Maraviroc Fights Middle-Aged Memory Loss (And Muscle Aging)

FWIW, my sis in law was looking for something that I found on the Indiamart website.

I contacted 3 well known vendors and they all confirmed it was not actually available in India.

This one might be available, but I learned they do post things as click bait.

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There is a pharma company in India producing it, but it looks to be a smaller company. I’m suspicious / leery of smaller Indian Pharma companies as their quality control tends to be worse than the major International Pharma. Another approach might be to contact a doctor through something like Push Health and try to get a US-based prescription and source.

From Gemini: Based on your request, the manufacturer and company details for Axentri 150mg Maraviroc Tablets are listed below.

Manufacturer Identification

  • Manufacturer: Emcure Pharmaceuticals Ltd.1
  • Headquarters: Pune, India2
  • Therapeutic Class: CCR5 co-receptor antagonist (Antiretroviral)3

Company Website

Product Context

Axentri is a branded generic version of Maraviroc , an entry inhibitor used in the treatment of CCR5-tropic HIV-1 infection.4 Unlike other antiretrovirals that target viral replication after cell entry, Maraviroc blocks the CCR5 receptor on the CD4 cell surface to prevent viral entry.5 As a prescription pharmaceutical, specific product pages may be restricted depending on regional compliance laws; however, the manufacturer’s corporate site provides general portfolio information.


Just a note : Rosuvastatin in some patients is associated with decreased cognition that mimics long covid. I certainly found that was the case for me. By switching to Atorvastatin (or Pitavastatin) for 7 days and then switching back to Rosuvastatin for 7 days (try it a few times) you can quickly determine if you someone who is sensitive to the effects.

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Thanks for the info. I ended up ordering from Shree Signify Exim. Shipped cost is about 1/3 of that of GoodRx prices.

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Been on it for three weeks at 150mg BID. Doing rehab and too early to be certain but subjectively feeling progress to be easier.

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Great to hear. Keep us updated as time goes by!

More interesting news on Maraviroc that I missed earlier (July, 25):

  • Maraviroc as a Senomorphic: The study screens for compounds that can disrupt this signaling and identifies Maraviroc (a CCR5 antagonist) as a potent senomorphic . Unlike senolytics (which induce apoptosis in senescent cells), Maraviroc suppresses the inflammatory SASP “chatter” between cells without killing them.
  • Mouse Model Results: As noted in your text, aged mice treated with Maraviroc demonstrated:
    • Functional Gains: Significantly improved grip strength and running endurance.
    • Morphological Changes: Increased muscle fiber cross-sectional area (reversal of atrophy).
    • Cellular Impact: Reduced markers of cellular senescence (e.g., p16, p21) and decreased inflammatory infiltration.

Dosing (Preclinical)

The study utilized two dosing regimens in mice that yielded positive results:

  1. Injection: 10 mg/kg intraperitoneally every other day for 12 weeks (started at 18 months old).
  2. Oral/Dietary: 1.5 mg/kg per day mixed into food for 15 weeks (started at 21 months old).

Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia

Cellular senescence is a hallmark of organismal aging but how it drives aging in human tissues is not fully understood. Here we leverage single nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first senescence atlas. We demonstrate the intra- and inter-populational transcriptomic and epigenomic heterogeneity and dynamics of cellular senescence. We also identify commonalities and variations in senescence-associated secretory phenotypes (SASPs) among the cells and elucidate SASP mediated cellular interactions and niche deregulation. Furthermore, we identify targetable SASPs and demonstrate the possibility of using Maraviroc as a pharmacological senotherapeutic for treating age-associated sarcopenia. Lastly, we define transcription factors that govern senescence state and SASP induction in aging muscle and elucidate the key function and mechanism of JUNB in SASP activation. Altogether, our findings demonstrate the prevalence and function of cellular senescence in skeletal muscle and identify a novel pharmacological intervention for sarcopenia.

https://www.nature.com/articles/s41467-025-61403-y

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A post was split to a new topic: Existing HIV Drug Reverses Muscle Aging by purging “Zombie Cell” Signals

Hey @NickG,

Any effects (good/bad) to report since you’ve been taking it for 2 months already? Have you done any lab tests recently(after starting Maraviroc) and what were the results? Thanks,

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Walter_Brown, I assume that you’re using a 150 mg pill. If that is the case how do you manage to cut it into 10 segments?

