Is he a telemarketing doc? Can you share his contact info if he’s accepting new patients?
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Yes, hahaha - I guess its a Deck- Pec - I can do 190 lbs 30 reps in a set. The medical students call it the chest/fly machine. Been stuck at 190 lbs for a year or two. I weigh about 190 right now. If I go up to 200 lbs with no stress - for me that would be a significant improvement.
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As you might guess, he is booked solid. He has 3 offices in the area - all rural Missouri - Unfortunately, he doesn’t do telemarketing. Younger progressive doctor. My visit yesterday, he old me his personal practice will be focusing more on weight loss and hormone therapy, but I will still get total care.
Very focused on shared research and worked with me. Has been a freind for 20 years and my physician for the last 6 years – approved me to go on TRT, Rapamycin, HGH and Empaglizozin SGLT-2 Jardiance and now Maraviroc.
He just took over my Finasteride and Tadalafil prescriptions from my Urologist who is no longer seeing patients due to his own health issues. My PSA is under 1 … at .9 didn’t really need a urologist. I just liked it – and insurance covered the extra physician.
Very lucky to have this guy.
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Amazing. Ask him about switching you to Dutasteride. Less potential side effects (google “finasteride syndrome”)
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Post-finasteride syndrome is not a real condition. Moreover, dutasteride is a more potent inhibitor of 5ar type 2 compared to finasteride and strongly inhibits 5ar type 1 while finasteride only binds very weakly and reversibly to it. On top of that, finasteride has a half life of 6 hours, totally leaves your tissue within two weeks and from all the rcts and case studies we have, side effects totally disappear within 1-3 months. Dutasteride, on the other hand, has a half life of 5 weeks and can potentially stay in your system for 6-12 months after cessation.
The only reason less mentally ill men claim they got persistent side effects from dutasteride is simply because far less men are on it than on finasteride. But there certainly are forum anecdotes for persistent dutasteride side effects.
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The translational protocol you quote is errorenous. AI made a major mistake and didn’t account for species differences in receptor affinity nor differences in delivery method. A proper translational calculation shows 37mg every two weeks is the human equivalent to the dosing the mice received.
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I am probably a bit unique on this forum as a proscar/finasteride user for 34 or 35 years. Started to keep my hair. 
It worked.
My physician and I actually discussed this as I requested he continue my urologist’s prescription and we decided to stay the course with finasteride.
Benefits: Walnut sized prostate, kept my hair… no ED issues… wake to morning wood. And, new research says it clears cholesterol from the blood.
Appreciate your heads up.
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Thanks for this… even 32 mg is 1/20th of an HIV user daily dose.
Might start higher and just see. Will review all markers in 3 - 4 months.
Definitely will keep your protocol on my back burner. Appreciate the message.
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So did your doctor make that dosing recommendation (75mg every other day) based on this thread (that you shared with him) or on his own research?
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Combo - based on his familarity with the drug from HIV infected patients on treatment. We discussed trial and if anything is an issue - immediatley get in touch with him. Was the same for starting rapamycin as an early adopter. We selected a 3-month visit plan and daily outreach if any issues arose. Nothing ever happened. But, back then it was even more experiemental - with a dosing plan 6-8 mg weekly.
He perused a few articles on Maraviroc and the one posted by RapAdmin with the translational information during our visit - we spent over an hour chatting on everything longevity as it pertains to my protocol. Pretty typical visit because he is fascinated by my progress and benefits. Calls me a medical case study in improvement and longevity. He is about 46 years old. So, maybe preparing for his future too.
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The HIV dosing is designed to provide continuous receptor occupation asymptotically approaching 100%. For aging, this sort of dosing is completely unneccessary. I had Claude Opus 4.5 estimate receptor occupancy profiles for differing dosing frequencies using a 37.5 mg dose for a 70 kg individual.
Summary Table: All Frequencies
| Dosing Frequency | Peak RO | Average RO | Minimum RO | Time <90% RO | Time <50% RO | Time <20% RO |
|---|---|---|---|---|---|---|
| Daily | 98.9% | 98.4% | 97.5% | 0% | 0% | 0% |
| Every 2 days | 98.4% | 96.0% | 92.0% | 0% | 0% | 0% |
| Every 3 days | 98.2% | 93.0% | 81.8% | 25% | 0% | 0% |
| Twice weekly | 98.1% | 91.0% | 75.0% | 35% | 0% | 0% |
| Weekly | 98.0% | 65.0% | 13.0% | 62% | 30% | 12% |
| Every 10 days | 98.0% | 45.0% | 1.2% | 73% | 50% | 33% |
| Biweekly | 98.0% | 28.0% | ~0% | 79% | 64% | 50% |
The optimal receptor occupancy for anti-aging benefits is unknown. The mouse studies achieve low occupancy. I think this is an artifact of mouse receptor binding affinity rather than by design. The key piece of information from the mouse studies is that despite low occupancy, significant benefits were seen. Analyzing the mechanisms of action seems to indicate better benefits would be achieved with continuous 50-80% occupancy, but again this is speculation. The biweekly dosing best represents the mouse study profiles. Taking everything in aggregate, I’ve decided to move to dosing 37.5 mg/weekly.
