mTOR inhibitor for Skin Health and Rejuvenation
This is a continuation of this thread: How to Reverse Skin Aging (2025)
It seems like the evidence for significant benefits of topical rapamycin (i.e. rapamycin skin cream) gets stronger and stronger every year. There are now two companies that are developing topical skin creams using mTOR inhibitors for skin aging:
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RapaLogix: A New Rapalog for Skin Aging: Rapalogix Health RLX-201
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Hayflick Partners (Matt Kaeberlein is on the advisory board): https://www.hayflickpartners.com , and they mentioned in the recent podcast that this company was developing a topical version of rapamycin.
and many here have been using topical rapamycin for a long time using this protocol: DIY Rapamycin skin cream
Omipalisib
I also realized when listening to this recent podcast interview with Ben Blue of Ora Biomedical that they’ve had great results with the mTOR inhibitor Omipalisib (GSK2126458), and have now standardized using it as a positive control in all their experiments because it much better than rapamycin.
It seems like it would be quite easy and low risk to swap out the rapamycin in the DIY Topical skin cream, for the Omipalisib (GSK2126458), assuming you can actually get your hands on Omipalisib (its available from many lab supply companies, but that doesn’t mean its easy to get). In earlier rapamycin skin cream research it was shown that the rapamycin does not enter the blood stream when applied topically (so systemic risks are minimal).
Anyway - this is something I think I will try to look into this coming year, and try it out if I can get it sourced.