Thank you for your post.
Actually I’m taking Rapa for fertility. Knowing that about your cycles is definitely giving me more hope.
My cycles are still regularly 27 days. But flow is short, only 3-4 days. I’m hoping to be able to conceive my rainbow baby.
That’s what I was planning on doing.
I only plan to take Rapa during the first half of my cycle as well.
I’m here for the same reason. I’ve been doing my own research. That’s actually why I am only planning on taking Rapa during my early follicular phase of my cycles. Though I have only started this month.
Hopefully with this help I will get the boost that I have needed to get my rainbow baby. 
I’m also interested. What did you find? What Dr. did you use for a prescription? Any other tips? I’m 45, wanting to delay menopause, etc. Currently taking nmn, tmg, apigenin, fisetin, calcium akg, a few others.
I don’t have a doctor’s script. I’m just trying to figure it out as I go. I took 2mg for CD 1-3 this cycle. I also just added Fisetin.
Hi everyone,
Noob here. Apologies if this is a wrong question for this forum. Found this while searching for solutions for our fertility journey.
My partner (40 years old) has diminished ovarian reserve. We have struggled with no luck with IVF for 5+ years now trying various protocols. Her doctor recently suggested potentially looking into rapamycin given that nothing has really worked for us. Anyone tried it here? protocols that helped?
We understand one can’t be on rapa while pregnant, but we also understand that in small scale trials it has shown to improve embryo quality.
We dont want to be in the Columbia study as we will be older by the time the results come out. We want to experiment with rapa now.
I’m using Rapa for that purpose. I’m basically just researching and experimenting until I get something that works.
This cycle I took 2mg of Rapa daily on the first 3 days of my cycle. Took metformin daily until ovulation. Also added NMN, Fisetin, and Quercetin this cycle.
Waiting to see what happens.
Figuring it out as I go.
Good luck to both of us
Thanks for your response. Very helpful
Assume you are just using rapa pre IVF.
How long before getting pregnant will you stop rapa? Any concerns with counter actions with other drugs? Eg with Estrogen priming?
All the best to you! 
We’re using Rapa and Met during the first week of my cycle. Bromelian during the second week. Fisetin, NMN, and Quercetin daily. Not really trying to go through IVF. It’s difficult to get in my area. Nor covered through insurance. Just experimenting and seeing what happens. Hoping for the best. 
New articles on this topic:
From The Wall Street Journal:
Imagine if women never reached menopause, that dreaded middle-age milestone—or could delay it, or decide when to have it.
Women could remain fertile longer and would have more choice about when to start a family. They wouldn’t struggle with symptoms like hot flashes, mood swings and brain fog in the prime of their careers and family lives.
Even more significantly, women might live longer and healthier lives. Though menopause—a full year without a menstrual cycle—is associated with the end of fertility, it also marks another profound but less recognized change. When the ovaries stop functioning and releasing important hormones, biological aging in women speeds up, increasing the risk of numerous health problems.
…
Women who reached menopause after age 55 lived two years longer on average than those who reached it before age 40. A 2016 meta-analysis in JAMA Cardiology found that early-onset menopause in women under 45 was associated with an increased risk of heart disease and mortality. A 2021 study in the journal BMC Cardiovascular Disorders found that women who experienced menopause before age 50 had a higher risk of stroke and death. And last year, a meta-analysis that reviewed 22 studies concluded that later menopause was associated with a lower risk of dementia.
Read the full article: https://archive.ph/HdQP8#selection-243.0-265.50
Some very good news…
Rapamycin could decrease markers of enhanced oxidative capacity, 8-OHDG and MDA, and increase antioxidant markers, SOD and GSH-PX. The expression of senescence-related markers p16 and p21 in follicular fluid was significantly lower in the treatment group than in the non-treatment group.
The days of ovarian stimulation were much shorter in the treatment group compared to the non-treatment group, and the number of oocytes obtained and mature oocytes also increased considerably in the treatment group.
Furthermore, Rates of fertilization, implantation and pregnancy were significantly higher in the treatment group, whereas rate of early miscarriage were significantly higher in the non-treatment group.
80 endometriosis women who received rapamycin in the second cycle had significantly better IVF outcomes than their first IVF cycle which did not receive rapamycin. Live birth rate was significantly higher in the treatment group than in the non-treatment group. No structural abnormalities seen in fetuses born to women treated with rapamycin.
Source Paper:
https://www.sciencedirect.com/science/article/abs/pii/S1472648323004194
Has there been any research on adding Taurine to Rapa for infertility? It seems logical that it would be helpful. As it’s highest in babies and children. Plus is a large portion of breast milk. As it also goes down with age.
It helps my melatonin work much better. I’ve been sleeping better since I started it.
Are there any more articles available about it. There’s no dosage/protocol used information I can find. I’ve taken Rapa for the first 3 days of my cycle (6-8g total) for several months now. It would be nice to find more information to work with.
I’ve emailed the authors to see if I can get the dosing info, and a full copy of the paper. Will let you know if I hear anything back from them.
This study I just cited was the first human study I’ve seen regarding fertility and rapamycin that has been completed. The Columbia University trial of rapamycin for fertility is just starting so will be a few years before we know anything from that study. I think most women are just using longevity dosing of rapamycin as their guideline right now: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?
A 45 year old woman is documenting her rapamycin journey via short videos posted on twitter. If you are interested, you may want to follow her.
See this link for the video:
https://x.com/DavisonVideo/status/1704540290566996350?s=20
‘Undeniably groundbreaking’ work shows that declining egg quality in older mice can be reversed with a dietary supplement.
Declining fertility in older mice has been reversed by giving the animals a compound already found in most living cells. The process also causes them to produce larger litters. The findings, published today in Nature Aging 1, offer clues that could aid the development of treatments for humans with fertility issues.
The chances of falling pregnant — naturally or with assistive technology such as in vitrofertilization (IVF) — become slimmer with age. This can be traced to reproductive cells in the ovaries called oocytes, which deteriorate and decrease in number throughout life.
A molecule called spermidine — first isolated from sperm but now known to have functions in many types of cell — has been shown to lengthen lifespan in yeast, flies, worms and human immune cells. Increased dietary intake of spermidine has also been linked with reduction of age-related problems in laboratory animals, including cardiovascular disease in mice and cognitive decline in fruit flies. But its effects on ageing oocytes were unclear.
https://www.nature.com/articles/d41586-023-03224-x
https://www.nature.com/articles/s43587-023-00498-8
Related News Coverage:
Related threads:
Here: Spermidine delays aging in humans
Here: Generally recognized as safe (GRAS) assessment of a spermidine rich wheat germ extract
Have you seen this study, a similar effect with AKG
