Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity

#1

A good overview of the approach longevity clinics are taking. Most of us here have worked are way up the pyramid and are at, or near, the top, I suspect.

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Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive review introduces the innovative concept of the “Longevity Pyramid .” This conceptual framework delineates progressive intervention levels, providing a structured approach to understanding the diverse strategies available in longevity medicine. At the base of the Longevity Pyramid lies the level of prevention, emphasizing early detection strategies and advanced diagnostics or timely identification of potential health issues. Moving upwards, the next step involves lifestyle modifications, health-promoting behaviors, and proactive measures to delay the onset of age-related conditions. The Longevity Pyramid further explores the vast range of personalized interventions, highlighting the importance of tailoring medical approaches based on genetic predispositions, lifestyle factors, and unique health profiles, thereby optimizing interventions for maximal efficacy. These interventions aim to extend lifespan and reduce the impact and severity of age-related conditions, ensuring that additional years are characterized by vitality and wellbeing. By outlining these progressive levels of intervention, this review offers valuable insights into the evolving field of longevity medicine. This structured framework guides researchers and practitioners toward a nuanced strategic approach to advancing the science and practice of healthy aging.

Open access paper:

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#2

Thank you for sharing this helpful organised set of resources. Good to have a structured overview. Will follow links and resources.

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#3

I’m struggling a bit with whether the bottom two sections of the pyramid should be reversed?

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#4

I rationalized the sequence by thinking that most people are sick in some way: a1c / insulin resistance, BP, heart disease, kidney function, etc. the first thing to do is to figure out what is going to kill them first. Get drugs to dramatically slow the accelerated aging. Then get the life in order; maybe get off drugs someday.

I say to always go for low hanging fruit. Quick wins provide motivation. It’s hard when the only things in life that provide pleasure have to go. It’s not a good life but it’s all they have.

#5

They didn’t mention peptides?

Also the supposedly atherogenic 2py/4py thing comes from NAD, not directly niacin. But you hear people getting good things from even the IV NAD. So this one is not (for me) very solid. It has a ways to go.

#6

That certainly makes sense from the standpoint of extending the average lifespan of the population. I don’t know that it’s best for extending health span?

#7

In my mind, they should be reversed from pragmatic perspective. Not all have access to comprehensive diagnostics but all can attempt lifestyle changes.

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