I’ve read with interest the long discussions about topical Rapamycin cream but could not find much about protocols/dosage.
I got the 0.2% topical rapamycin cream from Heathspan (gethealthspan.com). That’s a molar concentration of 2190µM/liter which is much more than what has been used in the literature.
For instance in that paper: Stimulation of Hair Growth by Small Molecules that Activate Autophagy
Rapamycin (1.6 µM) induces hair regeneration
[…]Rapamycin at 100 nM gave similar results as 1.6 mM
[…]Rapamycin at 16 µM, however, resulted in hair loss and open wounds
Obviously that’s much lower than 2190µM in fact 1.6µM is (0.00015%). That’s on mice though.
They use a 0.5ml on each hand of a rapamycin cream with a concentration of 10µM (0.001%) every 24-48 hours. This is also very much lower than the Healthspan cream.
The 0.1% to 0.2% concentration is used for the treatment of skin problems like Angiofibromas among others but it’s not the goal here.
Currently I use it once a week but I think it might still be too much.
Any feedback on that? What protocols/dosage are you using if you use it?
BTW I currently also take 5mg pills once a week.