More Rapamycin Might Not Be Better – I upped my Rapamycin Dosage to 38ng mL on average for the past 7-months
Looking back on my Rapamycin history. After dosing on 6mg Rapamycin/Sirolimus for one full year, I decided to do a biological test to see if I was getting any benefits internally. Based on reviews, TruMe seemed to be a good one for DNA Methylation through a spit test. My results not only impressed me, also but the CEO of the TruMe Company with a 12.4 year difference. Biological I was 51 years and chronological I was 63 years at the time. Explaining to the CEO I was taking Rapamycin and Metformin – she felt it was an accurate assessment of my biological age 51 years. Congratulations!
I stopped the Metformin due to off and on diarrhea spells and it making me gassy. I re-tested with TruMe 6-months later - partially to confirm that the test was accurate the first time. I was not too surprised to see I was now biological age of 52 years - chronolgical age was 64 years with a 12 year difference. I had lost almost a half year so a bit of acceleration, but felt pretty good.
It was during this time, based on Mikhail Blagosklonny’s comment to go as high as possible without side effects and other users looking at going for a higher dose, that I started using Rapamycin with Grapefruit Juice (GFJ) – I was hitting ranges of upper 30’s to 56 ng/mL and having 3-day bouts of diarrhea. I finally was able to get some consistency at 6mg Rapamycin and GFJ and hitting 36 ng/mL based on my LabCorp tests. This was my dose regiment (6mg and GFJ) from late July thru end of November.
My third and most recent TruMe test came back a week ago and had me 54.2 years biological age to my 64.8 chronological years.
I had lost some ground. My biological age increased almost 2.5 years in the 6 months. So it would appear that the higher rapamycin dosing has caused me to lose some of the anti-aging benefits I gained on a lower dose. To be 64 chronological years with a 54 biological age is not bad, a 10-years difference. But, it was better when I was doing a lower dose with an almost 13 year’s difference between the two.
Here are my TruMe reports in order from 1st 2nd and 3rd - current.
But read on – my accelerated aging on a higher dose of Rapamycin gets worse.
TruAge Test by TrueMe past 3-tests.pdf (123.5 KB)
Another biological aging test being used by the PEARL Rapamycin Human Clinical Trials is GlycanAge, so I decided to try it. This uses a blood sample - more thorough, more accurate and more expensive. I did my first test at age 64 years – I had been on rapamycin at 6mg-8mg only doses for 1 year 8 months. My report came back that I was 37-years biological age based on my glycans and lack of inflammation. A 27-year age difference from my chronological age. As I stated, feeling more Rapamycin might be better, after that test I significantly upped my Rapamycin dose to 38 ng/ml to 56 ng/mL and took on a very lean/shredded body look. Very little body fat anywhere. After 7-month of the higher Rapamycin dose I re-took the GlycanAge test. I was a bit surprised and disappointed to see I had lost 15-years biologically on the higher dosage since my first glycan test. My latest GlycanAge test has me at biologically 52 years and chronological age 64. A 12-year difference and nothing to complain about. But, it had been much better 27-year difference. I feel like I won the lottery and then pissed it away. Very frustrating. Here are my GlycanAge tests.
GlycanAge results November 2022.pdf (92.2 KB)
When I significantly upped my rapamycin, on both my TruMe and GlycanAge tests I had aged faster in the past 6 months. My routine is pretty consistent in food, supplements and exercise. In the past 7 months the only significant change to my diet/supplements and exercise routine has been the significant increased Rapamycin dose weekly. Perhaps I was taking my MTOR1 too low for too long and my MTOR2 has been affected. I don’t know. But, at least for me it appears more Rapamycin is not better. I want to try and regain back my better biological age numbers.
I am re-evaluating my higher dosage regiment and have decided to go back to the 6mg dose again with Acarbose - not Metformin – and no GFJ. I have never had a rapamycin break in the past 2.5 years of use. I have used Rapamycin every week non-stop. I am thinking of doing a reset. Going off rapamycin for one month and slowly reintroduce it 2mg first week; 4 mg second week and settle on 6mg at third week. Maybe take a month break from Rapamycin every 6-months is in order too. I will do this new protocol and retest with TruMe and GlycanAge in 7-months and see where I am. Hopefully, I am able reverse and also slow down the aging to my prior numbers.
I am definitely a rapamycin believer. My health issues resolved or improved with rapamycin include: eliminated choking issues (dysphagia); eliminated arthritis; decreased varicose veins; enlarged open veins; thickening of skin (crepe skin gone); significant improved memory; increased energy and euphoria; improved gums; increased muscle strength; reduced visceral and other fat from my body.
The best we can do is keep testing. Find a few baselines and test any changes we make. I was expecting to have at minimum stalled or slow my age progression with the higher Rapamycin dose.
Seeing an acceleration in aging on two very different tests has me concerned about taking higher doses of Rapamycin. In my case, it appears that more Rapamycin is not necessarily better. As Drs. Peter Attia & Matt Kaeberlein state, it is about the dose. Both are Rapamycin users - neither one doses higher than 8mg and take breaks. On this site - we guess, we try, we learn and we share with each other.
