Higher doses of rapamycin have been an area of discussion and interest here. Its unknown whether these higher doses are helpful or harmful in terms of human longevity and healthspan, but I think its good that people like MD David Barzilai is tracking and working with people doing this type of thing under close supervision, and reporting on the results.
As I remember the video, the client developed some sort of response (I think it was heart palpitations) that prompted an ER visit. This high a dose is definitely not recommended.
Note: Video below has been disabled by Dr. David Barzilai. Following is what ChatGPT5 has gathered on the past report:
Here’s everything that’s publicly findable about the “Ultra-high Dose Rapamycin (500–1000 mg)” case—and what we can (and can’t) conclude from it:
What the case is
- The item originates from Agingdoc (Dr. David Barzilai) discussing an N=1 who reportedly self-administered ultra-high single-course oral rapamycin totaling 500–1000 mg. The reference most often cited is his Podcast Episode 8, Part 4 (“Ultra-high Dose Rapamycin Case Report 500–1000 mg Rapamune”), published Jan 13, 2024. The episode exists on major platforms (audio description available), but a detailed written case report is not posted.
- A community summary post titled “Ultra-high Dose Rapamycin Case Report 500–1000 mg” on Rapamycin.news links to the podcast/video but does not reproduce dosing tables, labs, or a transcript. It frames the content as documentation by Barzilai and points to related threads on high-dose experimentation.
Corroborating crumbs from the same circle (lower doses)
- In earlier public tweets (embedded and quoted on Rapamycin.news), Agingdoc mentioned an N1 who took 104 mg over 6 hours and later 144 mg over 36 hours, warning that such doses are “playing with fire.” This is far below 500–1000 mg, but shows the context of escalating single-course doses discussed by the same source.
Outcomes disclosed publicly
- For the 500–1000 mg episode specifically, no open, text-based source provides concrete outcomes (vital signs, trough levels, AUC, adverse events, lab panels) beyond the podcast title/description. The Rapamycin.news link and show-notes page do not include clinical data. Bottom line: details are not publicly documented in writing; they’re gated inside the audio/video.
How this compares to published overdose literature (for scale)
- Multicenter overdose series (Europe, 2002–2013): five acute sirolimus overdoses, max 103 mg in an 18-year-old; outcomes were non-life-threatening (mild cholesterolemia; a child with fever/GI upset after 3 mg). This sets a peer-reviewed reference point that triple-digit mg exposures have occurred without catastrophic toxicity, but the doses are an order of magnitude lower than 500–1000 mg.
- Community recap also notes the 103 mg suicide attempt case (again, mild issues only).
Safety signals from adjacent literature (not the 500–1000 mg case)
- Serious adverse events, including sepsis and death, have been reported with high-dose/continuous everolimus(rapalog) in oncology/TSC settings—relevant because risk rises with dose + duration (immunosuppression). That’s different pharmacokinetically from a one-off bolus but underscores hazard at high exposures.
Takeaways
- Existence: There is a widely referenced Agingdoc audio/video segment about an N=1, 500–1000 mg rapamycin exposure.
- Public details: Outside the audio/video, no hard data (exact timing, formulation, measured blood levels, adverse-event log, follow-up) are published. Treat the claim as anecdotal pending a written case report.
- Context: Published medical literature documents overdoses up to ~103 mg with limited acute toxicity, but nothing peer-reviewed approaches 500–1000 mg in a single course. Extrapolating safety from 100 mg to 1000 mg is not valid.
Related Reading:
Here: One User Trying Very High Doses of Rapamycin, and Negative Adverse Events / Results
Here: People pushing the upper limits of Rapamycin Doses - Any One Else?
Here: Ideas on Protocols for Testing Higher Rapamycin Doses
Here: 20 Mg of Rapamycin every other week
Here: More Rapamycin Might Not Be Better
Here: Intramuscular (IM) + Intranasal (IN) Rapamycin - A new paradigm for human longevity translation