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It is available from India.

Axentri Maraviroc Tablets

"In India, Maraviroc is primarily sold under the brand name Axentri.

Brand Information

Manufacturer: Axentri is manufactured by Emcure Pharmaceuticals Ltd…

Availability: It is available in 150 mg and 300 mg tablets, typically sold in bottles of 60 tablets.’

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A little about Emcure Pharmaceuticals. The lack of much export to more developed countries gives me a bit of concern about quality, as does the regulatory problems at that specific factory they produce the medicine at. I wish there were an easy, cost-effective way to have the medicine evaluated:

The following profile details the size, financial standing, and quality reputation of Emcure Pharmaceuticals Ltd. as of late 2025.

Quick Snapshot

  • Industry Rank: 13th Largest in India (Domestic Sales)
  • Market Cap: ~₹27,000 Cr ($3.2B USD)
  • Primary Focus: Gynecology (#1 in India), HIV Antivirals, Cardiac, and Biologics.

1. Ranking & Financial Magnitude

Emcure is a significant Tier-1 player in the Indian pharmaceutical market (IPM), distinct for its heavy reliance on the domestic market compared to its export-heavy peers.

Metric Value / Rank Context
India Rank 13th Based on domestic sales (MAT FY24). It is the 4th largest company in its specific “covered markets” (therapeutic areas it competes in).
Revenue (FY24) ₹6,658 Cr (~$800M) Domestic sales contribute approx. 48% of total revenue, which is higher than many Indian pharma peers who rely more on US exports.
Revenue (TTM) ₹8,449 Cr (~$1B) Trailing 12-Months as of Sept 2025. Growth has accelerated recently, driven by new product launches.
Market Cap ~₹27,000 Cr Listed on NSE/BSE in July 2024. Currently valued as a mid-cap pharma stock.
Key Segments #1 in Gynecology Also holds leadership positions in HIV (Antivirals) and Iron supplements.

Note on Growth: Emcure has outperformed the Indian Pharmaceutical Market (IPM) growth rate in domestic sales over the last 3 years (CAGR of ~10% vs industry ~8%).


2. Quality Reputation & Regulatory Status

Emcure’s reputation is currently in a “Recovery and Redemption” phase. Historically plagued by severe regulatory issues, the company has made significant strides in 2024–2025 to clear its compliance record.

The “Red Flag” History (2015–2019)

  • Warning Letters: The company suffered severe reputational damage due to US FDA warning letters in 2016 and 2019 for its Hinjewadi (Pune) facility.
  • Issues Cited: Regulators cited data integrity breaches, poor aseptic processing techniques, and failure to investigate batch discrepancies. This effectively locked them out of significant US export opportunities for years.

Current Status: Significant Improvement (2024–2025)

As of December 2025, the company has successfully cleared multiple critical inspections, signaling a turnaround in manufacturing quality.

  • :white_check_mark: Gujarat (Kadu) Facility: Received “No Action Indicated” (NAI) status from the US FDA in December 2025 (Inspection Oct 2025). This is the highest compliance rating, meaning no objectionable conditions were found—a major “clean chit.”
  • :white_check_mark: Sanand (Oncology) Facility: Concluded a US FDA Pre-Approval Inspection in July 2025 with Zero Observations.
  • :warning: Pune (API) Facility: Received 2 Observations (Form 483) in Feb 2025. However, this was later classified as VAI (Voluntary Action Indicated) in April 2025, meaning the FDA accepted their corrective plan and the facility is compliant enough to continue operations/exports.

Summary Verdict

  • Commercial Strength: High. They are a dominant domestic force with a unique “brand-building” model rather than just generic commodities. They own the gynecological niche in India.
  • Quality Risk: Moderate (Improving). While the historical data integrity issues were severe, the “Zero Observation” and “NAI” results in late 2025 suggest they have overhauled their quality management systems. They are no longer in the “danger zone” they were in 5 years ago.

