Just purely symptomatic. Increase in coughing, congestion in the lungs, shortness of breath and the like. Rapamycin at high doses can induce interstitial lung disease (ILD), but I’m speculating that there may be individuals who respond this way at what most of us would consider “lower” doses, just a danger to be aware of. Being sensitized to this side effect means you won’t ignore symptoms - fortunately ILD resolves upon rapamycin discontinuation. A formal diagnosis is through lung imaging tests.
We have mTOR for reasons and turning it low will have effects.
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As if it weren’t already complicated. Taking rapamycin with GFJ significantly alters the uptake and clearance profile over taking it with a fatty meal or taking a high dose. I’m not certain whether this alteration is beneficial, harmful, or neutral. Also, I think we have established that assimilation varies significantly across brands based on whether and how the raw Chinese product is processed.
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I don’t think it affects the half life just the bioavailability. I accept predicting the effect is hard. Hence i started with GFJ at a low dose and built up.
interesting-3 wks. at what dose may i ask? I went to 2 weeks because I went to a higher dose to try to get past the “blood barrier” I’ve read about…
I checked out goodlabs. the less expensive lab is too far from me to make it worthwhile but there is a Labcorp in the next town. A sirolimus test is like $17 (plus a $12 blood draw fee I think) but that seems reasonable. What are some of the other recommended markers to check? I can get most of the normal ones from my PCM (A1C, chol, testosterone, etc) and their lab but the ‘weird’ ones people check because of sirolimus use; I can’t get with my PCM.
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I suggest you check out these blood tests - the Levine phenotypic calculations require the same regular blood tests I like to get at a minimum: Blood Tests and pricing for Levine Phenotypic Calculation , and Bortz Biological Age Calculation
Some other good blood test threads:
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Sudiki, fyi, incase a quest is closer to you, goodlabs also offers them as an option and they are usually less expensive for most things, goodlabs even points that out. There is a dropdown menu to choose quest if you didn’t notice it.
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thx but quest was the one that is too far from me to be useful. and the cost is 17 for sirolimus at quest, 16 at labcorp. also quest wants 12 for blood draw, labcorp is 8
FYI, Goodlabs provides a “free” Bortz Biological age calculator, based on uploaded labs.
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Not wanting to deter too far… but I strongly feel the underpowered Stanfield Study only muddied the waters and God love him… and as we say in Missouri bless his heart (not a compliment), but his monetary sacrifice was IMHO a waste of his and wife’s money. They tried… it required a lot more.
Granted, nobody expected a wealthy reputable pharmacist, Ken Coit to ante up $12 million dollars for a single rapamycin human trial with our respected Matt Kaeberlein advising the study. But, he has… and real, undeniable and thorough results will finally be available. Albeit, you must wait 6 years.
As Blagosklonny quoted… “If you wait until you are ready, it’s almost certainly too late.” Seth Godin
I know my early adoption of rapamycin, now 5+ years ago is paying out in Aces… at 6 mg per week.
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Hey @Agetron,
Post Stanfield study, the conversations here led me to switching from 8mg weekly to 16mg every other week, so I ask….
Do you know if Kaeberlein still feels weekly is optimal, or is he now perhaps on the fence regarding frequency. I realize he takes very long breaks, so his protocol might not be relevant to me… my older self hates even skipping a dose post vaccine!
PS, I do not have enough muscle, so I’m in the gaining and not maintaining phase.
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Are you taking Pfizer Rapamune? Thanks.
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I’m taking the generic I get from CVS.
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Maybe the drug has issues about absorption.
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Ah, @man_li, I think you were asking because my dose is so high. Yeah, it seems weird, especially because I’m pretty small.
I think it’s more about me than the quality of the generic. I say this only because there are many people who source it at CVS and we don’t see reports about their labs showing them anything surprising. I guess there could be batch differences ?
My labs showed 6mg was too low for me and 8mg is in the sweet spot. I buy a years worth at a time, so perhaps I’ll test again next time I get a new supply.
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The issue with biological availability that was identified a few years ago was in the “Compounded Pharmacy” version of sirolimus. This is when the pharmacy makes the drug / pills in the pharmacy using purchased powders, and puts them into a capsule. The issue was that the capsule was not protecting the sirolimus as well as the formally manufactured (by pharmaceutical companies) sirolimus in regular pills. The generic sirolimus in the USA is all manufactured as pills by pharma (mostly in India) and do not have the asborption problem that the compounded pharmacy capsules do / did.
For more info, see this thread: Bioavailability of Rapamycin From Compounding Pharmacy
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do you take it with anything? i read some take with fatty food like sardines in oil or with olive oil etc.
I take it with sardines or olive oil. The fat increases bioavailability by about 30%.
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Hello Beth…
He had been taking 8 mg weekly with breaks every few months… he did mention he is a fast absorber… and it clears fast too.
I really think doses can be very individualized. Your physical stature… small skinny , avrrage fat, lean muscled and genetics.
I’ve been as high as 12 mg weekly… was too much… and as low as 4 mg weekly… too low. I started at 6 mg… good results and returned to that dose… 6 mg weekly.
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