LDN and rapamycin

Maybe this is a question for my pharmacist, but I was wondering if anyone here takes both LDN and rapamycin/sirolimus at the same time with no issues? I started 5mg of sirolimus on Friday night for severe, chronic fatigue. I accidentally forgot to take my LDN medication that same night. I’m supposed to take 5mg of the sirolimus once a week.

I felt awful with fatigue the day after (Saturday), which is better today. However, I have nerve pain in my mouth/throat that started to flare up yesterday and got really bad last night into today. I can’t think of anything that should have set it off, since I’m always careful with what I eat now. The only correlations that I can think of is either missing an LDN dose or starting the sirolimus.

My stomach was off yesterday and I was constantly burping, which I think was the sirolimus. I’m not sure if that maybe triggered acid reflux or not, which sometimes irritates my nerve pain. The pain is worse than usual though when that happens.

I guess I’m a little worried about the LDN and sirolimus canceling each other out.

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Hi, welcome to our forums.

yes, LDN has been discussed quite a bit here, and many people take both at the same time. Here are some past discussions you may want to review:

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Yes I have taken both at the same time with no issues.