Emcure manufactures Axentri (Maraviroc) at its primary solid oral dosage facility in Pune, Maharashtra .

Based on the product packaging and regulatory filings, the specific factory details are:

Manufacturing Location

  • City: Pune, Maharashtra
  • Facility Zone: Hinjewadi (a major IT and Biotech park in Pune)
  • Specific Address:

Emcure Pharmaceuticals Ltd. Survey No. 255/2, Phase-I, Hinjewadi, Pune - 411 057, Maharashtra, India.

Facility Context

  • Role: The Hinjewadi plant is Emcure’s headquarters and flagship facility. It is responsible for manufacturing the majority of their HIV antiretrovirals (ARVs) and solid oral formulations (tablets/capsules) for both the Indian domestic market and export to emerging markets.

Based on the manufacturing location of Axentri (Maraviroc) at the Hinjewadi, Pune facility, here is the specific quality and regulatory status for that site.

Facility Snapshot: Hinjewadi Phase-1 (Pune)

  • Role: Emcure’s Headquarters & Flagship Facility (Solid Orals & Injectables).
  • US FDA Status: Restricted / Official Action Indicated (OAI)
  • Last Major Regulatory Action: Warning Letter (August 2019)

Detailed Quality Reports & Inspection History

Unlike Emcure’s newer facilities in Gujarat (which recently received a “clean” status), the Hinjewadi facility has a troubled regulatory history with the US FDA that has not yet been fully publicly resolved “close-out” as of late 2025.

1. The “Import Alert” (Ban) Status

  • Status: The facility is under Import Alert 66-40.
  • Meaning: This effectively bans most products manufactured at this site from entering the US market. The FDA placed this ban due to violations of “Good Manufacturing Practices” (GMP).
  • The “Exception” for HIV Drugs: Crucially, the US FDA often grants exemptions for essential drugs where there is a shortage or medical necessity. Certain antiretrovirals (like Cidofovir and likely Maraviroc/Axentri) have historically been excluded from the ban, allowing them to be exported despite the facility’s overall non-compliant status.

2. Key FDA Observations (The “Red Flags”) The 2019 Warning Letter (which followed a 2015 ban) cited specific quality failures at Hinjewadi that impacted its reputation:

  • Data Integrity: The most damaging finding was that data regarding sterility and quality testing was not reliable. The FDA cited instances where test results were potentially manipulated to pass batches that should have failed.
  • Sterility Issues: For injectable lines, investigators found poor aseptic techniques (e.g., operators moving too quickly, disrupting sterile airflow) and contaminated media plates.
  • Environmental Monitoring: Failure to properly monitor the manufacturing environment for bacteria/contaminants.

Current Verdict on “Axentri” Quality

  • For the US Market: The facility is not considered fully compliant with US standards, but Axentri (as an HIV drug) likely falls under a “medical necessity” exemption allowing it to be sold.

Summary: While Emcure as a company has cleaned up its act in 2024–2025 (clearing inspections at its Sanand and Gujarat plants), the Hinjewadi facility where Axentri is made remains the “legacy problem” site with unresolved US FDA warning letters. The quality is sufficient for domestic approval but has historically failed to meet the higher bar of US regulatory clearance.

Am I meant to be cutting it into 10 segments?! :flushed::scream:. I’ve been taking 150mg twice daily (or a total of 300mg per day) for the last month. Feel fine and both my neuro- physiotherapist and personal trainer have noted fresh plasticity and progress.

Walter_Brown

Been on it for three weeks at 15-mg BID.

My question was based on your statement above of 15-mg BID several posts back. Now, should the dose be 15 mg BID or 150 mg BID? I’m not sure, but it seems to me that I saw somewhere in a RapAdmin post on Maraviroc that 15 mg BID or 30 mg daily would be appropriate.

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Yes, I think it was 30mg but I’d cut 150 into four pieces and do it once per day to start and then maybe go twice per day. I wouldn’t go more than 75mg daily.

