Preservative for LDN solution

Firstly, I apologize in advance if this is the wrong place to ask this question but I don’t know where else to ask it.

I have just received some 50mg Naltrexone tablets which I ordered from Inhouse Pharmacy. I intend to make my own LDN from them.

I actually want to make from one pill a liquid solution which will last for at least 100 days without going off or denaturing. I have done some research into preservatives and I am thinking that pure vinegar might be the answer but I might be wrong.

Is there a risk that the vinegar could damage the Naltrexone molecules?

Can anyone suggest another way of getting a liquid solution of Naltrexone to last for more than 100 days without any damage to the Naltrexone molecules?

Thank you very much.


In the US a 90 day supply of compounded LDN capsules, 4.5mg dosing per day cost $100.00 delivered to your door including the prescription.

Why would you want to “make” your own?

Using tablets?

You are aware tablets contain other compounds besides the API.

Suggest/recommend you review information at the “LDN Research Trust”

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Thank you, Joseph and scta123 very much for your answers.

I am actually wanting to make a liquid Naltrexone solution which will last more than 100 days at room temperature no matter how often I open and close the container.

It seems that nobody here knows what effect vinegar will have on Naltrexone molecules. I have searched on the Internet but I can’t find the answer.

Does anyone here know of a place on the Internet I may not have looked?

Does anyone here know of an expert who I can contact who might know the answer?

I have seen a paper that uses orange juice, which is acidic, so vinegar might be ok. I personally might use ascorbic acid or citric acid… I can’t imagine vinegar solution would taste good.
But since paper said the solution is stable at room temperature for 30 days, why would you really want to do something that would last you 100+days as the whole process takes like 5 minutes of crumbling pills and adding water and mixing the two?

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Thank you scta123 for your informative reply and sorry for the delay in getting back to you. I have been very busy.

The reason I am wanting it to last more than 100 days is that I am wanting to take a very low daily dose of 0.5mg of Naltrexone. This means that a 50mg tablet contains 100 doses of the dose I want to take.

I have found a paper on the Internet called “Inexpensive Compounding of Low-Dose Naltrexone With Orange Juice”. Is this the paper you have seen or is it a different one?

Thank you very much.

Yes, I think it is the one.

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I have done a lot more research and I think I have found the answer.

I have found a research paper which says that the Naltrexone in the formulation that the researchers used did not undergo any decomposition whatsoever after 90 days at 25°C. The formulation they used was basically cough mixture. The ingredients of their formulation were as follows:

Ascorbic acid (0.5%),
Sodium benzoate (0.1%)
Glycerol (20%)
Distilled deionized water (to 100%).

I have therefore decided that I will use cough mixture as my Naltrexone base. I will look for cough mixture which contains sodium benzoate.

According to the following link, cough mixture can last up to two years even if opened. (Look at the post by Donna Caulfield.)

This suggests that the BBE dates on cough mixture bottles are far too cautious.

The title of the research paper is “Formulation and Stability of Naltrexone Oral Liquid for Rapid Withdrawal from Methadone”.

Even though the abstract etc are free to read, I had to pay £32 for the full paper, without which I would not have been able to obtain the ingredients of their formulation.

I will now need to work out a way to thoroughly and evenly mix the Naltrexone throughout the cough mixture which I expect will be somewhat viscous.

While sodium benzoate is considered safe, scientists have shown that negative side effects occur when it’s mixed with ascorbic acid (vitamin C) . Their studies indicate that it then turns into benzene, a known carcinogen that may cause cancer

It happens both with citric and ascorbic acid with sodium benzoate. Even Coca Cola is formulated differently since 15 years.

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Thank you scta123 very much for your warning about sodium benzoate.

I think I have found some more reassuring information here:

(See Giles Henley’s post)

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