Just got my 3 month blood results after taking 3mg Rapa once a week.
LDL went up from 4.0 to 4.1 mmol/l
Triglycerides up from 0.6 to 0.8 mmol/l
Fasting glucose came down from 5.7 to 5.2 mmol/l
Insulin went up from 3 to 4
A1c down from 5.3 to 5.2
Scores from Phenoage calculator:
Mort score increased from 0.048 to 0.062
Ptypic age increased from 50.36 to 53.28
est DNAm age increased from 49.38 to 52.49
Est D Mscore increased from 0.045 to 0.057
Overall I’m not that impressed with the results. It would appear that while there were not exactly drastic negative changes, they didn’t give me much faith that Rapamycin is an especially helpful longevity intervention for me.
Aside from the blood test results have you noticed anything positive or negative in terms of side effects or benefits / changes in physiological function?
Your albumin is at the low end. Is the CRP number correct? I calculated that 0.1 Ln(mg/dL) is about 11mg/L. Anything above 10mg/L is considered high and a sign of inflammation.
@Basil_Dev Thank you for being so generous to share this information and your blood test results, Basil. This is the type of information we can all learn from. I can imagine this blood test result is not what you were hoping for - I’m sorry to read this. Sorry for asking, since I realise you would have likely mentioned if this was the case; but there were no other apparent changes in your lifestyle in the past period?
@RapAdmin RapAdmin, are there more members that have posted elaborate pre- and post rapa blood work the past period?
You shouldn’t be impressed, those are not great results. I’m puzzled by them, to be honest. While we’ve seen some people with fairly flat results, I suspect that that is for people who are already pretty well optimized (in terms of diet and physical fitness) and perhaps rapamycin in the short term doesn’t add that much at the doses we are using.
How is your general fitness level - do you exercise on a regular basis and have you continued doing so at the same rate during the three months you have been on rapamycin? Any other conditions or factors that might have impacted the outcomes?
If you take a break from rapamycin I wonder if it might bounce back better than before - please report back in either case. Perhaps wait 2 months and do another blood test and check…
this is what happens to the mice and rats too, yet in spite of these bad results or maybe because of them rapamycin extends their life besides these lab changes are so small that they are just normal fluctuations with the margin of error, not statistically significant
We don’t really know, do we… But we do have some interesting positive data from the transplant patients, the influenza vaccination trial and lots of positive data on the positive effects on t-cell populations in humans