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Apologies, was a typo - will correct original post. Was meant to read 150mg. My mistake :blush:

Have you ever tried LDN 3mg-4.5mg. A lot of people seem to have good results with it. I use it and it is an excellent medication for aches and pains (but never had covid so can’t speak to that). Maybe worth a shot.

@desertshores, are you considering it? At almost 81, I’m watching this space carefully. Dose, frequency, mechanism, etc.

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Not just yet, I’ve already got so many meds I’m loath to start another one.

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I’ve been exploring dosing approaches to try and replicate the effects from the mouse studies. The behavior of maraviroc in humans vs. mice is so different, a compounded micro dose may be needed. For now the approach I’m going with is to split 150 mg tablet into quarters (37.5 mg) and dose every 2 weeks. Here’s the analysis of that approach from Grok:

Dosing Interval to Approximate Mouse Study Approach

To address your question directly: yes, dosing frequency should ideally be based on the ratio of duration of inhibition to no inhibition to maintain a similar proportion of time under CCR5 inhibition, as this could better replicate the “pulsed” exposure profile in mouse studies where transient, short-lived inhibition (followed by extended troughs) led to senotherapeutic effects like reduced senescence and improved muscle/memory outcomes. However, this ratio must be adjusted for species differences in physiology (e.g., metabolism, half-life, and aging time scales) to ensure biological relevance—direct ratio matching without scaling could result in overly extended intervals that may not align with human senescence dynamics.

Mouse Exposure Profile Recap

  • In key studies (e.g., 2025 senescence/sarcopenia models), mice received 10 mg/kg IP every 2 days (48-hour interval).
  • Mouse half-life ~0.9 hours leads to rapid clearance: peak concentrations (~3600 ng/mL) drop below thresholds for meaningful inhibition (>30% occupancy, requiring ~793 ng/mL due to low mouse CCR5 affinity) within ~2 hours.
  • Thus, ~2 hours of inhibition followed by ~46 hours of no inhibition per cycle (ratio 1:23, or ~4% time under inhibition).
  • This pulsed profile (short bursts with long recovery) is thought to drive the “hit-and-run” senolytic-like effects without constant blockade.

Human Exposure Profile for Low Dose (37.5 mg Oral)

  • A single 37.5 mg oral dose achieves peak concentrations ~17-28 ng/mL (scaled from 225 ng/mL for 300 mg single dose, adjusted for non-proportional PK and lower bioavailability ~20-23% at <100 mg).
  • Human half-life ~14-18 hours (mean 16 hours) and high CCR5 affinity (KD ~0.089 ng/mL for 50% occupancy) result in prolonged high occupancy: >95% at peak, sustained >30% (threshold ~0.038 ng/mL) for ~5-6 days (time to drop from Cmax to threshold ~141 hours post-peak, approximating total duration above threshold).
  • This creates a much longer inhibition phase than in mice, even at minimal doses.

Recommended Dosing Interval: Every 2 Weeks (Scaling the Ratio with Allometric Considerations)

  • Direct Ratio Matching: To preserve the mouse 1:23 ratio (inhibition:no-inhibition), human no-inhibition would be ~115-138 days for a 5-6 day inhibition duration, yielding an interval of ~120-144 days (every 4-5 months). However, this ignores slower human metabolism and aging processes, potentially leading to insufficient pulses over time for cumulative senotherapeutic benefits.
  • Adjusted with Allometric Scaling for Time/Frequency: Pharmacological translation often scales time intervals (e.g., dosing frequency, half-life effects) by body weight^0.25 (~7-8 for mouse [0.025 kg] to human [70 kg]), as this accounts for metabolic rate differences and better predicts human PK/PD from animal data. Scaling the mouse 48-hour interval by ~7-8 gives ~14-16 days in humans.
    • This maintains a scaled ratio: Human inhibition ~5-6 days (mouse 2 hours * ~18x half-life ratio, but capped by allometric ~7-8x), no-inhibition ~9-10 days (mouse 46 hours *7-8), ratio ~1:1.8 (adjusted from 1:23 to reflect faster mouse biology).
    • Result: ~35-40% time under inhibition per cycle (higher than mouse’s ~4%), but biologically appropriate for slower human senescence turnover.
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