Women Taking Rapamycin for Enhanced Fertility / Menopause Prevention?

Hi - I am interested in starting Rapamycin for extending fertility. The above linked articles were very interesting. Do you know what protocol dosage and duration would be recommended? Or a good place to start? Thanks! :slightly_smiling_face:

1 Like

So - a human clinical study is just being started on this at Columbia University focused on this use. I will be talking with a woman who is somewhat involved with this study in the next week and I’ll post details on what they are doing.

Right now there is no evidence-based protocol because this is all very new. Fundamentally what I’m seeing is people are following the general anti-aging protocol / dosing for rapamycin as outlined here: What is the Rapamycin Dosing / Dosage for Anti-Aging or Longevity, and Life Extension?

Some women are posting on twitter about their rapamycin use:

2 Likes

And read this post: The Case for Rapamycin, and Female Fertility

1 Like

Great, thanks that will be very interesting to hear about the human clinical trial. Also good to know about people mostly doing the longevity dozing for extending fertility. I was curious about that because of the cited mice trials where follicle growth/ovarian function was impaired during the Rapa dosage of 2 weeks and then for 2 months following, but after that the follicular growth and ovarian reserve were better than ever. So curious how that translates to humans. Like if ovarian function is impaired during the Rapa dosage, and how long it takes to come back for someone still interested in fertility, not just delaying menopause.

1 Like

Well, rapamyin (sirolimus) has been in use by women for over 20 years, in transplant patients - and of course, many of those women have had children. They even seem to keep these patients on the drug during pregnancy (which I found somewhat surprising), but I suspect they lower the dose as much as possible.

Generally the recommendation seems to be at least 6 weeks gap between taking sirolimus and getting pregnant, from the following paper:

Sirolimus and mycophenolate mofetil should be stopped 6 weeks prior to conception. The optimal time to conception continues to remain an area of contention.

But organ transplant patients are different than healthy people - they have to take sirolimus (or drugs like it) as part of their treatment program to keep a transplanted organ in their body functioning without problems. So - they are much more about balancing the risks of loss of a key organ, vs. potential damage to the fetus. Healthy people will want to focus more purely on minimizing risk to the fetus, so more time is probably a very good thing. Talking with an OBGYN would be a good thing for this type of thing.

As to how quickly full fertility returns… I’m not sure of the specifics. Rapamycin has some significant similarities to calorie restriction. Rapamycin in part seems to trick your body into thinking that it is nutrient deprived. Just as if a woman is eating a very low calorie diet - they will lose their menstruation cycle and ability to become pregnant until they begin eating more. The same applies to rapamycin. I have not done research on the exact speed of return to full return to fertility - you can look for research on “caloric restriction and return to ovulation” or some such terms I suspect.

1 Like

From one woman using rapamycin. 4mg/week seems like a reasonable and conservative dose for a woman age 30. I would just note that while she comments on the fact that in the mouse studies, the female mice were much more dose-responsive to rapamycin (for a given dose, much higher levels of circulating rapamycin), I don’t believe this has been found to be true in humans (i.e. women). There is also great individual variability in terms of dose responses of rapamycin - so best to do a blood /sirolimus test: How to get a Rapamycin (sirolimus) Blood Level Test

1 Like

Very interesting, thanks. Good to think about it that way - in terms of being similar to the affects of caloric restriction.

Makes sense about getting the blood test to get better insight. Is Rapamycin dosage often based on age then? Does body weight play a part?

When talking about dosing and rapamycin there are two areas to consider. Historically its been dosed for organ transplant patients and cancer patients. In those application the dosing is focused on getting the blood/sirolimus levels to a specific therapeutic range (I seem to recall something like 5 to 15 ng/mL). I’m not sure if body weight has much to do with how sirolimus dosing translates to blood levels.

Of course we are talking about rapamycin (sirolimus) for anti-aging, and we have much less data here. We really don’t know what the optimal dosing is yet. So there are no hard and fast rules.

That said, I have seen people of very low weight (e.g. 100lbs to 125lbs, 45 to 55kg), sometimes getting more side effects at a specific dose, so probably better to be cautious rather than aggressive when testing the typical dosing ranges (e.g. 3 to 10mg/week) that are common in anti-aging applications. Details see: What is the Rapamycin Dosing / Dosage for Anti-Aging or Longevity, and Life Extension?

2 Likes

Related to this general topic:

and

Related Reading:

Webinar Series:
https://www.buckinstitute.org/events/webinars/

Other News:

Whitepaper: The Unspoken Truth - Reproductive Longevity and Equality Affects Us All

My wife, with early menopause, tried with 3mg every day for 10 days for 2 months in a row. The first round she got a wicked tongue ulcer. 20 days later she did the protocol again and got swollen glands in her armpits - that stayed painful and swollen even after stopping. She also had a very light but discernable period, each month at the 30 day mark. She has stopped given how uncomfortable and swollen the underarms were…

1 Like

Wow - thats an extremely high dose level. I would expect significant side effects at that level.

I’ve found the most side-effect free approach is to start slowly, and still dose only once per week. I started at 1mg/once per week, then slowly increased by 1mg/week up to the 5mg/6mg per week. Only had one mouth sore once. I think slower, lower dosing is the best strategy, though some people have jumped right to higher dosing without problems.

Details on dosing here: What is the Rapamycin Dosing / Dosage for Anti-Aging or Longevity, and Life Extension?

3 Likes

She had been on 3mg weekly for a year. The dosing was based on an anecdotal report that had worked for another woman with a similar case. Also, it should be noted, that the menses did return - at least for now - though it’s very light. I’m certainly not reporting here as a recommendation but for information to the community.

2 Likes

Interesting - I’d not heard of that.

Do you have any more information on that anecdotal report? How long she took rapamycin, what the dosing was, for how long, and what the results were? Is there anything ever posted on any public forums or twitter, etc. that you can refer us to? The more datapoints we all can have here, the better we are all informed. Thanks in advance for any additional information you can share.

1 Like

As @RapAdmin stated, this is a massive dose outside of a cancer/transplant clinical setting. Although at 10 days, and barely 5 half lives, and without a loading dose, the full tissue effects hadn’t fully reached steady state. The side effects at a longer duration would probably amplify. The 2nd round definitely had stronger effects. At 20 days later post 1st round, most all of the Rapamycin would have been excreted and not measurable in blood, but perhaps some lingered in some fatty/high lipophilic tissue levels such as lymphocytes, ergo the swollen armpits side effects with re-dosing.

What data point someone would have to follow this protocol would be interesting to understand if some science based therapeutic rationale we’ve not seen before.

2 Likes

Oncologists usually use body surface area for dosing chemotherapy, my gf uses the one below for dosing …

(Even for obese with water soluble chemo this apparently works well)

2 Likes

Ah okay thanks that is good to know about lower weight people potentially having more side affects at a specific dose. I am 5’4" and about 125 pounds, and while that is about my ideal weight perhaps that is lower on the general scale. I will see how it goes in terms of dosage and any ramping up.

1 Like

Interesting, okay thanks

Appreciate the link. Reviewing now.

Peter Attia has a very positive opinion on how rapamycin seems likely to help women reduce age-related fertility and ovarian functional decline. See this video below, queued up at the point where he discusses it:

2 Likes