapa to your test results. I can see how you’d like to preserve most of your current fitness level for as long as you can, a worthy goal in itself. I think that you’d be safe to assume that you’re aging but more slowly than most.
Hahaha… you wrote: “As far as I can tell, you have good genes and you’re a lifelong fitness buff…”
Actually I hate going to the gym and only have been doing muscle resistance for about an hour for the past 6 years. Prior to that I liked my soda, chips and dip! Liked them a bit too much.
So much for lifelong fitness buff… I hate going to the gym - but do - only every other day!
That said, I think anyone can do what I have done - slow, consistent and steady. And, get to a healthier place - so I am shocked that I have no atherosclerosis on my coronary calcium scan zero… and my almost no inflammation and great epigenetic methylation. The rapamycin has corrected aging neurology issues, arthritis, improved memory, better skin, teeth, hearing and sight… euphoric, strong muscles. Overall a reversal to my earlier self.
“The rapamycin has corrected aging nuerology issues, arthritis, improved memory, better skin, teeth, hearing and sight… euphoric, strong muscles. Overall a reversal to my earlier self.”
You got all that out of rapamycin? You should probably stick with it.
Thank you for the interesting post.
I haven’t seen anything to suggest that a high dose of rapamycin would affect mTORC2 but just that it would dial down mTOR1 further. However there is some evidence from 2006 (can find study if needed) to say that continuous rapamycin will start to dial mTORC2 down which may be leading to some of the disappointing (yet still very good ) biological age results.
Has anyone got information as to why affecting mTORC2 might be detrimental to human health? The articles talk about mTORC2 overseeing actin, endocytosis, mitochondrial energy and cell division, so perhaps there could be a low sporting energy, and a muscle catabolic component involved?
This is something Dudley Lamming at U. Wisconsin has written a great deal about. This thread has some information, and Dudley has a number of papers that touch on the topic, which he provides links to in the thread I share below…
Hey Duncan… David Sabatini explains how continuous rapamycin will stop MTOR 1 from creating MTOR2.
In this podcast with Attia and Kaeberlein…he explains how it happens. Fascinating.
The Drive # 272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more
Link: https://youtube.com/watch?v=O67pvKxio10&si=9mWMmDQpy3m-x12i Go to point 47:38 - of 3:01:28
From a Matt Kaeberlein, PhD private message in November Re: Rapamycin higher dose - "I honestly don’t know. I understand Misha’s (Mikhail Blagosklonny) rationale for pushing it as high as possible until you get to side effects. My concern there is that you might be getting to side effects and not know it right away or at all (silent pathology) until it’s too late to reverse the damage. I have no evidence for that, but it’s a concern I have.
I absolutely think it’s possible that 36mg could be net detrimental to health while 6-8 mg could be beneficial. I am certain the optimal dose will be different for different people." Kaeberlein 2023
He hasn’t gone into depth on his rationale, but one of his statements has been that higher doses likely help in getting rapamycin through the blood brain barrier. We’ve had some discussions on this and a look at the research in this area, in this thread: Rapamycin and the Issue of Getting Through the Blood Brain Barrier
I know this is an old post but if you’re still here, I just had concerning A1C results as well. I had it as low as 4.8 in June 2023 but my recent test was 5.6.
The only two things I can point to are:
discontinuing DHEA (my recent level after stopping was 104, so I just went back on 50mg)
going from 5mg Rapamycin every week to 10mg every other week. It’s the same total dose per two weeks though. I’m going to take a month off and restart at 5mg per week.
I struggle to think of what else could have increased it.
A similar thing happened to me late last year: my hemoglobin, hematocrit, and MCHC were low; 11.3, 36.4, and 30.8. For the previous year I was taking 6mg rapamycin with grapefruit juice every 12 days. The above blood numbers had been trending down before I took notice in November.
Since early January, I have been having 1-2 oz of liver (beef, chicken, pork) per day, doubled by multi-vitamin from 1/2 to 1 full tablet (with iron included), made sure I had black pepper with iron to increase absorption, and separated consumption of iron foods from dairy and high fiber foods that might interfere with iron absorption. And I am taking a break from rapamycin.
I have been using a home hemoglobin test for several weeks (seems pretty accurate), and have gotten it up to a barely normal 13.6. Once I hit 14, I’ll resume rapamycin at a lower level and monitor the situation.
By the way, I also noticed that a late January measure of RDW had suddenly jumped from 14.1 to 15.9. Does that indicate lots of new red blood cells that made the mean width vary, since I understand that new RBCs are larger than mature ones?
Are we suggesting that rapamycin will lower the iron level in our body? My iron level is been 2x to 3x above the maximum normal level. I hope that is good news for me.
I tried donating blood before. My blood pressure collapse and they told me not to come back . Anyway it used to be 5x over the upper limit. I’ve managed to reduce it but it is still consistently 2x over the limit.
My serum Iron has been reasonably consistent, but ferritiin has trended down. Doing weekly blood tests involves losing 10-15ml of blood a week. However, I don’t think that is the cause of the reduction in ferritin.
. Anyway it used to be 5x over the upper limit. I’ve managed to reduce it but it is still consistently 2x over the limit.