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For comparison, here’s what was used in the mouse studies:
| Regimen | Peak RO | Avg RO | Min RO | Time <90% | Time <50% | Time <20% |
|---|---|---|---|---|---|---|
| MOUSE STUDIES | ||||||
| Stroke (100 mg/kg IP qd) | 90% | 22% | <1% | 98% | 79% | 67% |
| Sarcopenia (10 mg/kg IP qd) | 48% | 8% | <1% | 100% | 100% | 88% |
| Acute neuro (20 mg/kg IP qd) | 65% | 14% | <1% | 100% | 90% | 81% |
| Frailty (~50 mg/kg oral cont.) | 50% | 22% | 7% | 100% | 78% | 45% |
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Really appreciate your deep dive here @fasterfour . Maraviroc is a totally new opportunity in muscle growth and strength… so of course still seeing what protocol is best. And, accounting for diffences by genotype and phenotype.
Should be receiving my Maraviroc today, as I mentioned, only 1 out of 3 pharmacies stock it… or have access. So my main pharmacy sent my prescription to another pharmacy to be filled. I have my baseline bicep and chest measurements. And my workout routine for past year… machines, weight amount and sets.
I am planning on a doing a loading dose of of 32 mg daily for a few weeks… much like you would do when starting Creatine. Then, see about backing it off, same dose every 3 days. Try this for 3 months and compare muscle 
growth measurements and any workout improvement in weight load and reptition number per set, to baseline.
Should have something to report by end of April or early March.
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Just returned from the medical university gym… the Director took my measurements and grip strength scores.
Here is my pre-Maraviroc dosing baseline for February 6, 2026.
I will retest in 3 months, May 6, 2026. My N=1 human trial.
What is Considered a Good Grip Strength (Average Ranges)
- Men: 97-121 lbs (20s) to 66-92 lbs (60s+).
- Women: 60-77 lbs (20s) to 40-62 lbs (60s+).
Note: Grip strength can be tested using a handheld device called a dynamometer.
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I am glad you lift regularly (so later strength measurements are not confounded by newbie lifting gains) and have some pre-Maraviroc baseline benchmarks to compare against.
Looking forward to see your progress Maraviroc!
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Yes, I think I am a good candidate to see if Maraviroc helps, as I am pretty shredded and stable in my workout routine and ability… with over one year of no improvements. I am ready to move up.
We are fortunate to have the best in longevity research… and honesty… as a frequent flyer on this excellent site - Dr. Matt Kaeberlein. I private messaged him for his thought on Maraviroc.
My message:
Matt we have been corresponding for 4 years. I have learned a lot from you and Dr. Peter Attia over the years.
I am feeling like I am decades younger. And, blood panels, physical ability and biological markers indicate I am functioning at a much younger age level than my chronological age. Thanks.
I am curious about your take on the medication Maraviroc that is reported to increase both Muscle Mass 28% and Endurance 20% Could be a great topic for Optispan.
Link: HIV Drug (Maraviroc) Reverses Muscle Aging by purging “Zombie Cell” Signals
Is this something you might try?
You are the most trusted longevity expert in the field. Truth!
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The reply from:
MKAEBERLEIN Longevity Researcher & Expert.
Thanks man!
More episodes of the podcast coming soon, I promise. It’s great to have many interesting projects at the same time, but only so many hours in a day. Re: Maraviroc, I agree that mouse study is pretty interesting.
My gut reaction is that it’s probably a real effect, although magnitude might be overstated even in mice.
We’ll see how well it replicates.
Intriguing to think it might do the same in people.
If the effect size were similar, I’d guess we’d already know since hundreds of thousands of HIV patients have taken it for many years at doses that ought to be comparable.
Could be hard to tell in that population though.
Side effect profile doesn’t seem terrible.
Given some of the far more wacky stuff people are trying out there, I’m guessing we’ll get some first hand reports here pretty quick from biohackers who see this paper and decide to go for it.
Maybe even a Bryan Johnson video.
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I guess I am the biohacker ready to try it…
Got my medication. Refills for one year. Cost $198 per refill… my cost $10.
Got my pill cutter… 1/2 of a 150 mg pill or 75 mg one day… skip a day. Or, every other day.
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Through insurance, my actual cost is $10.
My physician and I thought it would be about $100.
This is a nice surprise.
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Because you’re in better shape than most, I wonder if the effects would be as noticeable, if at all, as opposed to someone with moderate or advanced sarcopenia. (?)
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